Abstract
The incidence of tuberculosis (TB) disease has increased in Norway since the mid-1990s. Immigrants are screened, and some are treated, for latent TB infection (LTBI) to prevent TB disease (reactivation). In this study, we estimated the costs of both treating and screening for LTBI and TB disease, which has not been done previously in Norway. We developed a model to indicate the cost-effectiveness of four different screening algorithms for LTBI using avoided TB disease cases as the health outcome. Further, we calculated the expected value of perfect information (EVPI), and indicated areas of LTBI screening that could be changed to improve cost-effectiveness. The costs of treating LTBI and TB disease were estimated to be €1938 and €15,489 per case, respectively. The model evaluates four algorithms, and suggests three cost-effective algorithms depending on the cost-effectiveness threshold. Screening all immigrants with interferon-gamma release assays (IGRA) requires the highest threshold (€28,400), followed by the algorithms “IGRA on immigrants with risk factors” and “no LTBI screening.” EVPI is approximately €5 per screened immigrant. The costs for a cohort of 20,000 immigrants followed through 10 years range from €12.2 million for the algorithm “screening and treatment for TB disease but no LTBI screening,” to €14 million for “screening all immigrants for both TB disease and LTBI with IGRA.” The results suggest that the cost of TB disease screening and treatment is the largest contributor to total costs, while LTBI screening and treatment costs are relatively small. Increasing the proportion of IGRA-positive immigrants who are treated decreases the costs per avoided case substantially.
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References
Merck: Tuberculosis (TB). http://www.merckmanuals.com/professional/infectious_diseases/mycobacteria/tuberculosis_tb.html. (2009). Accessed 7 November 2013
World Health Organization: Global tuberculosis report 2015. WHO http://www.who.int/tb/publications/global_report/en/ (2016). Accessed 13 January 2016
Dye, C., Scheele, S., Dolin, P., Pathania, V., Raviglione, M. C., for the W. H. O. G. S., & Monitoring Project. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. JAMA. 282(7), 677–686 (1999)
Dagnew, A., Hussein, J., Abebe, M., Zewdie, M., Mihret, A., Bedru, A., Aseffa, A.: Diagnosis of latent tuberculosis infection in healthy young adults in a country with high tuberculosis burden and BCG vaccination at birth. BMC Res Notes 5(1), 415 (2012)
Norwegian Institute of Public Health: Guide on tuberculosis. http://www.fhi.no/eway/default.aspx?pid=239&trg=Main_6157&Main_6157=7139:0:25,5500 (2013). Accessed 7 November 2013
Lin, P.L., Flynn, J.L.: Understanding latent tuberculosis: a moving target. J. Immunol. 185(1), 15–22 (2010)
Arnesen, T.M., Eide, K.Å., Norheim, G., Mengshoel, A.T., Sandbu, S., Winje, B.: Tuberculosis in Norway 2013—with treatment results for 2012. Norwegian Institute of Public Health. Oslo, Norway (2014)
Norwegian Institute of Public Health: Countries with high occurrence of tuberculosis. http://www.fhi.no/eway/default.aspx?pid=240&trg=Content_6671&Main_6664=6894:0:25,7555:1:0:0:::0:0&MainContent_6894=6671:0:25,7570:1:0:0:::0:0&List_6673=6674:0:25,7574:1:0:0:::0:0&Content_6671=6683:105433::1:6682:1:::0:0 (2014). Accessed 27 August 2014
Regulations on tuberculosis control. https://lovdata.no/dokument/SF/forskrift/2009-02-13-205?q=forskrift+om+tuberkulosekontroll (2009). Accessed 7 July 2015
Norwegian Institute of Public Health: Simplified tuberculosis control. http://www.fhi.no/artikler/?id=110976 (2014). Accessed 2 September 2014
Diel, R., Loddenkemper, R., Nienhaus, A.: Predictive value of interferon-γ release assays and tuberculin skin testing for progression from latent TB infection to disease state: a meta-analysis. Chest J 142(1), 63–75 (2012)
Nienhaus, A., Schablon, A., Costa, J.T., Diel, R.: Systematic review of cost and cost-effectiveness of different TB-screening strategies. BMC Health Serv Res 11, 247 (2011)
Campbell, J.R., Sasitharan, T., Marra, F.: A systematic review of studies evaluating the cost utility of screening high-risk populations for latent tuberculosis infection. Appl Health Econ Health Policy. 13(4), 325–340 (2015)
Haukaas, F. S.: Screening immigrants for latent tuberculosis: a cost-effectiveness analysis in a Norwegian setting. Master’s thesis, University of Oslo, Oslo. http://urn.nb.no/URN:NBN:no-44714 (2014). Accessed 7 July 2015
Winje, B., Oftung, F., Korsvold, G., Mannsåker, T., Jeppesen, A., Harstad, I., Heldal, E.: Screening for tuberculosis infection among newly arrived asylum seekers: comparison of QuantiFERON®TB Gold with tuberculin skin test. BMC Infect Dis 8(1), 1–10 (2008)
Harstad, I., Heldal, E., Steinshamn, S., Garasen, H., Jacobsen, G.: Tuberculosis screening and follow-up of asylum seekers in Norway: a cohort study. BMC Public Health 9(1), 141 (2009)
Olsen, A.I.M., Andersen, H.E., Aßmus, J., Djupvik, J.A., Gran, G., Skaug, K., Mørkve, O.: Management of latent tuberculous infection in Norway in 2009: a descriptive cross-sectional study. Public Health Action 3(2), 166–171 (2013)
Briggs, A., Claxton, K., Sculpher, M.: Decision modelling for health economic evaluation. Oxford University Press, New York (2006)
Wiker, H., Mustafa, T., Bjune, G., Harboe, M.: Evidence for waning of latency in a cohort study of tuberculosis. BMC Infect. Dis. 10(1), 37 (2010)
The Norwegian Directorate of Health. Economic evaluation of health technologies—a guide: The Norwegian Directorate of Health. https://helsedirektoratet.no/Lists/Publikasjoner/Attachments/624/Okonomisk-evaluering-av-helsetiltak-IS-1985.pdf (2012). Accessed 11 July 2015
Regulations on expenses for outpatient services. http://lovdata.no/dokument/LTI/forskrift/2013-12-12-1503 (2013). Accessed 24 April 2014
Statistics Norway: Salary for employees in the health trusts. http://www.ssb.no/arbeid-og-lonn/statistikker/lonnstasyk (2013). Accessed 30 January 2014
Norwegian Medical Association: Normaltariff for fastleger og legevakt 2013–2014. http://normaltariffen.legeforeningen.no/pdf/Fastlegetariff_2013.pdf (2013). Accessed 7 July 2014
Regulations on coverage of laboratory expenses. http://lovdata.no/dokument/LTI/forskrift/2013-12-17-1562 (2013). Accessed 24 April 2014
Norwegian Medicines Agency: Legemiddelsøk. http://www.legemiddelverket.no/Legemiddelsoek/Sider/default.aspx (2014). Accessed 17 March 2014
The Norwegian Directorate of Health: Innsatsstyrt finansiering 2013. http://www.helsedirektoratet.no/publikasjoner/innsatsstyrt-finansiering-2013/Publikasjoner/IS-2041_web.pdf (2012). Accessed 7 March 2014
Barton, G.R., Briggs, A.H., Fenwick, E.A.L.: Optimal cost-effectiveness decisions: the role of the cost-effectiveness acceptability curve (CEAC), the cost-effectiveness acceptability frontier (CEAF), and the expected value of perfection information (EVPI). Value Health 11(5), 886–897 (2008)
Oxlade, O., Pinto, M., Trajman, A., Menzies, D.: How methodologic differences affect results of economic analyses: a systematic review of interferon gamma release assays for the diagnosis of LTBI. PLoS One 8(3), e56044 (2013)
Ena, J., Valls, V.: Short-course therapy with rifampin plus isoniazid, compared with standard therapy with isoniazid, for latent tuberculosis infection: a meta-analysis. Clin. Infect. Dis. 40(5): 670–676 (2005). http://cid.oxfordjournals.org/content/40/5/670.full.pdf
Rennie, T. W., Bothamley, G. H., Engova, D., Bates, I. P.: Patient choice promotes adherence in preventive treatment for latent tuberculosis. Eur. Respir. J. 30(4): 728–735 (2007). http://www.ncbi.nlm.nih.gov/pubmed/17626113
Spyridis, N. P., Spyridis, P. G., Gelesme, A., Sypsa, V., Valianatou, M., et al.: The effectiveness of a 9-month regimen of isoniazid alone versus 3- and 4-month regimens of isoniazid plus rifampin for treatment of latent tuberculosis infection in children: results of an 11-year randomized study. Clin. Infect. Dis. 45(6): 715–722 (2007). http://www.ncbi.nlm.nih.gov/pubmed/17712755
Pareek, M., Watson, J.P., Ormerod, L.P., Kon, O.M., Woltmann, G., White, P.J., Lalvani, A.: Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis. Lancet Infect Dis 11(6), 435–444 (2011)
Erkens, C.G.M., Dinmohamed, A.G., Kamphorst, M., Toumanian, S., van Nispen-Dobrescu, R., Alink, M., Oudshoorn, N., Mensen, M., van den Hof, S., Borgdorff, M., Verver, S.: Added value of interferon-gamma release assays in screening for tuberculous infection in the Netherlands. Int. J. Tuberc. Lung Dis. 18(4), 413–420 (2014)
Mulder, C.: Tuberculosis control among immigrants. In: Mulder, C. (ed) Factulteit der Geneeskunde (2013)
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The study received no funding. The work was conducted while FSH was employed as an intern at the Norwegian Institute of Public Health, and was done as part of FSH’s master’s thesis.
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The authors declare that they have no conflict of interest. FSH is currently an employee of Biogen Norway AS, but Biogen Norway AS had no involvement with the research or the article. The research and the majority of the writing of the article were conducted before FSH was employed by Biogen Norway AS.
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Haukaas, F.S., Arnesen, T.M., Winje, B.A. et al. Immigrant screening for latent tuberculosis in Norway: a cost-effectiveness analysis. Eur J Health Econ 18, 405–415 (2017). https://doi.org/10.1007/s10198-016-0779-0
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DOI: https://doi.org/10.1007/s10198-016-0779-0
Keywords
- Latent tuberculosis
- Cost-effectiveness analysis
- CEA
- Screening
- Immigrants
- Expected value of perfect information
- EVPI
- Economic evaluation
- IGRA
- TST
- Tuberculin skin test
- Interferon gamma release assay
- Norway
- Tuberculosis