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Correlation between oxidative stress and immunosuppressive therapy in renal transplant recipients with an uneventful postoperative course and stable renal function

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Abstract

Background

Reactive oxygen species (ROS) are important mediators of cellular damage and lipid peroxidation is the most important expression of ROS-induced oxidative stress. Recent studies have suggested that increased plasma malondialdehyde (MDA) levels are a consequence of specific immunosuppressive therapies. This study aims at investigating the relation between oxidative stress and immunosuppressive therapies in renal transplant patients with stable renal function and uneventful postoperative course.

Methods

The study group included 26 renal patients. Two groups of renal transplant recipients, treated with a different combination of immunosuppressive agents were studied (Group A: CyA, MMF, Steroids and Basiliximab, Group B: Tacrolimus, MMF, Steroids and Daclizumab). All patients had an uneventful postoperative course. Plasma MDA levels were measured before transplantation, 1 and 6 months after. Plasma concentration of endogenous creatinine (Cr) was used as a measure of stable renal function.

Results

Levels of MDA were increased before the transplantation in all renal patients (MDA: 7.81 ± 4.81, normal levels: 2.23–4.08 nmol/ml, P < 0.05). Combined therapy with CyA was associated with high values of MDA at 6 months measurement after transplantation. However this tendency of increased MDA levels did not achieve a statistical significance (Group A: 6.97 vs. 9.06 nmol/ml, P>0.05). On the contrary, statistically significant diminution of MDA levels was observed in Group B patients (Tacrolimus–MMF–steroids) at 6 months measurement after transplantation. (Group B: 8.61 vs. 4.11 nmol/ml, P<0.02<0.05).

Conclusions

Immunosuppressive combined therapy with CyA was associated with the high values of MDA that were measured posttransplantly. Our study provides strong evidence that Tacrolimus is significantly associated with improved free radical metabolism.

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Abbreviations

ROS:

Reactive oxygen species

References

  1. A Demirbas S Bozoklu A Ozdemir N Bilgin M Haberal (1993) ArticleTitleEffect of alpha-tocopherol on the prevention of reperfusion injury caused by free oxygen radicals in the canine kidney autotransplantation model Transplant Proc 25 IssueID3 2274 Occurrence Handle8516898 Occurrence Handle1:STN:280:ByyB1MnpsVw%3D

    PubMed  CAS  Google Scholar 

  2. JP Bantle MS Paller RJ Boudreau MT Olivari TF Ferris (1990) ArticleTitleLong-term effects of cyclosporine on renal function in organ transplant recipients J Lab Clin Med 115 IssueID2 233–240 Occurrence Handle2405085 Occurrence Handle1:STN:280:By%2BC3s3itVc%3D

    PubMed  CAS  Google Scholar 

  3. R Hower T Minor H Schneeberger J Theodorakis S Rembold WD Illner et al. (1996) ArticleTitleAssessment of oxygen radicals during kidney transplantation—effect of radical scavenger Transpl Int 9 IssueIDSuppl 1 S479–S482 Occurrence Handle8959891 Occurrence Handle1:CAS:528:DyaK2sXjtV2jsg%3D%3D

    PubMed  CAS  Google Scholar 

  4. Klin W (1991) Dec 15; 69(21–23):1050–1055. Erratum In Klin W (1990) Dec 30; 69(24):1185

  5. EL Greene MS Paller (1991) ArticleTitleOxygen free radicals in acute renal failure Miner Electrolyte Metab 17 IssueID2 124–132 Occurrence Handle1753921 Occurrence Handle1:CAS:528:DyaK38XhtVensbg%3D

    PubMed  CAS  Google Scholar 

  6. E Tatou C Mossiat V Maupoil F Gabrielle M David L Rochette (1996) ArticleTitleEffects of cyclosporine and cremophor on working rat heart and incidence of myocardial lipid peroxidation Pharmacology 52 IssueID1 1–7 Occurrence Handle8966197 Occurrence Handle1:CAS:528:DyaK28XksFyguw%3D%3D Occurrence Handle10.1159/000139354

    Article  PubMed  CAS  Google Scholar 

  7. A. Haberland W. Henke T. Grune et al. (1997) ArticleTitleDifferential response of oxygen radical metabolism in rat heart, liver and kidney to cyclosporine A treatment Inflamm Res 46 452–454 Occurrence Handle9427065 Occurrence Handle1:CAS:528:DyaK2sXnsFGjtLs%3D Occurrence Handle10.1007/s000110050223

    Article  PubMed  CAS  Google Scholar 

  8. JA Knight AK Cheung RK Pieper K Servilla (1989) ArticleTitleIncreased urinary lipoperoxide levels in renal transplant patients Ann Clin Lab Sci 19 IssueID4 238–241 Occurrence Handle2667454 Occurrence Handle1:STN:280:BiaA3svivVw%3D

    PubMed  CAS  Google Scholar 

  9. F Romero J Herrera M Nava B Rodriguez-Iturbe (1999) ArticleTitleOxidative stress in renal transplantation with uneventful postoperative course Transplant Proc 31 IssueID6 2315–2316 Occurrence Handle10500595 Occurrence Handle1:STN:280:DyaK1MvjtVersA%3D%3D Occurrence Handle10.1016/S0041-1345(99)00356-5

    Article  PubMed  CAS  Google Scholar 

  10. J Pincemail JO Defraigne C Franssen P Bonnet G Deby-Dupont J Pirenne et al. (1993) ArticleTitleEvidence for free radical formation during human kidney transplantation Free Radic Biol Med 15 IssueID3 343–348 Occurrence Handle8406134 Occurrence Handle1:STN:280:ByuD3M%2FksVY%3D Occurrence Handle10.1016/0891-5849(93)90081-5

    Article  PubMed  CAS  Google Scholar 

  11. A Davenport M Hopton C Bolton (1995) ArticleTitleMeasurement of malondialdehyde as a marker of oxygen free radical production during renal allograft transplantation and the effect on early graft function Clin Transplant 9 IssueID3 Pt 1 171–175 Occurrence Handle7549056 Occurrence Handle1:STN:280:BymD383osFU%3D

    PubMed  CAS  Google Scholar 

  12. S Simic-Ogrizovic T Simic Z Reljic S Markovic R Blagojevic D Radivojevic et al. (1998) ArticleTitleMarkers of oxidative stress after renal transplantation Transpl Int 11 IssueIDSuppl 1 S125–S129 Occurrence Handle9664961 Occurrence Handle10.1007/s001470050443

    Article  PubMed  Google Scholar 

  13. JP Cristol C Vela MF Maggi et al. (1998) ArticleTitleOxidative stress and lipid abnormalities in renal transplant recipients with or without chronic rejection Transplantation 65 IssueID10 1322–1328 Occurrence Handle9625013 Occurrence Handle1:STN:280:DyaK1c3os1KktQ%3D%3D Occurrence Handle10.1097/00007890-199805270-00007

    Article  PubMed  CAS  Google Scholar 

  14. I Ceballos-Picot V Witko-Sarsat M Merad-Boudia AT Nguyen M Thevenin MC Jaudon et al. (1996) ArticleTitleGlutathione antioxidant system as a marker of oxidative stress in chronic renal failure Free Radic Biol Med 21 IssueID6 845–853 Occurrence Handle8902530 Occurrence Handle1:CAS:528:DyaK28XmsFyhurg%3D Occurrence Handle10.1016/0891-5849(96)00233-X

    Article  PubMed  CAS  Google Scholar 

  15. CM Loughrey IS Young JH Lightbody D McMaster PT McNamee ER Trimble (1994) ArticleTitleOxidative stress in haemodialysis QJM 87 IssueID11 679–683 Occurrence Handle7820542 Occurrence Handle1:STN:280:ByqC38%2Fks1U%3D

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory for Experimental Surgery and Surgical Research, School of Medicine, Athens University, Athens, Greece

    Despina N. Perrea, Maria V. Poulakou & Ioannis S. Vlachos

  2. 2nd Department of Propedeutic Surgery, School of Medicine, Athens University, “Laiko” Hospital, Athens, Greece

    Konstantinos G. Moulakakis, Antonios Papachristodoulou & Alkiviadis I. Kostakis

Authors
  1. Despina N. Perrea
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  2. Konstantinos G. Moulakakis
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  3. Maria V. Poulakou
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  4. Ioannis S. Vlachos
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  5. Antonios Papachristodoulou
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  6. Alkiviadis I. Kostakis
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Correspondence to Konstantinos G. Moulakakis.

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Perrea, D.N., Moulakakis, K.G., Poulakou, M.V. et al. Correlation between oxidative stress and immunosuppressive therapy in renal transplant recipients with an uneventful postoperative course and stable renal function. Int Urol Nephrol 38, 343–348 (2006). https://doi.org/10.1007/s11255-006-0054-x

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  • DOI: https://doi.org/10.1007/s11255-006-0054-x

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