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Incidence of bacterial coinfection with respiratory syncytial virus bronchopulmonary infection in pediatric inpatients

  • Original Article
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Journal of Infection and Chemotherapy

Abstract

Bacterial coinfection occurs in pediatric bronchopulmonary infections caused by respiratory syncytial virus (RSV), but the incidence is uncertain. Our subjects are 188 pediatric inpatients having RSV bronchopulmonary infection in two hospitals in Chiba Prefecture between 2005 and 2007. On admission, antigen detection kits using nasopharyngeal aspirate were performed to detect RSV infection and washed sputum bacterial culture was performed to detect bacterial infection. Of the 188 pediatric inpatients with RSV bronchopulmonary infection, 95 (50.5%) patients were aged less than 1 year, 57 (30.3%) were aged 1–2 years, and 36 (19.1%) were aged 2 years or more. Thirty-six (19.1%) patients were associated with bronchial asthma attacks. Pathogenic bacteria were predominantly isolated from 43.6% of the patients. The three most frequently isolated bacteria were Haemophilus influenzae (43.9%), Streptococcus pneumoniae (36.6%), and Moraxella catarrhalis (29.3%). We found that 38.9% of H. influenzae strains were β-lactamase-nonproducing ampicillin-resistant strains. All S. pneumoniae strains were penicillin G (PcG) sensitive. However, 21.9% of S. pneumoniae strains showed PcG minimum inhibitory concentration values of 2 μg/ml. RSV bronchopulmonary infections in hospitalized children are often associated with antimicrobial-resistant bacterial infection in their lower airways. These results indicate that we should be aware of bacterial coinfections in the management of pediatric inpatients with RSV bronchopulmonary infection.

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Authors and Affiliations

  1. Department of Pediatrics, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan

    Haruka Hishiki, Naruhiko Ishiwada, Chie Fukasawa & Yoichi Kohno

  2. Division of Infectious Disease, Chiba Children’s Hospital, Chiba, Japan

    Katsuaki Abe & Tadashi Hoshino

  3. Department of Pediatrics, Chiba Municipal Aoba Hospital, Chiba, Japan

    Jiro Aizawa & Nobuyasu Ishikawa

Authors
  1. Haruka Hishiki
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  2. Naruhiko Ishiwada
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  3. Chie Fukasawa
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  4. Katsuaki Abe
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  5. Tadashi Hoshino
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  6. Jiro Aizawa
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  7. Nobuyasu Ishikawa
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  8. Yoichi Kohno
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Correspondence to Haruka Hishiki.

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Hishiki, H., Ishiwada, N., Fukasawa, C. et al. Incidence of bacterial coinfection with respiratory syncytial virus bronchopulmonary infection in pediatric inpatients. J Infect Chemother 17, 87–90 (2011). https://doi.org/10.1007/s10156-010-0097-x

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  • DOI: https://doi.org/10.1007/s10156-010-0097-x

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