Abstract
Objective
To test the expression of mutant p73, p53, ER and PR proteins in the esophageal normal mucosa, hyperplasia, dysplasia and squamous cell carcinoma, and research the clinically pathological significance and the correlation, for the early diagnosis, prognostic measure and therapy in clinic.
Methods
With Immunohistochemistry, it was examined to show these tumor markers’ expression in different epithelial lesions of 40 esophageal squamous cell carcinomas, 14 dysplasias, 14 hyperplasias and 14 normal mucosas.
Results
The expression of p73 was 55%, 21%, 0% and 0% in the esophageal carcinoma, dysplasia, hyperplasia and normal mucosa, respectively. The significant difference in expression of p73 (P<0.001) was observed between the esophageal normal mucosia, hyperplasia, dysplasia and esophageal squamous cell carcinoma with Fisher’s exact test. Difference in expression of p73 (P<0.05) was observed between the esophageal squamous cell carcinoma and dysplasia with χ2 test. The expression of p73 showed non-correlation with the patient’s age, sex, tumor’s grade, lymph-node metastasis and invasive depth (P>0.05); Similarly, the expression of mutant p53 was 67.5%, 35.7%, 7% and 0%, respectively; In like manner, the expression of ER was 55%, 21.4%, 14.2% and 0%, respectively; The expression of PR was 57.5%, 14.28%, 0% and 0%, respectively. The significant difference in expression of PR (P<0.001) was observed with Fisher’s exact test. Difference in expression of PR (P<0.05) was observed between the esophageal squamous cell carcinoma and dysplasia with χ2 test. The expression of PR (P<0.05) was correlated with lymph-node metastasis, and showed non-correlation with the patient’s age, sex, tumor’s grade, and invasive depth (P>0.05). Moreover, over-expression of mutant p53 and p73 showed significant correlation with ER and PR protein’s positive expression (P<0.05).
Conclusion
P73 protein may become a new tumor’s marker to diagnose esophageal squamous cell carcinoma. Because the expression of p73 protein was closely correlated with ER and PR, they could be simultaneously examined to help to early diagnose, prognosticate and cure esophageal carcinoma.
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Fan, S., Ai, J., Wang, J. et al. Expression of p73, ER and PR in esophageal carcinoma and precancerous lesions. Chinese German J Clin Oncol 5, 427–430 (2006). https://doi.org/10.1007/s10330-006-0518-6
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DOI: https://doi.org/10.1007/s10330-006-0518-6