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Association between sleep duration and nephropathy in patients with type II diabetes mellitus

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Abstract

Sleep disturbances have been shown to be associated with adverse health outcomes including diabetes mellitus (DM), hypertension, and obesity. However, little is known about the relationship between sleep duration and diabetes complications. The present cross-sectional study aimed to examine the association between sleep duration and nephropathy in a population of type 2 DM patients. Diabetic patients aged ≥ 18 years who visited two outpatient clinics in Kermanshah from February 2014 to February 2015 entered the study. Demographic, anthropometric, and biochemical data, as well as information on sleep duration of participants within the past 4 weeks, were collected by an interviewer. Patients with estimated glomerular filtration rate (eGFR) ≤ 60 ml/24 h were excluded from the study. Proteinuria was defined as excretion of more than 150 mg protein in 24-h urine. Differences in urine protein and related variables were examined between four sleep duration groups (≤ 5, 6, 7, and ≥ 8 h). Linear and logistic regression analyses were employed to assess the association between sleep duration and diabetic nephropathy. Four hundred thirty-two patients (63.8% female) with a mean age of 54.68 ± 9.98 years were analyzed. There were statistically significant differences in age, body mass index, waist circumference, DM duration, HbA1C, total cholesterol, HDL cholesterol, triglyceride, uric acid, and urine protein between sleep duration groups. While adjusted linear regression showed no association between sleep duration and urine protein (p = 0.300), multivariable logistic regression revealed male gender, increased HbA1C, shorter sleep duration, increased DM duration, lower eGFR, higher DBP, decreased HDL-C, and higher uric acid levels to be statistically associated with proteinuria. Short sleep duration is adversely associated with proteinuria in type 2 DM patients with normal and near-normal kidney function.

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Acknowledgements

The authors wish to express their gratitude to all who participated in this study. The work was performed in partial fulfillment of the requirements for degree of Specialty in Internal Medicine of Tahereh Yavari M.D., in Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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Authors and Affiliations

  1. Department of Internal Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Rozita Naseri

  2. School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Tahereh Yavari

  3. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Anita Eftekharzadeh

  4. Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), PO Box: 6719851151, Kermanshah, Iran

    Habibolah Khazaie

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  1. Rozita Naseri
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  4. Habibolah Khazaie
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Correspondence to Habibolah Khazaie.

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All patients signed a written informed consent after receiving full explanation on details and objectives of the study. The study was approved by the Ethics Committee of Kermanshah University of Medical Sciences. Data were collected anonymously and all principles of Helsinki’s Declaration were met throughout the study phases.

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The authors declare that they have no conflict of interest.

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Naseri, R., Yavari, T., Eftekharzadeh, A. et al. Association between sleep duration and nephropathy in patients with type II diabetes mellitus. Int J Diabetes Dev Ctries 38, 375–380 (2018). https://doi.org/10.1007/s13410-017-0603-0

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  • DOI: https://doi.org/10.1007/s13410-017-0603-0

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