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Estimation of outer membrane permeability of carbapenem antibiotics to Pseudomonas aeruginosa

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Journal of Infection and Chemotherapy

Abstract

The outer membrane permeability of carbapenems (imipenem [IPM], panipenem [PAPM], meropenem [MEPM], and biapenem [BIPM]) and ceftazidime (CAZ) to Pseudomonas aeruginosa was determined by the Zimmermann and Rosselet method. The permeability coefficients of β-lactams tested at 50 μM concentration of substrates ranged from (0.40 ± 0.10) × 10−6 cm/s for CAZ to (2.33 ± 0.33) × 10−6 cm/s for IPM, indicating that the outer membrane permeability of carbapenems to P. aeruginosa was high in comparison with that of CAZ. In particular, IPM and BIPM showed a higher rate of penetration than MEPM and PAPM.

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Authors and Affiliations

  1. Laboratory of Drug Resistance in Bacteria, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan Tel. +81-27-220-8087; Fax +81-27-220-8088 e-mail: siyobe@akagi.sb.gunma-u.ac.jp, , , , , , JP

    S. Iyobe & M. Inoue

  2. Episome Institute, Fujimi-mura, Seta, Gunma, Japan, , , , , , JP

    Masato Watanabe & Susumu Mitsuhashi

Authors
  1. S. Iyobe
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  2. Masato Watanabe
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  3. Susumu Mitsuhashi
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  4. M. Inoue
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Additional information

Received: November 30, 1998 / Accepted: March 10, 1999

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Iyobe, S., Watanabe, M., Mitsuhashi, S. et al. Estimation of outer membrane permeability of carbapenem antibiotics to Pseudomonas aeruginosa . J Infect Chemother 5, 168–170 (1999). https://doi.org/10.1007/s101560050028

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  • DOI: https://doi.org/10.1007/s101560050028

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