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Cyclodextrin-based delivery systems for dietary pharmaceuticals

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Abstract

The food industry is increasingly seeking innovative solutions for enhancing the bioavailability and clinical efficacy of phytochemicals. In this regard, cyclodextrins have gained widespread attention as functional excipients. Numerous studies have demonstrated that cyclodextrin inclusion complexes enhance the apparent water solubility, physical chemical stability, and improve the bioavailability of dietary phytochemicals. Recently, the dual-encapsulation approach has been developed, which involves the complexation of dietary molecules with cyclodextrins, followed by encapsulation into nanomaterials such as liposomes, nanoparticles and conjugates. Here, we review the current applications of natural and chemically modified cyclodextrins for the delivery of dietary phytochemicals. The main emphasis is given on inclusion complexes for enhancing the solubility, bioavailability and efficacy of dietary phytochemicals. We also discuss dual-encapsulation-based approaches developed for improved efficacy of dietary phytochemicals.

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Acknowledgements

S.J. thanks the Department of Science & Technology (DST), Government of India for financial assistance via Grant No. ECR/ 2017/001381. The manuscript bears institutional communication number IIIM/2279/2019.

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Authors and Affiliations

  1. Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India

    Divya Arora & Sundeep Jaglan

  2. Academy of Scientific and Innovative Research (AcSIR), Jammu Campus, Jammu, 180001, India

    Divya Arora & Sundeep Jaglan

  3. Product Development Cell-II, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India

    Ankit Saneja

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  1. Divya Arora
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Arora, D., Saneja, A. & Jaglan, S. Cyclodextrin-based delivery systems for dietary pharmaceuticals. Environ Chem Lett 17, 1263–1270 (2019). https://doi.org/10.1007/s10311-019-00878-w

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