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Altered venous capacitance as a cause of postprandial hypotension in multiple system atrophy

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Abstract

Patients with multiple system atrophy (MSA) often have clinically significant postprandial hypotension (PPH). To elucidate the cause of insufficient cardiac preload augmentation that underlies PPH, we recorded calf venous capacitance (CVC) by strain-gauge plethysmography, in 17 MSA patients and eight healthy controls before and after oral glucose ingestion. Among 17 MSA patients, nine who showed a decrease in systolic blood pressure exceeding 20 mmHg and were diagnosed with PPH. MSA patients without PPH showed a significant decrease in CVC and a significant increase in cardiac output after oral glucose ingestion, as did controls; those with MSA exhibiting PPH showed a significant increase in CVC and no significant change in cardiac output. The change in CVC correlated positively with the decrease in systolic and diastolic blood pressure after glucose ingestion, and also correlated negatively with the increase in cardiac output. Physiologically, PPH is prevented by a decrease in venous capacitance, which increases circulating blood volume and cardiac output. In some MSA patients, failure of venous capacitance to decrease may induce PPH.

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Authors and Affiliations

  1. Dept. of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan

    Motoko Takamori MD, Masaaki Hirayama MD, Hiroki Ito MD, Tomohiko Nakamura MD, Norio Hori MD & Gen Sobue MD

  2. Dept. of Neurology, Nagoya Medical Center, Nagoya, Japan

    Rei Kobayashi MD

  3. Dept. of Neurology, Okazaki Municipal Hospital, Aichi, Japan

    Naoki Mabuchi MD

  4. Dept. of Health Science, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yasuo Koike MD

Authors
  1. Motoko Takamori MD
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  2. Masaaki Hirayama MD
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  3. Rei Kobayashi MD
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  4. Hiroki Ito MD
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  5. Naoki Mabuchi MD
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  6. Tomohiko Nakamura MD
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  7. Norio Hori MD
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  8. Yasuo Koike MD
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  9. Gen Sobue MD
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Correspondence to Gen Sobue MD.

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Takamori, M., Hirayama, M., Kobayashi, R. et al. Altered venous capacitance as a cause of postprandial hypotension in multiple system atrophy. Clin Auton Res 17, 20–25 (2007). https://doi.org/10.1007/s10286-006-0378-8

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  • DOI: https://doi.org/10.1007/s10286-006-0378-8

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