Abstract
The human aorta is a high-risk area for vascular diseases, which are commonly restored by thoracic endovascular aortic repair. In this paper, we report a promising shear-activated targeted nanoparticle drug delivery strategy to assist in the treatment of coarctation of the aorta and aortic aneurysm. Idealized three-dimensional geometric models of coarctation of the aorta and aortic aneurysm are designed, respectively. The unique hemodynamic environment of the diseased aorta is used to improve nanoparticle drug delivery. Micro-carriers with nanoparticle drugs would be targeting activated to release nanoparticle drugs by local abnormal shear stress rate (SSR). Coarctation of the aorta provides a high SSR hemodynamic environment, while the aortic aneurysm is exposed to low SSR. We propose a method to calculate the SSR thresholds for the diseased aorta. Results show that the upstream near-wall area of the diseased location is an ideal injection location for the micro-carriers, which could be activated by the abnormal SSR. Released nanoparticle drugs would be successfully targeted delivered to the aortic diseased wall. Besides, the high diffusivity of the micro-carriers and nanoparticle drugs has a significant impact on the surface drug concentrations of the diseased aortic walls, especially for aortic aneurysms. This study preliminary demonstrates the feasibility of shear-activated targeted nanoparticle drug delivery in the treatment of aortic diseases and provides a theoretical basis for developing the drug delivery system and novel therapy.
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Acknowledgements
This research was supported by the National Postdoctoral Program for Innovative Talents (CN) [Grant Number BX20200290], Postdoctoral Science Foundation (CN) [Grant Number 2020M681852], Postdoctoral Science Foundation of Zhejiang Province (CN) [Grant Number ZJ2020153].
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Qiao, Y., Wang, Y., Chen, Y. et al. Mathematical modeling of shear-activated targeted nanoparticle drug delivery for the treatment of aortic diseases. Biomech Model Mechanobiol 21, 221–230 (2022). https://doi.org/10.1007/s10237-021-01530-9
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DOI: https://doi.org/10.1007/s10237-021-01530-9