Résumé
Rumex nervosus Vahl est une plante utilisée traditionnellement au Yémen comme anti-inflammatoire et en traitement de la douleur. Notre étude se propose d'évaluer la toxicité aiguë et le pouvoir analgésique et central de l'extrait méthanolique de ses feuilles.
La DL50 a été évaluée à 1028 mg/kg VO, avec des limites de confiance à 95 % (723,6<DL50<1416). L'extrait révèle un effet analgésique périphérique par le test de Koster avec un pouvoir de protection notoire vis-à-vis de crampes abdominales, estimé à 32 % à 50 mg/kg VO et à 43 % à 100 mg/kg VO. Par ailleurs, un faible analgésique central morphine-like est enregistré par le test de Tail Flick à 100mg/kgVO.
Abstract
Rumex nervosus Vahl has been used traditionally for treatment of inflammatory and painful condition in Yemen. We performed the central and peripheral analgesic activity by using both pharmacological tests, Koster and tail flick.
The DL50 value is 1028 mg/kg (per os) with limits of confidence at 95% (723.6<DL50<1416).
The methanolic extract of Rumex nervosus Vahl produced an important peripheral analgesic effect, with a power of protection against the abdominal cramp, about 32% at 50 mg/kg and 43% at 100 mg/kg, via oral pathway. Moreover, a low central analgesic activity morphine like appears to 100 mg/kg.
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Alwashli, A., Al Sobarry, M., Cherrah, Y. et al. Toxicité aiguë et activité analgésique de l'extrait méthanolique de Rumex nervosus Vahl. Phytothérapie 10, 293–297 (2012). https://doi.org/10.1007/s10298-012-0727-9
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DOI: https://doi.org/10.1007/s10298-012-0727-9