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Is periodontal inflamed surface area associated with serum and salivary levels of IL-1β, visfatin, and omentin-1 in overweight/obese patients?

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Abstract

Objectives

The aim of this study was to evaluate the levels of salivary and serum interleukin (IL)-1β, visfatin, and omentin-1 in the relationship between periodontal disease and overweight/obesity as well as to reveal the possible role of periodontal inflamed surface area (PISA) in this association.

Materials and methods

Ninety-six individuals (69 females, 27 males) were divided into 4 groups as systemically healthy (H) and non-periodontitis (HnP, n = 23), systemically healthy and periodontitis (HP, n = 24), overweight/obese (O) and non-periodontitis (OnP, n = 25), and overweight/obese and periodontitis (OP, n = 24). Periodontal parameters were measured, and PISA was calculated. IL-1β, visfatin, and omentin-1 levels in saliva and serum samples were analysed.

Results

Periodontal parameters deteriorated, salivary and serum IL-1β and visfatin levels were increased, and omentin-1 levels were decreased in OnP and OP groups, compared to HnP and HP groups. Salivary and serum IL-1β and visfatin levels were increased and omentin-1 levels were decreased in periodontitis groups, compared to HnP and OnP groups. PISA was negatively correlated with salivary omentin-1 and positively correlated with salivary and serum visfatin in H and O groups, whereas a positive relationship was found between PISA and salivary and serum IL-1β in H group.

Conclusions

PISA may be negatively associated with salivary omentin-1, while positively correlated with salivary and serum visfatin in overweight/obese patients.

Clinical relevance.

Co-evaluation of PISA and adipokines seems to be an innovative approach to evaluate the association between periodontitis and overweight/obesity.

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Funding

Hatay Mustafa Kemal University Scientific Research Projects Commission (Project number: 18.M.094) financially supported the current study.

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Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkey

    Esra Sinem Kemer Doğan

  2. Department of Clinical Microbiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey

    Nizami Duran

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  1. Esra Sinem Kemer Doğan
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Contributions

Conceptualization: Esra Sinem Kemer Doğan.

Formal Analysis: Esra Sinem Kemer Doğan; Nizami Duran.

Investigation: Esra Sinem Kemer Doğan.

Methodology: Esra Sinem Kemer Doğan; Nizami Duran.

Writing — original draft: Esra Sinem Kemer Doğan.

Writing — review and editing: Esra Sinem Kemer Doğan; Nizami Duran.

Corresponding author

Correspondence to Esra Sinem Kemer Doğan.

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Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. The study protocol was approved by the Hatay Mustafa Kemal University, Tayfur Ata Sökmen Medical Faculty, Clinical Research Ethics Committee (No. 2018/149).

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Written informed consent form was obtained from the patients.

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The authors declare no competing interests.

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Kemer Doğan, E.S., Duran, N. Is periodontal inflamed surface area associated with serum and salivary levels of IL-1β, visfatin, and omentin-1 in overweight/obese patients?. Clin Oral Invest 26, 5351–5358 (2022). https://doi.org/10.1007/s00784-022-04502-0

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