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Estrogen signaling impacts temporomandibular joint and periodontal disease pathology

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Abstract

Women experience a higher incidence of oral diseases including periodontal diseases and temporomandibular joint disease (TMD) implicating the role of estrogen signaling in disease pathology. Fluctuating levels of estrogen during childbearing age potentiates facial pain, high estrogen levels during pregnancy promote gingivitis, and low levels of estrogen during menopause predisposes the TMJ to degeneration and increases alveolar bone loss. In this review, an overview of estrogen signaling pathways in vitro and in vivo that regulate pregnancy-related gingivitis, TMJ homeostasis, and alveolar bone remodeling is provided. Deciphering the specific estrogen signaling pathways for individual oral diseases is crucial for potential new drug therapies to promote and maintain healthy tissue.

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Acknowledgements

This work was supported by startup funds from the University of Kansas and NIH NIGMS P20GM103638 (JLR), NIH Predoctoral Training Program on Pharmaceutical Aspects of Biotechnology (T32-GM008359) (PMJ), and R01DE26924 (MPI-MTY, SW).

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  1. Department of Chemical and Petroleum Engineering, University of Kansas, 1530 W. 15th Street, 4132 Learned Hall, Lawrence, KS, 66045, USA

    Jennifer L. Robinson

  2. Bioengineering Graduate Program, University of Kansas, Lawrence, USA

    Jennifer L. Robinson & Pamela M. Johnson

  3. Division of Orthodontics, Columbia University College of Dental Medicine, New York, USA

    Karolina Kister, Jing Chen & Sunil Wadhwa

  4. Division of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York, USA

    Michael T. Yin

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Robinson, J.L., Johnson, P.M., Kister, K. et al. Estrogen signaling impacts temporomandibular joint and periodontal disease pathology. Odontology 108, 153–165 (2020). https://doi.org/10.1007/s10266-019-00439-1

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