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Weight gain after 20 years of age is associated with prevalence of chronic kidney disease

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Abstract

Background

Weight gain after maturity is a risk factor for diabetes, coronary heart disease, and stroke, even in individuals with a normal body mass index; however, there is little information about the influence of weight gain after maturity on chronic kidney disease (CKD). Therefore, we examined the association between weight gain after 20 years of age and the prevalence of CKD.

Methods

A cross-sectional study was performed on 28,151 women and 21,110 men aged between 40 and 59 years who participated in the specific health check and guidance system of Japan in 2008. We compared prevalence of CKD between participants with and without weight gain of at least 10 kg after 20 years of age. Multivariate logistic regression models and stratified analyses were used to adjust for possible confounding factors.

Results

The prevalence of CKD among participants with weight gain was significantly higher than among those without weight gain both in women (11.8 vs 8.3%, p < 0.0001) and in men (12.2 vs 9.2%, p < 0.0001). After adjustment for age, smoking, regular exercise, alcohol intake, history of kidney disease, hypertension, diabetes, and hypercholesterolemia, the odds ratio (95% confidence interval) for CKD was 1.24 (1.14–1.36) in women and 1.15 (1.05–1.26) in men with weight gain of at least 10 kg after the age of 20 years. Even in participants without metabolic syndrome, weight gain was independently associated with CKD in both genders.

Conclusions

Weight gain after 20 years of age is associated with CKD among Japanese, even those without metabolic syndrome.

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Acknowledgments

This study was supported by a Health and Labour Sciences Research Grant for “Research on the positioning of chronic kidney disease (CKD) in the Specific Health Check and Guidance System of Japan” (20230601) from the Ministry of Health, Labour and Welfare of Japan.

Conflict of interest

The authors have declared that no conflict of interest exists.

Author information

Authors and Affiliations

  1. Center for Inter-organ Communication Research, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8510, Japan

    Minako Wakasugi

  2. Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan

    Ichiei Narita

  3. Steering Committee for “Research on the Positioning of Chronic Kidney Disease (CKD) in the Specific Health Check and Guidance System of Japan”, Fukushima, Japan

    Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Hideaki Yoshida, Shoichi Fujimoto, Koichi Asahi & Tsuyoshi Watanabe

  4. Department of Biostatistics/Epidemiology and Preventive Health Sciences, School of Health Sciences and Nursing, University of Tokyo, Tokyo, Japan

    Issei Kurahashi & Yasuo Ohashi

Authors
  1. Minako Wakasugi
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  2. Ichiei Narita
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  3. Kunitoshi Iseki
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  4. Toshiki Moriyama
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  5. Kunihiro Yamagata
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  6. Kazuhiko Tsuruya
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  7. Hideaki Yoshida
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  8. Shoichi Fujimoto
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  9. Koichi Asahi
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  10. Issei Kurahashi
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  11. Yasuo Ohashi
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  12. Tsuyoshi Watanabe
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Corresponding author

Correspondence to Minako Wakasugi.

Appendix

Appendix

When the participants with a history of kidney disease were excluded, weight gain was independently associated with CKD in both genders (Tables 7 and 8).

Table 7 Multivariate analysis of the relationship between weight gain after 20 years of age and the prevalence of chronic kidney disease among women without history of kidney disease (n = 28,026)
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Table 8 Multivariate analysis of the relationship between weight gain after 20 years of age and the prevalence of chronic kidney disease among men without history of kidney disease (n = 21,027)
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Wakasugi, M., Narita, I., Iseki, K. et al. Weight gain after 20 years of age is associated with prevalence of chronic kidney disease. Clin Exp Nephrol 16, 259–268 (2012). https://doi.org/10.1007/s10157-011-0565-3

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  • DOI: https://doi.org/10.1007/s10157-011-0565-3

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