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Sleep debt and prevalence of proteinuria in subjects with short sleep duration on weekdays: a cross-sectional study

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Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

Study objective

Short sleep duration is a risk factor of chronic kidney disease, along with cardiovascular diseases and all-cause mortality. Several studies reported that many people sleep longer on weekends than on weekdays, suggesting that they should be compensated for their sleep debt on weekdays on the weekends. Few studies have reported the clinical impact of sleep debt on the kidney.

Methods

This cross-sectional study included 5799 employees of Osaka University who visited its Health Care Center for their annual health examinations and answered ≤ 6 h of sleep duration on weekdays. The independent variable was the sleep debt index defined as a gap in self-reported sleep duration (≤ 5, 5–6, 6–7, 7–8, 8–9, and ≥ 9 h) between weekdays and weekends, which was categorized into ≤ 0, + 1, + 2, + 3 and ≥+4. An association between the sleep debt index and a prevalence of proteinuria defined as dipstick proteinuria of ≥ 1 + was assessed using logistic regression models adjusting for clinically relevant factors.

Results

More than four-fifths of the subjects had a positive sleep debt index (≤ 0, + 1, + 2, + 3, and ≥+4 recorded for 19%, 36%, 28%, 11%, and 6%, respectively). The multivariable-adjusted logistic regression models showed the sleep debt index ≥ 3 + was significantly associated with the prevalence of proteinuria (sleep debt index ≤ 0, adjusted odds ratio 1.13 [0.77, 1.65]; + 1, 1.00 [reference]; + 2, 1.29 [0.93, 1.79]; + 3, 1.54 [1.02, 2.33]; ≥ + 4, 1.87 [1.15, 3.05]).

Conclusions

Sleep debt was associated with the prevalence of proteinuria in a dose-dependent manner.

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Acknowledgements

We thank all the staff members of Health and Counseling Center, Osaka University for their contributions to the database of the present cohort.

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Authors and Affiliations

  1. Department of Nephrology, Osaka University Graduate School of Medicine, 2-2-D11 Yamadaoka, Suita, 565-0871, Japan

    Katsunori Aoki, Ryohei Yamamoto, Maki Shinzawa, Yoshiki Kimura, Yoshiyuki Fujii, Ryohei Tomi, Yoshitaka Isaka & Toshiki Moriyama

  2. Health Care Division, Health and Counseling Center, Osaka University, 1-17 Machikaneyama-cho, Toyonaka, Osaka, 560-0043, Japan

    Ryohei Yamamoto, Hiroyoshi Adachi, Kaori Nakanishi, Manabu Taneike, Makoto Nishida, Takashi Kudo, Keiko Yamauchi-Takihara & Toshiki Moriyama

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  1. Katsunori Aoki
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Corresponding author

Correspondence to Ryohei Yamamoto.

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Conflict of interest

All the authors have declared no competing interest.

Ethical approval

The study protocol was approved by the ethics committees of Osaka University Health and Counseling Center (No. 2016-1) and Osaka University Hospital (No. 17009-2).

Informed consent

Informed consent was not obtained from participants, according to Japanese Ethical Guidelines for Medical and Health Research Involving Human Subjects.

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Aoki, K., Yamamoto, R., Shinzawa, M. et al. Sleep debt and prevalence of proteinuria in subjects with short sleep duration on weekdays: a cross-sectional study. Clin Exp Nephrol 24, 143–150 (2020). https://doi.org/10.1007/s10157-019-01808-4

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  • DOI: https://doi.org/10.1007/s10157-019-01808-4

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