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Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays

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Abstract

Objective

The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays.

Methods

Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges.

Results

For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15–16 years. The median serum cystatin C levels in children aged 12–16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured.

Conclusion

Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.

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Acknowledgments

This study was financially supported by the Kidney Foundation, Japan. We thank Midori Awazu, MD; Takashi Sekine, MD; Mayumi Sako, MD; Takuji Yamada, MD; and Yuko Akioka, MD of the Committee of Measures for Pediatric CKD, for their contributions to the conception and design of this study. None of the funding sources had any role in the design or conduct of the study; in the collection, management, analysis, or interpretation of the data, or in the preparation, review, or approval of this manuscript. The authors declare that no conflict of interest exists.

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Authors and Affiliations

  1. The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan

    Nahoko Yata, Osamu Uemura, Masataka Honda, Takeshi Matsuyama, Kenji Ishikura, Hiroshi Hataya, Takuhito Nagai, Yohei Ikezumi, Naoya Fujita, Shuichi Ito & Kazumoto Iijima

  2. Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan

    Mari Saito & Tetsuji Keneko

  3. Tokyo Health Service Association, Tokyo, Japan

    Teruo Kitagawa

  4. Department of Clinical Research, Tokyo Metropolitan Children’s Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 204-8561, Japan

    Nahoko Yata

Authors
  1. Nahoko Yata
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  2. Osamu Uemura
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  3. Masataka Honda
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  4. Takeshi Matsuyama
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  5. Kenji Ishikura
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  6. Hiroshi Hataya
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  7. Takuhito Nagai
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  8. Yohei Ikezumi
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  9. Naoya Fujita
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  10. Shuichi Ito
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  11. Kazumoto Iijima
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  12. Mari Saito
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  13. Tetsuji Keneko
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  14. Teruo Kitagawa
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Corresponding author

Correspondence to Nahoko Yata.

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Yata, N., Uemura, O., Honda, M. et al. Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays. Clin Exp Nephrol 17, 872–876 (2013). https://doi.org/10.1007/s10157-013-0784-x

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  • DOI: https://doi.org/10.1007/s10157-013-0784-x

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