Skip to main content
SpringerLink
Log in

Antimicrobial susceptibility of pathogens isolated from more than 10 000 patients with infectious respiratory diseases: a 25-year longitudinal study

  • Review Article
  • Published:
Journal of Infection and Chemotherapy

Abstract

The Study Group on Antimicrobial Susceptibility of Pathogens Isolated from Respiratory Infections was established in 1981 in Japan to elucidate trends in such susceptibilities in patients with infectious respiratory diseases; the Group has conducted nationwide research in collaboration with 21 medical institutions. Examination of more than 10 000 patients by 2005 allowed a summary of study findings. Streptococcus pneumoniae started to become resistant to penicillin G in the 1990s, and the isolation rate of penicillin-intermediate and penicillin-resistant S. pneumoniae (PISP + PRSP) reached almost 60% in 2001. The proportion of PRSP also increased, reaching 19.4%. Thereafter, the rate of PISP + PRSP decreased somewhat to the mid-30% range. Macrolide resistance was also observed; in 2005, the prevalence of strains highly susceptible to erythromycin with MICs ≦ 0.06 µg/ml had decreased to 15.5%, whereas the proportion of highly resistant strains with MICs ≧ 128 µg/ml exceeded 40%. Among Staphylococcus aureus isolates, the proportion of methicillin-resistant S. aureus (MRSA) strains began to increase rapidly in 1986 and constituted around 60% of all S. aureus strains identified in 1990 and in the following years. In 1993, the prevalence of ampicillin-resistant isolates of Haemophilus influenzae had increased remarkably, presumably related to the outbreak of β-lactamase-negative ampicillin-resistant (BLNAR) H. influenzae strains, and the proportion of these strains among the isolates surpassed 30% in 2002 and thereafter. For Klebsiella pneumoniae, the antimicrobial activity of first- to fourth-generation cephems improved with each generation. The MIC distribution patterns of Pseudomonas aeruginosa shifted towards higher MICs when compared with the MICs for other pathogens. Broad patterns with no distinct peaks reflected the difficulty in treating P. aeruginosa infection. Regarding Moraxella catarrhalis, β-lactamase-producing strains already constituted a majority of the isolates in 1990, and the proportion of strains highly susceptible to ampicillin, with MICs ≦ 0.06 µg/ml, was less than 10% at that time.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Annual statistical report of national health conditions. Tokyo: Health and Welfare Statistics Association; 2005. p. 370–371, 414–7.

  2. Ikemoto H, Watanabe K, Kosakai N, Igari J, Oguri T, Saito A, et al. Susceptibility of bacteria isolated from lower respiratory tract infections to antibiotics (1981). Jpn J Antibiot 1983;36:2925–2950.

    CAS  PubMed  Google Scholar 

  3. Ikemoto H, Watanabe K, Kosakai N, Igarai J, Oguri T, Saito A, et al. Susceptibility of bacteria isolated from lower respiratory tract infections to antibiotics (1982). Jpn J Antibiot 1984;37:1241–1262.

    CAS  PubMed  Google Scholar 

  4. Ikemoto H, Watanabe K, Kosakai N, Hayashi Y, Oguri T, Saito A, et al. Susceptibility of bacteria isolated from lower respiratory tract infections to antibiotics (1983). Jpn J Antibiot 1985;38:3119–3144.

    CAS  PubMed  Google Scholar 

  5. Ikemoto H, Watanabe K, Kosakai N, Hayashi Y, Oguri T, Saito A, et al. Susceptibility of bacteria isolated from the patients with lower respiratory tract infections to antibiotics (1984). Jpn J Antibiot 1987;40:91–116.

    CAS  PubMed  Google Scholar 

  6. Ikemoto H, Watanabe K, Kosakai N, Hayashi Y, Oguri T, Saito A, et al. Susceptibility of bacteria isolated from the patients with lower respiratory tract infections to antibiotics (1985). Jpn J Antibiot 1987;40:1669–1697.

    CAS  PubMed  Google Scholar 

  7. Ikemoto H, Watanabe K, Kosakai N, Hayashi Y, Oguri T, Kondou T, et al. Susceptibility of bacteria isolated from the patients with lower respiratory tract infections to antibiotics (1986). Jpn J Antibiot 1989;42:2324–2353.

    CAS  PubMed  Google Scholar 

  8. Ikemoto H, Watanabe K, Kosakai N, Hayashi Y, Oguri T, Kondou T, et al. Susceptibility of bacteria isolated from the patients with lower respiratory tract infections to antibiotics (1987). Jpn J Antibiot 1990;43:147–180.

    CAS  PubMed  Google Scholar 

  9. Ikemoto H, Watanabe K, Mori T, Hayashi Y, Oguri T, Kondou T, et al. Susceptibilities of bacteria isolated from patients with respiratory infectious diseases to antibiotics (1988). Jpn J Antibiot 1991;44:770–798.

    CAS  PubMed  Google Scholar 

  10. Ikemoto H, Watanabe K, Mori T, Igari J, Oguri T, Kondou T, et al. Susceptibilities of bacteria isolated from patients with respiratory infectious diseases to antibiotics (1990). Jpn J Antibiot 1995;48:887–920.

    CAS  PubMed  Google Scholar 

  11. Ikemoto H, Watanabe K, Mori T, Igari J, Oguri T, Kondou T, et al. Susceptibilities of bacteria isolated from patients with respiratory infectious diseases to antibiotics (1991). Jpn J Antibiot 1995;48:965–998.

    CAS  PubMed  Google Scholar 

  12. Ikemoto H, Watanabe K, Mori T, Igari J, Oguri T, Kobayashi K, et al. Susceptibilities of bacteria isolated from patients with respiratory infectious diseases to antibiotics (1992). Jpn J Antibiot 1996;49:34–70.

    CAS  PubMed  Google Scholar 

  13. Ikemoto H, Watanabe K, Mori T, Igari J, Oguri T, Kobayashi K, et al. Susceptibilities of bacteria isolated from patients with respiratory infectious diseases to antibiotics (1993). Jpn J Antibiot 1996;49:107–143.

    CAS  PubMed  Google Scholar 

  14. Ikemoto H, Watanabe K, Mori T, Igari J, Oguri T, Kobayashi K, et al. Susceptibilities of bacteria isolated from patients with respiratory infectious diseases to antibiotics (1994). Jpn J Antibiot 1996;49:419–455.

    CAS  PubMed  Google Scholar 

  15. Ikemoto H, Watanabe K, Mori T, Igari J, Oguri T, Kawaguchi H, et al. Susceptibilities of bacteria isolated from patients with respiratory infectious diseases to antibiotics (1995). Jpn J Antibiot 1997;50:421–459.

    CAS  PubMed  Google Scholar 

  16. Ikemoto H, Watanabe K, Mori T, Igari J, Oguri T, Shimizu Y, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1996). Jpn J Antibiot 1998;51:437–474.

    CAS  PubMed  Google Scholar 

  17. Ikemoto H, Ito C, Yoshida T, Watanabe K, Mori T, Ohno I, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1997). Jpn J Antibiot 1999;52:353–397.

    CAS  PubMed  Google Scholar 

  18. Ikemoto H, Arakawa M, Gejyo F, Igarashi K, Mori T, Okada M, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1998). Jpn J Antibiot 2000;53:261–298.

    CAS  PubMed  Google Scholar 

  19. Shimada K, Nakano K, Ohno I, Okada S, Hayashi K, Yokouchi H, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1999). Jpn J Antibiot 2001;54:331–364.

    CAS  PubMed  Google Scholar 

  20. Shimada K, Terai T, Igari J, Inoue H, Nakadate T, Oguri T, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2000). Jpn J Antibiot 2002;55:537–567.

    PubMed  Google Scholar 

  21. Shimada K, Oguri T, Igari J, Ikemoto H, Mori T, Kitamura N, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2001). Jpn J Antibiot 2003;56:365–395.

    PubMed  Google Scholar 

  22. Shimada K, Nakano K, Igari J, Oguri T, Ikemoto H, Mori T, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2002). Jpn J Antibiot 2004;57:213–245.

    PubMed  Google Scholar 

  23. Goto H, Takeda H, Kawai S, Nakadate T, Shimada K, Nakano K, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2003). Jpn J Antibiot 2005;58:326–358.

    PubMed  Google Scholar 

  24. Goto H, Takeda H, Kawai S, Watanabe T, Okazaki M, Shimada K, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2004). Jpn J Antibiot 2006;59:323–354.

    PubMed  Google Scholar 

  25. Goto H, Takeda H, Kawai S, Watanabe S, Okazaki M, Shimada K, et al. Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2005). Jpn J Antibiot 2008;61:209–240.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Respiratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan

    Hajime Goto

  2. Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Kaoru Shimada

  3. Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

    Hideo Ikemoto

  4. Laboratory Medicine, Kameda Medical Center, Tokyo, Japan

    Toyoko Oguri

Authors
  1. Hajime Goto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kaoru Shimada
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hideo Ikemoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Toyoko Oguri
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

the Study Group on Antimicrobial Susceptibility of Pathogens Isolated from Respiratory Infections

Corresponding author

Correspondence to Hajime Goto.

About this article

Cite this article

Goto, H., Shimada, K., Ikemoto, H. et al. Antimicrobial susceptibility of pathogens isolated from more than 10 000 patients with infectious respiratory diseases: a 25-year longitudinal study. J Infect Chemother 15, 347–360 (2009). https://doi.org/10.1007/s10156-009-0719-3

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10156-009-0719-3

Key words

Search

Navigation