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Age and gender effects on bone mass density variation: finite elements simulation

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Abstract

Bone remodeling is a physiological process by which bone constantly adapts its structure to changes in long-term loading manifested by interactions between osteoclasts and osteoblasts. This process can be influenced by many local factors, via effects on bone cells differentiation and proliferation, which are produced by bone cells and act in a paracrine or autocrine way. The aim of the current work is to provide mechanobiological finite elements modeling coupling both cellular activities and mechanical behavior in order to investigate age and gender effects on bone remodeling evolution. A series of computational simulations have been performed on a 2D and 3D human proximal femur. An age- and gender-related impacts on bulk density alteration of trabecular bone have been noticed, and the major actors responsible of this phenomenon have been then discussed.

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Authors and Affiliations

  1. Laboratoire de Mécanique Appliquée et Ingénierie (LR-MAI), Ecole Nationale d’Ingénieurs de Tunis, LR-11-ES19, Université de Tunis El Manar, 1002, Tunis, Tunisie

    Abdelwahed Barkaoui & Rabeb Ben Kahla

  2. Laboratoire Ingénierie des Systèmes de Versailles, Université de Versailles St Quentin en Yvelines, 10 avenue del’Europe, 78140, Velizy, France

    Tarek Merzouki

  3. PRISME Laboratory, EA4229, University of Orleans Polytech’ Orléans, 8, Rue Léonard de Vinci, 45072, Orléans, France

    Ridha Hambli

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  1. Abdelwahed Barkaoui
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  2. Rabeb Ben Kahla
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  3. Tarek Merzouki
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  4. Ridha Hambli
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Correspondence to Abdelwahed Barkaoui.

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Barkaoui, A., Ben Kahla, R., Merzouki, T. et al. Age and gender effects on bone mass density variation: finite elements simulation. Biomech Model Mechanobiol 16, 521–535 (2017). https://doi.org/10.1007/s10237-016-0834-x

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  • DOI: https://doi.org/10.1007/s10237-016-0834-x

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