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Osteopenia is associated with glycemic levels and blood pressure in Chinese postmenopausal women: a cross-sectional study

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Abstract

The aim of present study was to explore the relationships between osteopenia and dyslipidemia, glycemic levels or blood pressure in postmenopausal Chinese women. A total of 4080 women aged 42–85 years were enrolled in this cross-sectional study, which was nested in an ongoing longitudinal (REACTION) study. Calcaneus quantitative ultrasound (QUS) was performed and QUS T score was calculated to assess bone mineral density. Osteopenia was defined as a T score ≤−1.0. The relationship between osteopenia and dyslipidemia, glycemic levels or blood pressure was investigated. The prevalence of osteopenia was significantly lower in subjects with systolic blood pressure (SBP) ≥140 mmHg, fasting blood glucose (FBG) ≥8.0 mmol/L, postprandial blood glucose (PBG) ≥15.0 mmol/L, hemoglobin A1c (HbA1C) 6.5–7.5 %, HbA1C ≥7.5 %. These relationships remained significant after controlling for multiple factors. Moreover, significant trend between osteopenia and SBP, FBG, PBG and HbA1C was observed in women. In contrast, no significant associations between osteopenia and diastolic blood pressure (DBP), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were found, and no significant trend relationship between osteopenia and DBP, TC, TG, HDL-C, LDL-C was found in postmenopausal Chinese women. The present study showed a relationship between SBP, FBG, PBG, HbA1C and osteopenia in postmenopausal Chinese women, while no significant relationship was observed between dyslipidemia, DBP and osteopenia, even after controlling for multiple confounding factors.

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Abbreviations

QUS:

Calcaneus quantitative ultrasound

BMI:

Body mass index

CVD:

Cardiovascular disease

SBP:

Systolic blood pressure

DBP:

Diastolic blood pressure

FBG:

Fasting blood glucose

PBG:

Postprandial blood glucose

HbA1c:

Hemoglobin A1c

SBP:

Systolic blood pressure

SOS:

Speed of sound

BUA:

Broadband ultrasound attenuation

QUI:

Quantitative ultrasound index

HDL-C:

High-density lipoprotein cholesterol

LDL-C:

Low-density lipoprotein cholesterol

OR:

Odds ratio

CI:

Confidence interval

TC:

Total cholesterol

TG:

Triglycerides

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Acknowledgments

This work was supported in part by National Science and Technology Major Project [2011ZX09307-001-08].

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Authors and Affiliations

  1. Division of Endocrinology, Department of Endocrinology, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, People’s Republic of China

    Qihong Sun, Yu Zheng, Kang Chen, Wenhua Yan, Juming Lu, Jingtao Dou, Zhaohui Lv, Baoan Wang, Weijun Gu, Jianming Ba & Yiming Mu

  2. Internal Medicine, Hospital of TCM, Fushun, 113008, Liaoning, China

    Qihong Sun

  3. School of Medicine, Nankai University, Tianjin, 300071, China

    Yu Zheng

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  1. Qihong Sun
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  2. Yu Zheng
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  3. Kang Chen
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  4. Wenhua Yan
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  5. Juming Lu
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  10. Jianming Ba
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Correspondence to Jianming Ba or Yiming Mu.

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Sun, Q., Zheng, Y., Chen, K. et al. Osteopenia is associated with glycemic levels and blood pressure in Chinese postmenopausal women: a cross-sectional study. Clin Exp Med 17, 85–91 (2017). https://doi.org/10.1007/s10238-015-0397-7

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  • DOI: https://doi.org/10.1007/s10238-015-0397-7

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