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Therapeutic applications of resveratrol nanoformulations

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Abstract

Resveratrol, or 3, 5, 4-trihydroxy-trans-stilbene, is a naturally occurring polyphenol present in several dietary sources such as grapes, soybeans, berries, pomegranate and peanuts. Resveratrol has received recent attention due to its diverse pharmacological activities. However, resveratrol clinical efficacy is limited due to its poor systemic bioavailability, of less than 1%, which is due to its low aqueous solubility, extensive first-pass metabolism and existence of enterohepatic recirculation. Therefore, in order to overcome these limitations, various nanocarriers including polymeric nanoparticles, solid lipid nanoparticles, liposomes, micelles and conjugates have been developed. These nanocarriers are able to enhance the bioavailability of resveratrol by modulating the P-glycoprotein, cytochrome P-450 enzymes and bypassing the hepatic first-pass effect. Here we review resveratrol nanoformulations for enhancing the efficacy of native resveratrol.

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Acknowledgements

SJ thankfully acknowledge the SERB, DST Govt. of India for Grant No. ECR/2017/001381. DA thankfully acknowledges the support in the form of research fellowships by Council of Scientific and Industrial Research (CSIR), New Delhi. The manuscript bears institutional communication No. IIIM/2151/2017.

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  1. Quality Control Quality Assurance and CMC Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India

    Divya Arora & Sundeep Jaglan

  2. Academy of Scientific and Innovative Research (AcSIR), Jammu Campus, Jammu, 180001, India

    Divya Arora & Sundeep Jaglan

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Arora, D., Jaglan, S. Therapeutic applications of resveratrol nanoformulations. Environ Chem Lett 16, 35–41 (2018). https://doi.org/10.1007/s10311-017-0660-0

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