Skip to main content

Advertisement

SpringerLink
Log in

Use of micro-CT-based finite element analysis to accurately quantify peri-implant bone strains: a validation in rat tibiae

  • Original Paper
  • Published:
Biomechanics and Modeling in Mechanobiology Aims and scope Submit manuscript

Abstract

Although research has been addressed at investigating the effect of specific loading regimes on bone response around the implant, a precise quantitative understanding of the local mechanical response close to the implant site is still lacking. This study was aimed at validating micro-CT-based finite element (μFE) models to assess tissue strains after implant placement in a rat tibia. Small implants were inserted at the medio-proximal site of 8 rat tibiae. The limbs were subjected to axial compression loading; strain close to the implant was measured by means of strain gauges. Specimen-specific μFE models were created and analyzed. For each specimen, 4 different models were created corresponding to different representations of the bone–implant interface: bone and implant were assumed fully osseointegrated (A); a low stiffness interface zone was assumed with thickness of 40 μm (B), 80 μm (C), and 160 μm (D). In all cases, measured and computational strains correlated highly (R 2 = 0.95, 0.92, 0.93, and 0.95 in A, B, C, and D, respectively). The averaged calculated strains were 1.69, 1.34, and 1.15 times higher than the measured strains for A, B, and C, respectively, and lower than the experimental strains for D (factor = 0.91). In conclusion, we demonstrated that specimen-specific FE analyses provide accurate estimates of peri-implant bone strains in the rat tibia loading model. Further investigations of the bone-implant interface are needed to quantify implant osseointegration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Adams M (2002) Evaluation of three unstructured multigrid methods on 3D finite element problems in solid mechanics. Int J Numer Methods Eng 55: 519–534

    Article  MATH  Google Scholar 

  • Arbenz P, van Lenthe GH, Mennel U, Müller R, Sala M (2008) A scalable multi-level preconditioner for matrix-free μ-finite element analysis of human bone structures. Int J Numer Methods Eng 73: 927–947

    Article  MATH  Google Scholar 

  • Boyd SK, Muller R, Zernicke RF (2002) Mechanical and architectural bone adaptation in early stage experimental osteoarthritis. J Bone Miner Res 17(4): 687–694

    Article  Google Scholar 

  • Branemark PI, Hansson BO, Adell R, Breine U, Lindstrom J, Hallen O, Ohman A (1977) Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl 16: 1–132

    Google Scholar 

  • Brunski JB (1999) In vivo bone response to biomechanical loading at the bone/dental-implant interface. Adv Dent Res 13: 99–119

    Article  Google Scholar 

  • Carter DR, Giori NJ (1991) Effect of mechanical stress on tissue differentiation in the bony implant bed. In: Davies JE (eds) The bone-biomaterial interface. University of Toronto Press, Toronto, pp 367–376

    Google Scholar 

  • Chang MC, Ko CC, Liu CC, Douglas WH, DeLong R, Seong WJ, Hodges J, An KN (2003) Elasticity of alveolar bone near dental implant-bone interfaces after one month’s healing. J Biomech 36(8): 1209–1214

    Article  Google Scholar 

  • Davies JE (2003) Understanding peri-implant endosseous healing. J Dent Educ 67(8): 932–949

    Google Scholar 

  • De Smet E, Jaecques SV, Jansen JJ, Walboomers F, Vander SJ, Naert IE (2007) Effect of constant strain rate, composed of varying amplitude and frequency, of early loading on peri-implant bone (re)modelling. J Clin Periodontol 34(7): 618–624

    Article  Google Scholar 

  • De Smet E, Jaecques SV, Jansen JJ, Walboomers F, Vander SJ, Naert IE (2008) Effect of strain at low-frequency loading on peri-implant bone (re)modelling: a guinea-pig experimental study. Clin Oral Implants Res 19(8): 733–739

    Google Scholar 

  • De Smet E, Jaecques SVN, Wevers M, Jansen JA, Jacobs R, Sloten JV, Naert IE (2006) Effect of controlled early implant loading on bone healing and bone mass in guinea pigs, as assessed by micro-CT and histology. Eur J Oral Sci 114: 232–242

    Article  Google Scholar 

  • Duyck J, Corpas L, Vermeiren S, Ogawa T, Quirynen M, Vandamme K, Jacobs R, Naert I (2010) Histological, histomorphometrical, and radiological evaluation of an experimental implant design with a high insertion torque. Clin Oral Implants Res 21(8): 877–884

    Google Scholar 

  • Friberg B, Sennerby L, Grondahl K, Bergstrom C, Back T, Lekholm U (1999) On cutting torque measurements during implant placement: a 3-year clinical prospective study. Clin Implant Dent Relat Res 1(2): 75–83

    Article  Google Scholar 

  • Gerhard FA, Lambers FM, Kuhn G, Müller R (2008) Rigid registration allows quantification of bone formation and resorption in a longitudinal in vivo mouse study of bone adaptation. In: Annual meeting Swiss society for biomedical engineering Muttenz (Switzerland) 4–5 September, p 14

  • Huja SS, Katona TR, Burr DB, Garetto LP, Roberts WE (1999) Microdamage adjacent to endosseous implants. Bone 25(2): 217–222

    Article  Google Scholar 

  • Ko CC, Douglas WH, DeLong R, Rohrer MD, Swift JQ, Hodges JS, An KN, Ritman EL (2003) Effects of implant healing time on crestal bone loss of a controlled-load dental implant. J Dent Res 82(8): 585–591

    Article  Google Scholar 

  • Leucht P, Kim JB, Wazen R, Currey JA, Nanci A, Brunski JB, Helms JA (2007) Effect of mechanical stimuli on skeletal regeneration around implants. Bone 40(4): 919–930

    Article  Google Scholar 

  • Lioubavina-Hack N, Lang NP, Karring T (2006) Significance of primary stability for osseointegration of dental implants. Clin Oral Implants Res 17(3): 244–250

    Article  Google Scholar 

  • Matsuyama J, Ohnishi I, Sakai R, Suzuki H, Harada A, Bessho M, Matsumoto T, Nakamura K (2006) A new method for measurement of bone deformation by echo tracking. Med Eng Phys 28(6): 588–595

    Article  Google Scholar 

  • Mavrogenis AF, Dimitriou R, Parvizi J, Babis GC (2009) Biology of implant osseointegration. J Musculoskelet Neuronal Interact 9(2): 61–71

    Google Scholar 

  • Natali AN, Carniel EL, Pavan PG (2009) Dental implants press fit phenomena: biomechanical analysis considering bone inelastic response. Dent Mater 25(5): 573–581

    Article  Google Scholar 

  • Ogawa T, Possemiers T, Zhang X, Naert I, Chaudhari A, Sasaki K, Duyck J (2011) Influence of whole-body vibration time on peri-implant bone healing: a histomorphometrical animal study. J Clin Periodontol 38(2): 180–185

    Article  Google Scholar 

  • Ogawa T, Zhang X, Naert I, Vermaelen P, Deroose CM, Sasaki K, Duyck J (2011) The effect of whole-body vibration on peri-implant bone healing in rats. Clin Oral Implants Res 22(3): 302–307

    Article  Google Scholar 

  • Rubin CT, McLeod KJ (1994). Promotion of bony ingrowth by frequency-specific, low-amplitude mechanical strain. Clin Orthop Relat Res (298):165–174

  • Shalabi MM, Wolke JG, de Ruijter AJ, Jansen JA (2007) Histological evaluation of oral implants inserted with different surgical techniques into the trabecular bone of goats. Clin Oral Implants Res 18(4): 489–495

    Article  Google Scholar 

  • Tabassum A, Meijer GJ, Wolke JG, Jansen JA (2009) Influence of the surgical technique and surface roughness on the primary stability of an implant in artificial bone with a density equivalent to maxillary bone: a laboratory study. Clin Oral Implants Res 20(4): 327–332

    Article  Google Scholar 

  • Tabassum A, Walboomers XF, Wolke JG, Meijer GJ, Jansen JA (2010) Bone particles and the undersized surgical technique. J Dent Res 89(6): 581–586

    Article  Google Scholar 

  • Torcasio A, van Lenthe GH, Van OH (2008) The importance of loading frequency, rate and vibration for enhancing bone adaptation and implant osseointegration. Eur Cell Mater 16: 56–68

    Google Scholar 

  • Torcasio A, Zhang X, Duyck J, van Lenthe GH (2011) 3D characterization of bone strains in the rat tibia loading model. Biomech Model Mechanobiol. doi:10.1007/s10237-011-0320-4

  • van Lenthe GH, Müller R (2008) CT-based visualization and quantification of boe microstructure in vivo. IBMS BoneKEy 5(11): 410–425

    Article  Google Scholar 

  • van Lenthe GH, Voide R, Boyd SK, Muller R (2008) Tissue modulus calculated from beam theory is biased by bone size and geometry: implications for the use of three-point bending tests to determine bone tissue modulus. Bone 43(4): 717–723

    Article  Google Scholar 

  • van Rietbergen B, Weinans H, Huiskes R, Odgaard A (1995) A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J Biomech 28(1): 69–81

    Article  Google Scholar 

  • Warreth A, Polyzois I, Lee CT, Claffey N (2009) Generation of microdamage around endosseous implants. Clin Oral Implants Res 20(12): 1300–1306

    Article  Google Scholar 

  • Wirth AJ, Mueller TL, Vereecken W, Flaig C, Arbenz P, Müller R, van Lenthe GH (2010) Mechanical competence of bone-implant systems can accurately be determined by image-based micro-finite element analyses. Arch Appl Mech 80: 513–525

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biomechanics Section, Department of Mechanical Engineering, K.U.Leuven, Celestijnenlaan 300C, 3001, Leuven, Belgium

    Antonia Torcasio, Hans Van Oosterwyck & G. Harry van Lenthe

  2. Institute for Biomechanics, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093, Zurich, Switzerland

    G. Harry van Lenthe

  3. BIOMAT, Department of Prosthetic Dentistry, K.U.Leuven, Kapucijnenvoer 7, 3000, Leuven, Belgium

    Xiaolei Zhang & Joke Duyck

Authors
  1. Antonia Torcasio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaolei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hans Van Oosterwyck
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Joke Duyck
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Harry van Lenthe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. Harry van Lenthe.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Torcasio, A., Zhang, X., Van Oosterwyck, H. et al. Use of micro-CT-based finite element analysis to accurately quantify peri-implant bone strains: a validation in rat tibiae. Biomech Model Mechanobiol 11, 743–750 (2012). https://doi.org/10.1007/s10237-011-0347-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10237-011-0347-6

Keywords

Search

Navigation