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Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus

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Journal of Industrial Microbiology & Biotechnology

Abstract

Streptomyces clavuligerus produces a large array of natural compounds with antibiotic, antitumor, β-lactamase inhibition or inmunomodulating activities. The production of cephamycin C, clavulanic acid and other compounds with a clavam structure has been studied for many years. A network of regulatory mechanisms is present in S. clavuligerus to control the formation of different compounds by pathway-specific regulators or pleiotropic regulators. The possible existence of a γ-butyrolactone signaling system in this streptomycete is emerging. In addition, S. clavuligerus possesses a stringent control mechanism somehow different from those previously reported in other Streptomyces species.

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Aknowledgments

This research was supported by grants from the CICYT (Madrid) (Proyecto Bio2006-14853) and by the European Proyect LSHM-CT-2004-005224. We thank Prof. A. L. Demain for correcting the manuscript.

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  1. Instituto de Biotecnología de León, INBIOTEC, Parque Científico de León, Av. Real, 1, 24006, León, Spain

    Paloma Liras & Irene Santamarta

  2. Área de Microbiología, Fac. CC. Biológicas y Ambientales, Universidad de León, Campus de Vegazana, s/n, 24071, León, Spain

    Paloma Liras & Juan P. Gomez-Escribano

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  1. Paloma Liras
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Liras, P., Gomez-Escribano, J.P. & Santamarta, I. Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus . J Ind Microbiol Biotechnol 35, 667–676 (2008). https://doi.org/10.1007/s10295-008-0351-8

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