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Regulation of Secondary Metabolites Through Signaling Molecules in Streptomyces

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Natural Products from Actinomycetes

Abstract

The bacterial genus Streptomyces is well characterized by an ability to produce a wide variety of secondary metabolites including antibiotics, anticancer agents, antiviral drugs, herbicides, pesticides, insecticides, and immunosuppressants. Their biosynthesis is strictly controlled by small diffusible signaling molecules that constitute a signaling molecule/receptor regulatory systems. These signaling molecule/receptor regulatory systems are extensively studied in various Streptomyces species to understand the regulatory function for secondary metabolite production. This chapter focuses on the Streptomyces signaling molecules in view of structural classification, distribution, and biosynthesis. In addition, this chapter reviews the signaling molecule-dependent regulatory systems including the receptor, the target activator, and the pseudo-receptor that are responsible for controlling secondary metabolite production in Streptomyces. Application for activation of silent secondary metabolites by manipulation of regulatory systems is also briefly described.

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Authors and Affiliations

  1. Unit of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan

    Kenji Arakawa

  2. Department of Fermentation Science, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan

    Toshihiro Suzuki

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  1. Kenji Arakawa
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  2. Toshihiro Suzuki
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Correspondence to Kenji Arakawa .

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Editors and Affiliations

  1. Department of Studies in Microbiology, University of Mysore, Mysore, Karnataka, India

    Ravishankar V. Rai

  2. Department of Microbiology, School of Life Sciences, JSS AHER, Mysore, Karnataka, India

    Jamuna A. Bai

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Arakawa, K., Suzuki, T. (2022). Regulation of Secondary Metabolites Through Signaling Molecules in Streptomyces. In: Rai, R.V., Bai, J.A. (eds) Natural Products from Actinomycetes. Springer, Singapore. https://doi.org/10.1007/978-981-16-6132-7_7

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