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Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels

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Abstract

Background

Oxidative stress (OS) is a strong risk factor for cardiovascular disease (CVD). The incidence of CVD is lower among kidney transplantation (KT) recipients than hemodialysis patients, and the reduction in OS may be one reason for this difference. Recently, serum sulfatides were recognized as a candidate inhibitory factor of CVD affected by OS. However, the long-term changes in OS and serum sulfatide levels in KT recipients are unknown.

Methods

We investigated the long-term changes in a serum OS marker, malondialdehyde (MDA), and the serum sulfatide levels in 17 KT recipients. Multiple regression analysis was used to analyze the factors correlated with serum sulfatide levels.

Results

The high serum levels of MDA in the KT recipients decreased dramatically but were still high 1 year after KT surgery. MDA levels decreased further and reached near-normal levels more than 3 years after the surgery. Similarly, over the same 3 years, the low serum sulfatide levels increased to near-normal levels, reaching saturation. Multiple regression analysis showed that the most significant factors influencing serum sulfatide levels were MDA and total cholesterol content.

Conclusions

The current results show that over the long term, the internal improvement brought about by successful KT can normalize OS. Oxidative normalization was significantly correlated with the restoration of serum sulfatide levels, which were also influenced by lipoprotein metabolism. The amelioration of serum sulfatide levels might contribute to the low incidence of CVD in KT recipients.

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Acknowledgments

This work was supported in part by GL Sciences (Tokyo, Japan) and the Shinshu Public Utility Foundation (Matsumoto, Japan).

Conflict of interest

The authors have declared that no conflict of interest exists.

Author information

Authors and Affiliations

  1. Department of Nephrology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Yuji Kamijo, Koji Hashimoto & Makoto Higuchi

  2. Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Yuji Kamijo, Lixuan Wang, Takero Nakajima, Koji Hashimoto, Toshifumi Aoyama & Atsushi Hara

  3. Department of Histology and Embryology, Hebei Medical University, 361 Zhong Shan East Road, Shijiazhuang, Hebei, 050017, China

    Lixuan Wang

  4. Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Akihiro Matsumoto

  5. Division of Microbiology and Molecular Cell Biology, Nihon Pharmaceutical University, 10281 Komuro, Inamachi, Kita-Adachigun, Saitama, 362-0806, Japan

    Mamoru Kyogashima

Authors
  1. Yuji Kamijo
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  2. Lixuan Wang
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  3. Akihiro Matsumoto
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  4. Takero Nakajima
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  5. Koji Hashimoto
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  6. Makoto Higuchi
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  7. Mamoru Kyogashima
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  8. Toshifumi Aoyama
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  9. Atsushi Hara
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Corresponding author

Correspondence to Yuji Kamijo.

Additional information

Y. Kamijo and L. Wang contributed equally to this work.

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Kamijo, Y., Wang, L., Matsumoto, A. et al. Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels. Clin Exp Nephrol 16, 959–967 (2012). https://doi.org/10.1007/s10157-012-0634-2

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  • DOI: https://doi.org/10.1007/s10157-012-0634-2

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