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The gingiva contains leptin and leptin receptor in health and disease

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Abstract

The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters’ levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P > 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P < 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P < 0.05), with hs-CRP in G (P < 0.05) and AP groups (P < 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P < 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.

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Acknowledgments

The authors are grateful to Assoc. Prof. Dr. Ersin Uskun (Suleyman Demirel University, Faculty of Medicine, Department of Public Health) for her kind help in conducting the statistical analysis, to Jeremy Matis for English review, and to The Scientific and Technological Research Council of Turkey (TUBITAK) for supporting the study with the project number 106S187 SBAG 3435.

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Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, 32260, Isparta, Turkey

    Zuhal Yetkin Ay, F. Yeşim Kırzıoğlu & Mine Öztürk Tonguç

  2. Department of Biochemistry, Faculty of Medicine, Süleyman Demirel University, 32260, Isparta, Turkey

    Recep Sütçü

  3. Department of Pathology, Faculty of Medicine, Süleyman Demirel University, 32260, Isparta, Turkey

    Nilgün Kapucuoğlu

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  1. Zuhal Yetkin Ay
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Correspondence to Zuhal Yetkin Ay.

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Yetkin Ay, Z., Kırzıoğlu, F.Y., Öztürk Tonguç, M. et al. The gingiva contains leptin and leptin receptor in health and disease. Odontology 100, 222–231 (2012). https://doi.org/10.1007/s10266-011-0043-0

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