Abstract
Many diseases such as cancer are cured by natural substances, yet practical applications are limited by low pharmacodynamics due to poor solubility and permeability, photosensitivity, chemical instability, and first-pass metabolism. These issues are partly solved by nanotechnology. Here, we review briefly lipid-based nanomaterials for drug delivery. Indeed, lipid nanoconstructs allow active and passive targeting, biocompatibility, improved safety, and efficacy. Lipid nanoconstructs include both vesicular- and particulate-based systems such as liposomes, lipid micelles, solid lipid nanoparticles, and nanostructured lipid carriers.
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References
Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K (2013) Liposome: classification, preparation, and applications. Nanoscale Res Lett 8(1):102. https://doi.org/10.1186/1556-276x-8-102
Arora D, Jaglan S (2018) Therapeutic applications of resveratrol nanoformulations. Environ Chem Lett 16:35–41. https://doi.org/10.1007/s10311-017-0660-0
Badawi NM, Teaima MH, El-Say KM, Attia DA, El-Nabarawi MA, Elmazar MM (2018) Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study. Int J Nanomed 13:1313. https://doi.org/10.2147/ijn.s154033
Baek J-S, Na Y-G, Cho C-W (2018) Sustained cytotoxicity of wogonin on breast cancer cells by encapsulation in solid lipid nanoparticles. Nanomaterials 8(3):159. https://doi.org/10.3390/nano8030159
Bai C, Zheng J, Zhao L, Chen L, Xiong H, McClements DJ (2018) Development of oral delivery systems with enhanced antioxidant and anticancer activity: coix seed oil and β-carotene coloaded liposomes. J Agri Food Chem 67(1):406–414. https://doi.org/10.1021/acs.jafc.8b04879
Banerjee S, Pillai J (2016) Lipid nanoparticle formulations for enhanced anti-tuberculosis therapy. Nanoarchitectonics for smart delivery and drug targeting. Elsevier, Amsterdam, pp 285–313. https://doi.org/10.1016/B978-0-323-47347-7.00011-2
Banerjee S, Pillai J (2019) Solid lipid matrix mediated nanoarchitectonics for improved oral bioavailability of drugs. Expert Opin Drug Metab Toxicol 15(6):499–515. https://doi.org/10.1080/17425255.2019.1621289
Banerjee S, Roy S (2019) Polysaccharide installed lipid nanoparticles in targeted antituberculosis drug delivery applications. In: Polysaccharide carriers for drug delivery. Woodhead Publishing, pp 397–411. https://doi.org/10.1016/B978-0-08-102553-6.00014-3
Banerjee S, Roy S, Nath Bhaumik K, Kshetrapal P, Pillai J (2018) Comparative study of oral lipid nanoparticle formulations (LNFs) for chemical stabilization of antitubercular drugs: physicochemical and cellular evaluation. Artif Cells Nanomed Biotechnol 46(sup1):540–558. https://doi.org/10.1080/21691401.2018.1431648
Bhatt H, Rompicharla SV, Komanduri N, Aashma S, Paradkar S, Ghosh B, Biswas S (2018) Development of curcumin-loaded solid lipid nanoparticles utilizing glyceryl monostearate as single lipid using QbD approach: characterization and evaluation of anticancer activity against human breast cancer cell line. Curr Drug Deliv 15(9):1271–1283. https://doi.org/10.2174/1567201815666180503120113
Bondì ML, Emma MR, Botto C, Augello G, Azzolina A, Di Gaudio F, Craparo EF, Cavallaro G, Bachvarov D, Cervello M (2017) Biocompatible lipid nanoparticles as carriers to improve curcumin efficacy in ovarian cancer treatment. J Agric Food Chem 65(7):1342–1352. https://doi.org/10.1021/acs.jafc.6b04409
Buenz EJ, Verpoorte R, Bauer BA (2018) The ethnopharmacologic contribution to bioprospecting natural products. Annu Rev Pharmacol 58:509–530. https://doi.org/10.1146/annurev-pharmtox-010617-052703
Caddeo C, Nacher A, Vassallo A, Armentano MF, Pons R, Fernàndez-Busquets X, Carbone C, Valenti D, Fadda AM, Manconi M (2016) Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer. Int J Pharm 513(1–2):153–163. https://doi.org/10.1016/j.ijpharm.2016.09.014
Chamundeeswari M, Jeslin J, Verma ML (2019) Nanocarriers for drug delivery applications. Environ Chem Lett 17:849–865. https://doi.org/10.1007/s10311-018-00841-1
Chang M, Wu M, Li H (2018) Antitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice. Drug Deliv 25(1):1984–1995. https://doi.org/10.1080/10717544.2018.1526227
Chaudhari VS, Borkar RM, Murty US, Banerjee S (2020a) Analytical method development & validation of reverse-phase high-performance liquid chromatography (RP-HPLC) method for simultaneous quantifications of quercetin and piperine in dual-drug loaded nanostructured lipid carriers. J Pharma Biomed Anal 186:113325. https://doi.org/10.1016/j.jpba.2020.113325
Chaudhari VS, Hazam PK, Banerjee S (2020b) Lipid nanoarchitectonics for natural products delivery in cancer therapy. In: Saneja A, Panda A, Lichtfouse E (eds) Sustainable agriculture review, vol 44. Springer, Cham. https://doi.org/10.1007/978-3-030-41842-7_5
Chen Y, Pan L, Jiang M, Li D, Jin L (2016) Nanostructured lipid carriers enhance the bioavailability and brain cancer inhibitory efficacy of curcumin both in vitro and in vivo. Drug Deliv 23(4):1383–1392. https://doi.org/10.3109/10717544.2015.1049719
Chirio D, Peira E, Dianzani C, Muntoni E, Gigliotti LC, Ferrara B, Sapino S, Chindamo G, Gallarate M (2019) Development of solid lipid nanoparticles by cold dilution of microemulsions: curcumin loading, preliminary in vitro studies, and biodistribution. Nanomaterials 9(2):230. https://doi.org/10.3390/nano9020230
Das S, Chaudhury A (2011) Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech 12(1):62–76. https://doi.org/10.1208/s12249-010-9563-0
Demain AL, Vaishnav P (2011) Natural products for cancer chemotherapy. Microb Biotechnol 4(6):687–699. https://doi.org/10.1111/j.1751-7915.2010.00221.x
Du G-H (2018) Natural small molecule drugs from plants. Springer. https://doi.org/10.1007/978-981-10-8022-7
Düzgüneş N, Gregoriadis G (2005) Introduction: the origins of liposomes: Alec Bangham at Babraham methods in enzymology, vol 391. Elsevier, pp 1–3. https://doi.org/10.1016/s0076-6879(05)91029-x
Farooq MA, Aquib M, Khan DH, Ghayas S, Ahsan A, Ijaz M, Banerjee P, Khan MA, Ahmad MM, Wang B (2019) Nanocarrier-mediated co-delivery systems for lung cancer therapy: recent developments and prospects. Environ Chem Lett 17:1565–1583. https://doi.org/10.1007/s10311-019-00897-7
Feng H, Zhu Y, Fu Z, Li D (2017) Preparation, characterization, and in vivo study of rhein solid lipid nanoparticles for oral delivery. Chem Biol Drug Des 90(5):867–872. https://doi.org/10.1111/cbdd.13007
Ghadi R, Dand N (2017) BCS class IV drugs: highly notorious candidates for formulation development. J Control Release 248:71–95. https://doi.org/10.1016/j.jconrel.2017.01.014
Gomes G, Sola M, Rochetti A, Fukumasu H, Vicente A, Pinho S (2019) β-carotene and α-tocopherol coencapsulated in nanostructured lipid carriers of murumuru (Astrocaryum murumuru) butter produced by phase inversion temperature method: characterization, dynamic in vitro digestion and cell viability study. J Microencapsul 36(1):43–52. https://doi.org/10.1080/02652048.2019
Gumireddy A, Christman R, Kumari D, Tiwari A, North EJ, Chauhan H (2019) Preparation, characterization, and in vitro evaluation of curcumin-and resveratrol-loaded solid lipid nanoparticles. AAPS PharmSciTech 20(4):145. https://doi.org/10.1208/s12249-019-1349-4
Guorgui J, Wang R, Mattheolabakis G, Mackenzie GG (2018) Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin’s lymphoma in mice. Arch Biochem Biophys 648:12–19. https://doi.org/10.1016/j.abb.2018.04.012
Huang R, Li J, Kebebe D, Wu Y, Zhang B, Liu Z (2018) Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment. Drug Deliv 25(1):757–765. https://doi.org/10.1080/10717544.2018.1446474
Jain A, Sharma G, Thakur K, Raza K, Shivhare U, Ghoshal G, Katare OP (2019) Beta-carotene-Encapsulated Solid Lipid Nanoparticles (BC-SOLID LIPID NANOPARTICLESs) as promising vehicle for cancer: an investigative assessment. AAPS PharmSciTech 20(3):100. https://doi.org/10.1208/s12249-019-1301-7
Jiang S, Zhu R, He X, Wang J, Wang M, Qian Y, Wang S (2017) Enhanced photocytotoxicity of curcumin delivered by solid lipid nanoparticles. Int J Nanomed 12:167. https://doi.org/10.2147/ijn.s123107
Jose A, Labala S, Ninave KM, Gade SK, Venuganti VVK (2018) Effective skin cancer treatment by topical co-delivery of curcumin and STAT3 siRNA using cationic liposomes. AAPS PharmSciTech 19(1):166–175. https://doi.org/10.1208/s12249-017-0833-y
Kakkar V, Kumar M, Saini K (2018) Nanoceuticals governance and market review. Environ Chem Lett 16:1293–1300. https://doi.org/10.1007/s10311-018-0754-3
Kaphle A, Navya PN, Umapathi A, Daima HK (2018) Nanomaterials for agriculture, food and environment: applications, toxicity and regulation. Environ Chem Lett 16:43–58. https://doi.org/10.1007/s10311-017-0662-y
Khosa A, Reddi S, Saha RN (2018) Nanostructured lipid carriers for site-specific drug delivery. Biomed Pharmacother 103:598–613. https://doi.org/10.1016/j.biopha.2018.04.055
Lian T, Ho RJ (2001) Trends and developments in liposome drug delivery systems. J Pharm Sci 90(6):667–680. https://doi.org/10.1002/jps.1023
Lin M, Teng L, Wang Y, Zhang J, Sun X (2016) Curcumin-guided nanotherapy: a lipid-based nanomedicine for targeted drug delivery in breast cancer therapy. Drug Deliv 23(4):1420–1425. https://doi.org/10.3109/10717544.2015.1066902
Lv L, Zhuang Y-X, Zhang H-W, Tian N-N, Dang W-Z, Wu S-Y (2017) Capsaicin-loaded folic acid-conjugated lipid nanoparticles for enhanced therapeutic efficacy in ovarian cancers. Biomed Pharmacother 91:999–1005. https://doi.org/10.1016/j.biopha.2017.04.097
Mahmud M, Piwoni A, Filiczak N, Janicka M, Gubernator J (2016) Long-circulating curcumin-loaded liposome formulations with high incorporation efficiency, stability and anticancer activity towards pancreatic adenocarcinoma cell lines in vitro. PLoS ONE 11(12):e0167787. https://doi.org/10.1371/journal.pone.0167787
Nahak P, Karmakar G, Chettri P, Roy B, Guha P, Besra SE, Soren A, Bykov AG, Akentiev AV, Noskov BA (2016) Influence of lipid core material on physicochemical characteristics of an ursolic acid-loaded nanostructured lipid carrier: an attempt to enhance anticancer activity. Langmuir 32(38):9816–9825. https://doi.org/10.1021/acs.langmuir.6b02402
Nahak P, Gajbhiye RL, Karmakar G, Guha P, Roy B, Besra SE, Bikov AG, Akentiev AV, Noskov BA, Nag K (2018) Orcinol glucoside loaded polymer-lipid hybrid nanostructured lipid carriers: potential cytotoxic agents against gastric, colon and hepatoma carcinoma cell lines. Pharm Res 35(10):198. https://doi.org/10.1007/s11095-018-2469-3
Newman DJ, Cragg GM (2016) Natural products as sources of new drugs from 1981 to 2014. J Nat Prod 79(3):629–661. https://doi.org/10.1021/acs.jnatprod.5b01055
Niazvand F, Orazizadeh M, Khorsandi L, Abbaspour M, Mansouri E, Khodadadi A (2019) Effects of quercetin-loaded nanoparticles on MCF-7 human breast cancer cells. Medicina 55(4):114. https://doi.org/10.3390/medicina55040114
Porter CJH, Trevaskis NL, Charman WN (2007) Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 6:231. https://doi.org/10.1038/nrd2197
Radhakrishnan R, Kulhari H, Pooja D, Gudem S, Bhargava S, Shukla R, Sistla R (2016) Encapsulation of biophenolic phytochemical EGCG within lipid nanoparticles enhances its stability and cytotoxicity against cancer. Chem Phys Lipids 198:51–60. https://doi.org/10.1016/j.chemphyslip.2016.05.006
Radhakrishnan R, Pooja D, Kulhari H, Gudem S, Ravuri HG, Bhargava S, Ramakrishna S (2019) Bombesin conjugated solid lipid nanoparticles for improved delivery of epigallocatechin gallate for breast cancer treatment. Chem Phys Lipids 224:104770. https://doi.org/10.1016/j.chemphyslip.2019.04.005
Riaz MK, Zhang X, Wong KH, Chen H, Liu Q, Chen X, Zhang G, Lu A, Yang Z (2019) Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy. Int J Nanomed 14:2879. https://doi.org/10.2147/ijn.s192219
Rodenak-Kladniew B, Islan GA, de Bravo MG, Durán N, Castro GR (2017) Design, characterization and in vitro evaluation of linalool-loaded solid lipid nanoparticles as potent tool in cancer therapy. Colloids Surfaces B 154:123–132. https://doi.org/10.1016/j.colsurfb.2017.03.021
Rompicharla SVK, Bhatt H, Shah A, Komanduri N, Vijayasarathy D, Ghosh B, Biswas S (2017) Formulation optimization, characterization, and evaluation of in vitro cytotoxic potential of curcumin loaded solid lipid nanoparticles for improved anticancer activity. Chem Phys Lipids 208:10–18. https://doi.org/10.1016/j.chemphyslip.2017.08.009
Sabapati M, Palei NN, Molakpogu RB (2019) Solid lipid nanoparticles of Annona muricata fruit extract: formulation, optimization and in vitro cytotoxicity studies. Drug Dev Ind Pharm 45(4):577–586. https://doi.org/10.1080/03639045.2019.1569027
Sailaja AK, Amareshwar P, Chakravarty P (2011) Formulation of solid lipid nanoparticles and their applications. Curr Pharm Res 1(2):197
Samad A, Sultana Y, Aqil M (2007) Liposomal drug delivery systems: an update review. Curr Drug Deliv 4(4):297–305. https://doi.org/10.2174/156720107782151269
Sharma A, Sharma US (1997) Liposomes in drug delivery: progress and limitations. Int J Pharm 154(2):123–140. https://doi.org/10.1016/s0378-5173(97)00135-x
Shen R, Kim JJ, Yao M, Elbayoumi TA (2016) Development and evaluation of vitamin E d-α-tocopheryl polyethylene glycol 1000 succinate-mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical. Int J Nanomed 11:1687. https://doi.org/10.2147/ijn.s103332
Shidhaye S, Vaidya R, Sutar S, Patwardhan A, Kadam V (2008) Solid lipid nanoparticles and nanostructured lipid carriers-innovative generations of solid lipid carriers. Curr Drug Deliv 5(4):324–331. https://doi.org/10.2174/156720108785915087
Shrestha H, Bala R, Arora S (2014) Lipid-based drug delivery systems. J Pharm 2014:10. https://doi.org/10.1155/2014/801820
Springob K, Kutchan TM (2009) Introduction to the different classes of natural products. Plant-derived natural products. Springer, pp 3–50. https://doi.org/10.1007/978-0-387-85498-4_1
Tang J, Ji H, Ren J, Li M, Zheng N, Wu L (2017) Solid lipid nanoparticles with TPGS and Brij 78: a co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro. Oncol Lett 13(1):389–395. https://doi.org/10.3892/ol.2016.5421
Tewari D, Rawat P, Singh PK (2019) Adverse drug reactions of anticancer drugs derived from natural sources. Food Chem Toxicol 123:522–535. https://doi.org/10.1016/j.fct.2018.11.041
Torchilin VP (2007) Micellar nanocarriers: pharmaceutical perspectives. Pharm Res 24(1):1–16. https://doi.org/10.1007/s11095-006-9132-0
Vijayakumar A, Baskaran R, Baek J-H, Sundaramoorthy P, Yoo BK (2019) In vitro cytotoxicity and bioavailability of ginsenoside-modified nanostructured lipid carrier containing curcumin. AAPS PharmSciTech 20(2):88. https://doi.org/10.1208/s12249-019-1295-1
Wang W, Zhang L, Chen T, Guo W, Bao X, Wang D, Ren B, Wang H, Li Y, Wang Y (2017) Anticancer effects of resveratrol-loaded solid lipid nanoparticles on human breast cancer cells. Molecules 22(11):1814. https://doi.org/10.3390/molecules22111814
Wang X, Wu F, Li G, Zhang N, Song X, Zheng Y, Gong C, Han B, He G (2018) Lipid-modified cell-penetrating peptide-based self-assembly micelles for co-delivery of narciclasine and siULK1 in hepatocellular carcinoma therapy. Acta Biomater 74:414–429. https://doi.org/10.1016/j.actbio.2018.05.030
Watkins R, Wu L, Zhang C, Davis RM, Xu B (2015) Natural product-based nanomedicine: recent advances and issues. Int J Nanomed 10:6055. https://doi.org/10.2147/ijn.s92162
Wissing S, Kayser O, Müller R (2004) Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 56(9):1257–1272. https://doi.org/10.1016/j.addr.2003.12.002
Xie J, Yang Z, Zhou C, Zhu J, Lee RJ, Teng L (2016) Nanotechnology for the delivery of phytochemicals in cancer therapy. Biotechnol Adv 34(4):343–353. https://doi.org/10.1016/j.biotechadv.2016.04.002
Yan H-M, Song J, Zhang Z-H, Jia X-B (2016) Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15. Drug Deliv 23(8):2911–2918. https://doi.org/10.3109/10717544.2015.1120365
Yang L, Xin J, Zhang Z, Yan H, Wang J, Sun E, Hou J, Jia X, Lv H (2016) TPGS-modified liposomes for the delivery of ginsenoside compound K against non-small cell lung cancer: formulation design and its evaluation in vitro and in vivo. J Pharm Pharmacol 68(9):1109–1118. https://doi.org/10.1111/jphp.12590
Ye H, Liu X, Sun J, Zhu S, Zhu Y, Chang S (2016) Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer. BMC Cancer 16(1):831. https://doi.org/10.1186/s12885-016-2870-4
Zhang H, Liu X, Wu F, Qin F, Feng P, Xu T, Li X, Yang L (2016) A novel prostate-specific membrane-antigen (PSMA) targeted micelle-encapsulating wogonin inhibits prostate cancer cell proliferation via inducing intrinsic apoptotic pathway. Int J Mol Sci 17(5):676. https://doi.org/10.3390/ijms17050676
Zhou X, Liu H-Y, Zhao H, Wang T (2018) RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment. Oncotargets Ther 11:5397. https://doi.org/10.2147/ott.s169555
Zielińska A, Martins-Gomes C, Ferreira NR, Silva AM, Nowak I, Souto EB (2018) Anti-inflammatory and anti-cancer activity of citral: optimization of citral-loaded solid lipid nanoparticles (SLN) using experimental factorial design and LUMiSizer®. Int J Pharm 553(1–2):428–440. https://doi.org/10.1016/j.ijpharm.2018.10.065
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Authors acknowledge the National Mission on Himalayan Studies, Ministry of Environment Forest and Climate Change, Govt. of India for providing necessary funding support.
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This work is funded through National Mission on Himalayan Studies [File Number: GBPI/NMHS-2017-18/HSF-02], Ministry of Environment Forest and Climate Change, Govt. of India. Authors are also thankful to the Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India.
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Chaudhari, V.S., Murty, U.S. & Banerjee, S. Lipidic nanomaterials to deliver natural compounds against cancer: a review. Environ Chem Lett 18, 1803–1812 (2020). https://doi.org/10.1007/s10311-020-01042-5
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DOI: https://doi.org/10.1007/s10311-020-01042-5