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A review of chronic anal fissure management

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Abstract

Anal fissure management has rapidly progressed in the last 15 years as our understanding of fissure pathophysiology has developed. All methods of treatment aim to reduce the anal sphincter spasm associated with chronic anal fissures. Surgical techniques have been used for over 100 years with success. Lateral internal sphincterotomy remains the surgical treatment of choice for many practitioners. Postoperative impairment of continence remains controversial. Recently, less invasive methods of treatment have been explored. Topical nitrates, calcium channel blockers and botulinum toxin are established treatments. These and other non-surgical treatments are described in this review. Various guidelines and treatment algorithms for anal fissure are also discussed.

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References

  1. Sailer M, Bussen D, Debus ES, Fuchs KH, Thiede A (1998) Quality of life in patients with benign anorectal disorders. Br J Surg 85:1716–1719

    PubMed  CAS  Google Scholar 

  2. Griffin N, Acheson AG, Tung P, Sheard C, Glazebrook C, Scholefield JH (2004) Quality of life in patients with chronic anal fissure. Colorectal Dis 6:39–44

    PubMed  CAS  Google Scholar 

  3. — (2003) American Gastroenterological Association medical position statement: diagnosis and care of patients with anal fissure. Gastroenterology 124:233–234

  4. Lindsey I, Jones OM, Cunningham C, Mortensen NJ (2004) Chronic anal fissure. Br J Surg 91:270–279

    PubMed  CAS  Google Scholar 

  5. Goligher JC (1984) Surgery of the anus, rectum and colon. Bailliere Tindall, London

    Google Scholar 

  6. Lund JN, Scholefield JH (1996) Aetiology and treatment of anal fissure. Br J Surg 83:1335–1344

    PubMed  CAS  Google Scholar 

  7. Hananel N, Gordon PH (1997) Re-examination of clinical manifestations and response to therapy of fissure-in-ano. Dis Colon Rectum 40:229–233

    PubMed  CAS  Google Scholar 

  8. Brodie BC (1835) Lectures on diseases of the rectum; III; Preturnatural contraction of the sphincter ani. London Medical Gazette 16:26–31

    Google Scholar 

  9. Rattan S (2005) The internal and sphincter: regulation of smooth muscle tone and relaxation. Neurogastroenterol Motil 17[Suppl 1]:50–59

    PubMed  Google Scholar 

  10. Rattan S, Regan RF, Patel CA, De Godoy MA (2005) Nitric oxide not carbon monoxide mediates nonadrenergic non-cholinergic relaxation in the murine internal anal sphincter. Gastroenterology 129:1954–1966

    PubMed  CAS  Google Scholar 

  11. Rattan S, Chakder S (1992) Role of nitric oxide as a mediator of internal anal sphincter relaxation. Am J Physiol 262:G107–G112

    PubMed  CAS  Google Scholar 

  12. Rattan S, Sarkar A, Chakder S (1992) Nitric oxide pathway in rectoanal inhibitory reflex of opossum internal anal sphincter. Gastroenterology 103:43–50

    PubMed  CAS  Google Scholar 

  13. Chakder S, Rattan S (1993) Release of nitric oxide by activation of nonadrenergic noncholinergic neurons of internal anal sphincter. Am J Physiol 264:G7–G12

    PubMed  CAS  Google Scholar 

  14. O’Kelly TJ (1996) Nerves that say NO: a new perspective on the human rectoanal inhibitory reflex. Ann R Coll Surg Engl 78:31–38

    PubMed  CAS  Google Scholar 

  15. Griffin N, Zimmerman DD, Briel JW et al (2002) Topical L-arginine gel lowers resting anal pressure: possible treatment for anal fissure. Dis Colon Rectum 45:1332–1336

    PubMed  CAS  Google Scholar 

  16. Acheson AG, Griffin N, Scholefield JH, Wilson VG (2003) L-Arginine-induced relaxation of the internal anal sphincter is not mediated by nitric oxide. Br J Surg 90:1155–1162

    PubMed  CAS  Google Scholar 

  17. Biancani P, Walsh J, Behar J (1985) Vasoactive intestinal peptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter. Gastroenterology 89:867–874

    PubMed  CAS  Google Scholar 

  18. Nurko S, Rattan S (1988) Role of vasoactive intestinal polypeptide in the internal anal sphincter relaxation of the opossum. J Clin Invest 81:1146–1153

    PubMed  CAS  Google Scholar 

  19. Rattan S, Chakder S (1997) Excitatory and inhibitory actions of pituitary adenylate cyclase-activating peptide (PACAP) in the internal anal sphincter smooth muscle: sites of actions. J Pharmacol Exp Ther 283:722–728

    PubMed  CAS  Google Scholar 

  20. Lock MR, Thomson JP (1977) Fissure-in-ano: the initial management and prognosis. Br J Surg 64:355–358

    PubMed  CAS  Google Scholar 

  21. McDonald P, Driscoll AM, Nicholls RJ (1983) The anal dilator in the conservative management of acute anal fissures. Br J Surg 70:25–26

    PubMed  CAS  Google Scholar 

  22. Lund JN (2006) Nitric oxide deficiency in the internal anal sphincter of patients with chronic anal fissure. Int J Colorectal Dis 21:673–675

    PubMed  Google Scholar 

  23. Lund JN, Scholefield JH (1997) Internal sphincter spasm in anal fissure. Br J Surg 84:1723–1724

    PubMed  CAS  Google Scholar 

  24. Mearin F, Mourelle M, Guarner F et al (1993) Patients with achalasia lack nitric oxide synthase in the gastro-oesophageal junction. Eur J Clin Invest 23:724–728

    PubMed  CAS  Google Scholar 

  25. Schouten WR, Briel JW, Auwerda JJ, De Graaf EJ (1996) Ischaemic nature of anal fissure. Br J Surg 83:63–65

    PubMed  CAS  Google Scholar 

  26. Lund JN, Binch C, McGrath J, Sparrow RA, Scholefield JH (1999) Topographical distribution of blood supply to the anal canal. Br J Surg 86:496–498

    PubMed  CAS  Google Scholar 

  27. Klosterhalfen B, Vogel P, Rixen H, Mittermayer C (1989) Topography of the inferior rectal artery: a possible cause of chronic, primary anal fissure. Dis Colon Rectum 32:43–52

    PubMed  CAS  Google Scholar 

  28. Corby H, Donnelly VS, O’Herlihy C, O’Connell PR (1997) Anal canal pressures are low in women with postpartum anal fissure. Br J Surg 84:86–88

    PubMed  CAS  Google Scholar 

  29. Favetta U, Amato A, Interisano A, Pescatori M (1996) Clinical, manometric and sonographic assessment of the anal sphincters. A comparative prospective study. Int J Colorectal Dis 11:163–166

    PubMed  CAS  Google Scholar 

  30. Bove A, Balzano A, Perrotti P, Antropoli C, Lombardi G, Pucciani F (2004) Different anal pressure profiles in patients with anal fissure. Tech Coloproctol 8:151–156

    PubMed  CAS  Google Scholar 

  31. Rosen L, Abel ME, Gordon PH et al (1992) Practice parameters for the management of anal fissure. The Standards Task Force American Society of Colon and Rectal Surgeons. Dis Colon Rectum 35:206–208

    PubMed  CAS  Google Scholar 

  32. Recamier JC (1838) Extension, massage et percussion cadancee dans le traitment des contractures musculaires. Rev Med Fr Estrang 1:74

    Google Scholar 

  33. Marby M, Alexander-Williams J, Buchmann P et al (1979) A randomized controlled trial to compare anal dilatation with lateral subcutaneous sphincterotomy for anal fissure. Dis Colon Rectum 22:308–311

    PubMed  CAS  Google Scholar 

  34. Graham-Stewart CW, Greenwood RK, Lloyd-Davies RW (1961) A review of 50 patients with fissure in ano. Surg Gynecol Obstet 113:445–448

    PubMed  CAS  Google Scholar 

  35. Fries B, Rietz KA (1964) Treatment of fissure in ano. Acta Chir Scand 128:312–315

    PubMed  CAS  Google Scholar 

  36. Watts JM, Bennett RC, Goligher JC (1964) Stretching of anal sphincters in treatment of fissure-in-ano. Br Med J 2:342–343

    PubMed  CAS  Google Scholar 

  37. Sohn N, Eisenberg MM, Weinstein MA, Lugo RN, Ader J (1992) Precise anorectal sphincter dilatation—its role in the therapy of anal fissures. Dis Colon Rectum 35:322–327

    PubMed  CAS  Google Scholar 

  38. MacDonald A, Smith A, McNeill AD, Finlay IG (1992) Manual dilatation of the anus. Br J Surg 79:1381–1382

    PubMed  CAS  Google Scholar 

  39. Isbister WH, Prasad J (1995) Fissure in ano. Aust N Z J Surg 65:107–108

    PubMed  CAS  Google Scholar 

  40. Moore KT (1975) The outpatient treatment of fissure-in-ano. Br J Clin Pract 29:181–182

    PubMed  CAS  Google Scholar 

  41. Hawley PR (1969) The treatment of chronic fissure-in-ano. A trial of methods. Br J Surg 56:915–918

    PubMed  CAS  Google Scholar 

  42. Saad AM, Omer A (1992) Surgical treatment of chronic fissure-in-ano: a prospective randomised study. East Afr Med J 69:613–615

    PubMed  CAS  Google Scholar 

  43. Weaver RM, Ambrose NS, Alexander-Williams J, Keighley MR (1987) Manual dilatation of the anus vs. lateral subcutaneous sphincterotomy in the treatment of chronic fissure-in-ano. Results of a prospective, randomized, clinical trial. Dis Colon Rectum 30:420–423

    PubMed  CAS  Google Scholar 

  44. Olsen J, Mortensen PE, Krogh Petersen I, Christiansen J (1987) Anal sphincter function after treatment of fissure-in-ano by lateral subcutaneous sphincterotomy versus anal dilatation. A randomized study. Int J Colorectal Dis 2:155–157

    PubMed  CAS  Google Scholar 

  45. Collopy B, Ryan P (1979) Comparison of lateral subcutaneous sphincterotomy with anal dilatation in the treatment of fissure in ano. Med J Aust 2:461–462, 487

    PubMed  CAS  Google Scholar 

  46. Jensen SL, Lund F, Nielsen OV, Tange G (1984) Lateral subcutaneous sphincterotomy versus anal dilatation in the treatment of fissure in ano in outpatients: a prospective randomised study. Br Med J (Clin Res Ed) 289:528–530

    Article  CAS  Google Scholar 

  47. Fischer M, Hamelmann H (1978) [Dilatation or sphincterotomy as the treatment of primary-chronic fissure in ano. Results of a random, clinical study after 2–3 years]. Chirurg 49:215–218

    PubMed  CAS  Google Scholar 

  48. Giebel GD, Horch R (1989) Treatment of anal fissure: a comparison of three different forms of therapy. Nippon Geka Hokan 58:126–133

    PubMed  CAS  Google Scholar 

  49. Oueidat D (1999) A comparative study in anal fissure treatment. J Med Liban 47:164–168

    PubMed  CAS  Google Scholar 

  50. Nelson RL (1999) Meta-analysis of operative techniques for fissure-in-ano. Dis Colon Rectum 42:1424–1428; discussion 1428–1431

    PubMed  CAS  Google Scholar 

  51. Nelson R (2005) Operative procedures for fissure in ano. Cochrane Database Syst Rev:CD002199

  52. Bekheit F (1974) Anal fissure; comparative study of various lines of treatment with 125 cases. J Egypt Med Assoc 57:365

    PubMed  CAS  Google Scholar 

  53. Speakman CT, Burnett SJ, Kamm MA, Bartram CI (1991) Sphincter injury after anal dilatation demonstrated by anal endosonography. Br J Surg 78:1429–1430

    PubMed  CAS  Google Scholar 

  54. Nielsen MB, Rasmussen OO, Pedersen JF, Christiansen J (1993) Risk of sphincter damage and anal incontinence after anal dilatation for fissure-in-ano. An endosonographic study. Dis Colon Rectum 36:677–680

    PubMed  CAS  Google Scholar 

  55. Boschetto S, Giovannone M, Tosoni M, Barberani F (2004) Hydropneumatic anal dilation in conservative treatment of chronic anal fissure: clinical outcomes and randomized comparison with topical nitroglycerin. Tech Coloproctol 8:89–92; discussion 92–83

    PubMed  CAS  Google Scholar 

  56. Lestar B, Penninckx F, Kerremans R (1987) Anal dilatation. Int J Colorectal Dis 2:167–168

    PubMed  CAS  Google Scholar 

  57. Poisson J (1977) [Anal fissure]. Can J Surg 20:417–421

    PubMed  CAS  Google Scholar 

  58. Abcarian H (1980) Surgical correction of chronic anal fissure: results of lateral internal sphincterotomy vs. fissurectomy—midline sphincterotomy. Dis Colon Rectum 23:31–36

    PubMed  CAS  Google Scholar 

  59. Notaras MJ (1971) The treatment of anal fissure by lateral subcutaneous internal sphincterotomy—a technique and results. Br J Surg 58:96–100

    PubMed  CAS  Google Scholar 

  60. Hoffmann DC, Goligher JC (1970) Lateral subcutaneous internal sphincterotomy in treatment of anal fissure. Br Med J 3:673–675

    PubMed  CAS  Google Scholar 

  61. Lewis TH, Corman ML, Prager ED, Robertson WG (1988) Long-term results of open and closed sphincterotomy for anal fissure. Dis Colon Rectum 31:368–371

    PubMed  CAS  Google Scholar 

  62. Kortbeek JB, Langevin JM, Khoo RE, Heine JA (1992) Chronic fissure-in-ano: a randomized study comparing open and subcutaneous lateral internal sphincterotomy. Dis Colon Rectum 35:835–837

    PubMed  CAS  Google Scholar 

  63. Wiley M, Day P, Rieger N, Stephens J, Moore J (2004) Open vs. closed lateral internal sphincterotomy for idiopathic fissure-in-ano: a prospective, randomized, controlled trial. Dis Colon Rectum 47:847–852

    PubMed  CAS  Google Scholar 

  64. Arroyo A, Perez F, Serrano P, Candela F, Calpena R (2004) Open versus closed lateral sphincterotomy performed as an outpatient procedure under local anesthesia for chronic anal fissure: prospective randomized study of clinical and manometric longterm results. J Am Coll Surg 199:361–367

    PubMed  Google Scholar 

  65. Garcia-Aguilar J, Belmonte C, Wong WD, Lowry AC, Madoff RD (1996) Open vs. closed sphincterotomy for chronic anal fissure: long-term results. Dis Colon Rectum 39:440–443

    PubMed  CAS  Google Scholar 

  66. Corman ML (1990) Anal fissure. In: Corman ML (ed) Colon and rectal surgery. JB Lippincott, Philadelphia, pp 115–117

    Google Scholar 

  67. Keighley MR (1993) Fissure in ano. In: Keighley MR, Williams NS (eds) Surgery of the anus, rectum and colon. WB Saunders, Philadelphia, pp 364–386

    Google Scholar 

  68. Timmcke AE, Hicks TC (1996) Fissure-in-ano. In: Zuidema GD, Condon RE (eds) Shackleford’s surgery of the alimentary tract. WB Saunders, Philadelphia, pp 322–329

    Google Scholar 

  69. Littlejohn DR, Newstead GL (1997) Tailored lateral sphincterotomy for anal fissure. Dis Colon Rectum 40: 1439–1442

    PubMed  CAS  Google Scholar 

  70. Mentes BB, Ege B, Leventoglu S, Oguz M, Karadag A (2005) Extent of lateral internal sphincterotomy: up to the dentate line or up to the fissure apex? Dis Colon Rectum 48:365–370

    PubMed  Google Scholar 

  71. Garcea G, Sutton C, Mansoori S, Lloyd T, Thomas M (2003) Results following conservative lateral sphincteromy for the treatment of chronic anal fissures. Colorectal Dis 5:311–314

    PubMed  CAS  Google Scholar 

  72. Mentes BB, Irkorucu O, Akin M, Leventoglu S, Tatlicioglu E (2003) Comparison of botulinum toxin injection and lateral internal sphincterotomy for the treatment of chronic anal fissure. Dis Colon Rectum 46:232–237

    PubMed  Google Scholar 

  73. Rudd WW (1975) Lateral subcutaneous internal sphincterotomy for chronic anal fissure, an outpatient procedure. Dis Colon Rectum 18:319–323

    PubMed  CAS  Google Scholar 

  74. Nyam DC, Pemberton JH (1999) Long-term results of lateral internal sphincterotomy for chronic anal fissure with particular reference to incidence of fecal incontinence. Dis Colon Rectum 42:1306–1310

    PubMed  CAS  Google Scholar 

  75. Zbar AP, Aslam M, Allgar V (2000) Faecal incontinence after internal sphincterotomy for anal fissure. Tech Coloproctol 4:25–28

    Google Scholar 

  76. Rotholtz NA, Bun M, Mauri MV, Bosio R, Peczan CE, Mezzadri NA (2005) Long-term assessment of fecal incontinence after lateral internal sphincterotomy. Tech Coloproctol 9:115–118

    PubMed  CAS  Google Scholar 

  77. Brown CJ, Dubreuil D, Santoro L, Liu M, O’Connor BI, McLeod RS (2007) Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: six-year follow-up of a multicenter, randomized, controlled trial. Dis Colon Rectum 50:442–448

    PubMed  Google Scholar 

  78. Casillas S, Hull TL, Zutshi M, Trzcinski R, Bast JF, Xu M (2005) Incontinence after a lateral internal sphincterotomy: are we underestimating it? Dis Colon Rectum 48:1193–1199

    PubMed  Google Scholar 

  79. Sultan AH, Kamm MA, Nicholls RJ, Bartram CI (1994) Prospective study of the extent of internal anal sphincter division during lateral sphincterotomy. Dis Colon Rectum 37:1031–1033

    PubMed  CAS  Google Scholar 

  80. Rosa G, Lolli P, Piccinelli D et al (2005) Calibrated lateral internal sphincterotomy for chronic anal fissure. Tech Coloproctol 9:127–131; discussion 131–122

    PubMed  CAS  Google Scholar 

  81. Garcia-Aguilar J, Belmonte Montes C, Perez JJ, Jensen L, Madoff RD, Wong WD (1998) Incontinence after lateral internal sphincterotomy: anatomic and functional evaluation. Dis Colon Rectum 41:423–427

    PubMed  CAS  Google Scholar 

  82. Madoff RD, Steele SR (2006) Anorectal manometry and anal fissure treatment: authors’ reply. Aliment Pharmacol Ther 24:1652

    Google Scholar 

  83. Mentes BB, Tezcaner T, Yilmaz U, Leventoglu S, Oguz M (2006) Results of lateral internal sphincterotomy for chronic anal fissure with particular reference to quality of life. Dis Colon Rectum 49:1045–1051

    PubMed  Google Scholar 

  84. Ortiz H, Marzo J, Armendariz P, De Miguel M (2005) Quality of life assessment in patients with chronic anal fissure after lateral internal sphincterotomy. Br J Surg 92:881–885

    PubMed  CAS  Google Scholar 

  85. Di Castro A, Biancari F, D’Andrea V, Caviglia A (1997) Fissurectomy with posterior midline sphincterotomy and anoplasty (FPSA) in the management of chronic anal fissures. Surg Today 27:975–978

    PubMed  Google Scholar 

  86. Engel AF, Eijsbouts QA, Balk AG (2002) Fissurectomy and isosorbide dinitrate for chronic fissure in ano not responding to conservative treatment. Br J Surg 89:79–83

    PubMed  CAS  Google Scholar 

  87. Meier zu Eissen J (2001) [Chronic anal fissure, therapy]. Kongressbd Dtsch Ges Chir Kongr 118:654–656

    PubMed  CAS  Google Scholar 

  88. Lindsey I, Cunningham C, Jones OM, Francis C, Mortensen NJ (2004) Fissurectomy-botulinum toxin: a novel sphincter-sparing procedure for medically resistant chronic anal fissure. Dis Colon Rectum 47:1947–1952

    PubMed  Google Scholar 

  89. Hsu TC, MacKeigan JM (1984) Surgical treatment of chronic anal fissure. A retrospective study of 1753 cases. Dis Colon Rectum 27:475–478

    PubMed  CAS  Google Scholar 

  90. Pelta K, Davis K, Armstrong D (2007) Subcutaneous fissurotomy: a novel sphincter-saving procedure for chronic fissure-in-ano. Dis Colon Rectum 50:738 (abstract)

    Google Scholar 

  91. Ruiz-Moreno F (1968) Sliding mucocutaneous flap for the treatment of anal ulcer. Dis Colon Rectum 11:285–288

    PubMed  CAS  Google Scholar 

  92. Leong AF, Seow-Choen F (1995) Lateral sphincterotomy compared with anal advancement flap for chronic anal fissure. Dis Colon Rectum 38:69–71

    PubMed  CAS  Google Scholar 

  93. Nyam DC, Wilson RG, Stewart KJ, Farouk R, Bartolo DC (1995) Island advancement flaps in the management of anal fissures. Br J Surg 82:326–328

    PubMed  CAS  Google Scholar 

  94. Jonas M, Scholefield JH (2001) Anal fissure. Gastroenterol Clin North Am 30:167–181

    PubMed  CAS  Google Scholar 

  95. Fung HL (1993) Clinical pharmacology of organic nitrates. Am J Cardiol 72:9C–13C; discussion 14C–15C

    PubMed  CAS  Google Scholar 

  96. Davies MG, Fulton GJ, Hagen PO (1995) Clinical biology of nitric oxide. Br J Surg 82:1598–1610

    PubMed  CAS  Google Scholar 

  97. Ahlner J, Andersson RG, Torfgard K, Axelsson KL (1991) Organic nitrate esters: clinical use and mechanisms of actions. Pharmacol Rev 43:351–423

    PubMed  CAS  Google Scholar 

  98. Feelisch M (1991) The biochemical pathways of nitric-oxide formation from nitrovasodilators — appropriate choice of exogenous NO donors and aspects of preparation and handling of aqueous NO solutions. J Cardiovasc Pharmacol 17:S25–S33

    CAS  Google Scholar 

  99. Fung HL (1992) Do nitrates differ? Br J Clin Pharmacol 34[Suppl 1]:5S–9S

    PubMed  CAS  Google Scholar 

  100. Bogaert MG (1987) Clinical pharmacokinetics of glyceryl trinitrate following the use of systemic and topical preparations. Clin Pharmacokinet 12:1–11

    PubMed  CAS  Google Scholar 

  101. Jonas M, Barrett DA, Shaw PN, Scholefield JH (2001) Systemic levels of glyceryl trinitrate following topical application to the anoderm do not correlate with the measured reduction in anal pressure. Br J Surg 88:1613–1616

    PubMed  CAS  Google Scholar 

  102. L’Hopital F, Michelland O, Lunaud B, Bommelaere G (1990) Constipation et hypertonie du sphincter interne de l’anus: response sphincterienne a l’administration sub-linguale de 0.40 mg de Natispray. Gastroenterol Clin Biol 14:268

    Google Scholar 

  103. Guillemot F, Lone YC, Leroi H, Lamblin MD, Cortot A (1992) Nitroglycerin in situ reduces upper anal canal pressure. Dig Dis Sci 37:155

    PubMed  CAS  Google Scholar 

  104. Guillemot F, Leroi H, Lone YC, Rousseau CG, Lamblin MD, Cortot A (1993) Action of in situ nitroglycerin on upper anal canal pressure of patients with terminal constipation. A pilot study. Dis Colon Rectum 36:372–376

    PubMed  CAS  Google Scholar 

  105. Lund JN, Armitage NC, Scholefield JH (1996) Use of glyceryl trinitrate ointment in the treatment of anal fissure. Br J Surg 83:776–777

    PubMed  CAS  Google Scholar 

  106. Gorfine SR (1995) Treatment of benign anal disease with topical nitroglycerin. Dis Colon Rectum 38:453–456; discussion 456–457

    PubMed  CAS  Google Scholar 

  107. Gorfine SR (1995) Topical nitroglycerin therapy for anal fissures and ulcers. N Engl J Med 333:1156–1157

    PubMed  CAS  Google Scholar 

  108. Lund JN, Scholefield JH (1997) A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 349:11–14

    PubMed  CAS  Google Scholar 

  109. Nelson R (2006) Non surgical therapy for anal fissure. Cochrane Database Syst Rev:CD003431

  110. Parellada C (2004) Randomized, prospective trial comparing 0.2 percent isosorbide dinitrate ointment with sphincterotomy in treatment of chronic anal fissure: a two-year follow-up. Dis Colon Rectum 47:437–443

    PubMed  Google Scholar 

  111. Loder PB, Kamm MA, Nicholls RJ, Phillips RK (1994) ’Reversible chemical sphincterotomy’ by local application of glyceryl trinitrate. Br J Surg 81:1386–1389

    PubMed  CAS  Google Scholar 

  112. Altomare DF, Rinaldi M, Milito G et al (2000) Glyceryl trinitrate for chronic anal fissure—healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. Dis Colon Rectum 43:174–179; discussion 179–181

    PubMed  CAS  Google Scholar 

  113. Azarnoff DL, Lee JC, Lee C, Chandler J, Karlin D (2007) Quality of extemporaneously compounded nitroglycerin ointment. Dis Colon Rectum 50:509–516

    PubMed  Google Scholar 

  114. Scholefield JH, Bock JU, Marla B et al (2003) A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures. Gut 52:264–269

    PubMed  CAS  Google Scholar 

  115. Bailey HR, Beck DE, Billingham RP et al (2002) A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. Dis Colon Rectum 45:1192–1199

    PubMed  Google Scholar 

  116. Zuberi BF, Rajput MR, Abro H, Shaikh SA (2000) A randomized trial of glyceryl trinitrate ointment and nitroglycerin patch in healing of anal fissures. Int J Colorectal Dis 15:243–245

    PubMed  CAS  Google Scholar 

  117. De Nardi P, Ortolano E, Radaelli G, Staudacher C (2006) Comparison of glycerine trinitrate and botulinum toxin-a for the treatment of chronic anal fissure: long-term results. Dis Colon Rectum 49:427–432

    PubMed  Google Scholar 

  118. Brisinda G, Maria G, Bentivoglio AR, Cassetta E, Gui D, Albanese A (1999) A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl J Med 341:65–69

    PubMed  CAS  Google Scholar 

  119. Cook TA, Humphreys MM, McCMortensen NJ (1999) Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. Br J Surg 86:1269–1273

    PubMed  CAS  Google Scholar 

  120. Fenton C, Wellington K, Easthope SE (2006) 0.4% nitroglycerin ointment: in the treatment of chronic anal fissure pain. Drugs 66:343–349

    PubMed  CAS  Google Scholar 

  121. Oettle GJ (1997) Glyceryl trinitrate vs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial. Dis Colon Rectum 40:1318–1320

    PubMed  CAS  Google Scholar 

  122. Evans J, Luck A, Hewett P (2001) Glyceryl trinitrate vs. lateral sphincterotomy for chronic anal fissure: prospective, randomized trial. Dis Colon Rectum 44:93–97

    PubMed  CAS  Google Scholar 

  123. Richard CS, Gregoire R, Plewes EA et al (2000) Internal sphincterotomy is superior to topical nitroglycerin in the treatment of chronic anal fissure: results of a randomized, controlled trial by the Canadian Colorectal Surgical Trials Group. Dis Colon Rectum 43:1048–1057; discussion 1057–1048

    PubMed  CAS  Google Scholar 

  124. Libertiny G, Knight JS, Farouk R (2002) Randomised trial of topical 0.2% glyceryl trinitrate and lateral internal sphincterotomy for the treatment of patients with chronic anal fissure: long-term follow-up. Eur J Surg 168:418–421

    PubMed  Google Scholar 

  125. Mishra R, Thomas S, Maan MS, Hadke NS (2005) Topical nitroglycerin versus lateral internal sphincterotomy for chronic anal fissure: prospective, randomized trial. ANZ J Surg 75:1032–1035

    PubMed  Google Scholar 

  126. Graziano A, Svidler Lopez L, Lencinas S, Masciangioli G, Gualdrini U, Bisisio O (2001) Long-term results of topical nitroglycerin in the treatment of chronic anal fissures are dis-appointing. Tech Coloproctol 5:143–147

    PubMed  CAS  Google Scholar 

  127. Chrysos E, Xynos E, Tzovaras G, Zoras OJ, Tsiaoussis J, Vassilakis SJ (1996) Effect of nifedipine on rectoanal motility. Dis Colon Rectum 39:212–216

    PubMed  CAS  Google Scholar 

  128. Cook TA, Brading AF, Mortensen NJ (1999) Effects of nifedipine on anorectal smooth muscle in vitro. Dis Colon Rectum 42:782–787

    PubMed  CAS  Google Scholar 

  129. Antropoli C, Perrotti P, Rubino M et al (1999) Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicenter study. Dis Colon Rectum 42:1011–1015

    PubMed  CAS  Google Scholar 

  130. Carapeti EA, Kamm MA, Phillips RK (2000) Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects. Dis Colon Rectum 43:1359–1362

    PubMed  CAS  Google Scholar 

  131. Knight JS, Birks M, Farouk R (2001) Topical diltiazem ointment in the treatment of chronic anal fissure. Br J Surg 88:553–556

    PubMed  CAS  Google Scholar 

  132. Griffin N, Acheson AG, Jonas M, Scholefield JH (2002) The role of topical diltiazem in the treatment of chronic anal fissures that have failed glyceryl trinitrate therapy. Colorectal Dis 4:430–435

    PubMed  CAS  Google Scholar 

  133. Jonas M, Speake W, Scholefield JH (2002) Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study. Dis Colon Rectum 45:1091–1095

    PubMed  Google Scholar 

  134. DasGupta R, Franklin I, Pitt J, Dawson PM (2002) Successful treatment of chronic anal fissure with diltiazem gel. Colorectal Dis 4:20–22

    PubMed  Google Scholar 

  135. Mustafa NA, Cengiz S, Turkyilmaz S, Yucel Y (2006) Comparison of topical glyceryl trinitrate ointment and oral nifedipine in the treatment of chronic anal fissure. Acta Chir Belg 106:55–58

    PubMed  CAS  Google Scholar 

  136. Ansaloni L, Bernabe A, Ghetti R, Riccardi R, Tranchino RM, Gardini G (2002) Oral lacidipine in the treatment of anal fissure. Tech Coloproctol 6:79–82

    PubMed  CAS  Google Scholar 

  137. Agaoglu N, Cengiz S, Arslan MK, Turkyilmaz S (2003) Oral nifedipine in the treatment of chronic anal fissure. Dig Surg 20:452–456

    PubMed  CAS  Google Scholar 

  138. Ho KS, Ho YH (2005) Randomized clinical trial comparing oral nifedipine with lateral anal sphincterotomy and tailored sphincterotomy in the treatment of chronic anal fissure. Br J Surg 92:403–408

    PubMed  Google Scholar 

  139. Montecucco C, Molgo J (2005) Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol 5:274–279

    PubMed  CAS  Google Scholar 

  140. Dolly JO, Aoki KR (2006) The structure and mode of action of different botulinum toxins. Eur J Neurol 13[Suppl 4]:1–9

    PubMed  Google Scholar 

  141. Runfola M, Di Mugno M, Balletta A, Magalini SC, Gui D (2006) Antinociceptive effect of botulinum toxin: an added value to chemical sphincterotomy in anal fissure? Dis Colon Rectum 49:1078–1079

    PubMed  Google Scholar 

  142. Jones OM, Brading AF, Mortensen NJ (2004) Mechanism of action of botulinum toxin on the internal anal sphincter. Br J Surg 91:224–228

    PubMed  CAS  Google Scholar 

  143. Jost WH, Schimrigk K (1993) Use of botulinum toxin in anal fissure. Dis Colon Rectum 36:974

    PubMed  CAS  Google Scholar 

  144. Maria G, Cassetta E, Gui D, Brisinda G, Bentivoglio AR, Albanese A (1998) A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 338:217–220

    PubMed  CAS  Google Scholar 

  145. Fruehauf H, Fried M, Wegmueller B, Bauerfeind P, Thumshirn M (2006) Efficacy and safety of botulinum toxin a injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: a prospective randomized study. Am J Gastroenterol 101:2107–2112

    PubMed  CAS  Google Scholar 

  146. Lysy J, Israelit-Yatzkan Y, Sestiery-Ittah M, Weksler-Zangen S, Keret D, Goldin E (2001) Topical nitrates potentiate the effect of botulinum toxin in the treatment of patients with refractory anal fissure. Gut 48:221–224

    PubMed  CAS  Google Scholar 

  147. Jost WH (1997) One hundred cases of anal fissure treated with botulin toxin: early and long-term results. Dis Colon Rectum 40:1029–1032

    PubMed  CAS  Google Scholar 

  148. Arroyo A, Perez F, Serrano P, Candela F, Lacueva J, Calpena R (2005) Surgical versus chemical (botulinum toxin) sphincterotomy for chronic anal fissure: long-term results of a prospective randomized clinical and manometric study. Am J Surg 189:429–434

    PubMed  CAS  Google Scholar 

  149. Minguez M, Herreros B, Espi A et al (2002) Long-term follow-up (42 months) of chronic anal fissure after healing with botulinum toxin. Gastroenterology 123:112–117

    PubMed  Google Scholar 

  150. Massoud BW, Mehrdad V, Baharak T, Alireza Z (2005) Botulinum toxin injection versus internal anal sphincterotomy for the treatment of chronic anal fissure. Ann Saudi Med 25:140–142

    PubMed  Google Scholar 

  151. Iswariah H, Stephens J, Rieger N, Rodda D, Hewett P (2005) Randomized prospective controlled trial of lateral internal sphincterotomy versus injection of botulinum toxin for the treatment of idiopathic fissure in ano. ANZ J Surg 75:553–555

    PubMed  Google Scholar 

  152. Garrido R, Lagos N, Lattes K et al (2005) Gonyautoxin: new treatment for healing acute and chronic anal fissures. Dis Colon Rectum 48:335–340; discussion 340–333

    PubMed  Google Scholar 

  153. Gui D, Cassetta E, Anastasio G, Bentivoglio AR, Maria G, Albanese A (1994) Botulinum toxin for chronic anal fissure. Lancet 344:1127–1128

    PubMed  CAS  Google Scholar 

  154. Jost WH, Schrank B (1999) Repeat botulin toxin injections in anal fissure: in patients with relapse and after insufficient effect of first treatment. Dig Dis Sci 44:1588–1589

    PubMed  CAS  Google Scholar 

  155. Gonzalez Carro P, Perez Roldan F, Legaz Huidobro ML, Ruiz Carrillo F, Pedraza Martin C, Saez Bravo JM (1999) [The treatment of anal fissure with botulinum toxin]. Gastroenterol Hepatol 22:163–166

    PubMed  CAS  Google Scholar 

  156. Fernandez Lopez F, Conde Freire R, Rios Rios A, Garcia Iglesias J, Cainzos Fernandez M, Potel Lesquereux J (1999) Botulinum toxin for the treatment of anal fissure. Dig Surg 16:515–518

    PubMed  CAS  Google Scholar 

  157. Minguez M, Melo F, Espi A et al (1999) Therapeutic effects of different doses of botulinum toxin in chronic anal fissure. Dis Colon Rectum 42:1016–1021

    PubMed  CAS  Google Scholar 

  158. Brown SR, Matabudul Y, Shorthouse AJ (2006) A second case of long-term incontinence following Botulinum toxin injection for anal fissure. Colorectal Dis 8:452–453

    PubMed  CAS  Google Scholar 

  159. Smith M, Frizelle F (2004) Long-term faecal incontinence following the use of botulinum toxin. Colorectal Dis 6:526–527

    PubMed  CAS  Google Scholar 

  160. Gosselink MP, Darby M, Zimmerman DD, Gruss HJ, Schouten WR (2005) Treatment of chronic anal fissure by application of L-arginine gel: a phase II study in 15 patients. Dis Colon Rectum 48:832–837

    PubMed  CAS  Google Scholar 

  161. Prins HA, Gosselink MP, Mitales LE et al (2005) The effect of oral administration of L-arginine on anal resting pressure and anodermal blood flow in healthy volunteers. Tech Coloproctol 9:229–232; discussion 232–223

    PubMed  CAS  Google Scholar 

  162. Muthukumarassamy R, Robinson SS, Sarath SC, Raveendran R (2005) Treatment of anal fissures using a combination of minoxidil and lignocaine: a randomized, double-blind trial. Indian J Gastroenterol 24:158–160

    PubMed  Google Scholar 

  163. Al-Hilli Z, Pritchard R, Roche-Nagle G, Deasy J, McNamara DA (2006) Nicorandil related anal ulcer. Ir J Med Sci 175:62–63

    Article  PubMed  CAS  Google Scholar 

  164. Rival AL, Allombert-Blaise C, Ly A, Grandjean JP, Faure M, Claudy A (2006) [Nicorandil-associated anal ulceration]. Ann Dermatol Venereol 133:781–783

    PubMed  Google Scholar 

  165. Watson A, Al-Ozairi O, Fraser A, Loudon M, O’Kelly T (2002) Nicorandil associated anal ulceration. Lancet 360:546–547

    PubMed  CAS  Google Scholar 

  166. Toquero L, Briggs CD, Bassuini MM, Rochester JR (2006) Anal ulceration associated with nicorandil: case series and review of the literature. Colorectal Dis 8:717–720

    PubMed  CAS  Google Scholar 

  167. Yamato S, Rattan S (1990) Role of alpha adrenoceptors in opossum internal anal sphincter. J Clin Invest 86:424–429

    Article  PubMed  CAS  Google Scholar 

  168. Pitt J, Craggs MM, Henry MM, Boulos PB (2000) Alpha-1 adrenoceptor blockade: potential new treatment for anal fissures. Dis Colon Rectum 43:800–803

    PubMed  CAS  Google Scholar 

  169. Pitt J, Dawson PM, Hallan RI, Boulos PB (2001) A double-blind randomized placebo-controlled trial of oral indoramin to treat chronic anal fissure. Colorectal Dis 3:165–168

    PubMed  CAS  Google Scholar 

  170. Boolell M, Allen MJ, Ballard SA et al (1996) Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 8:47–52

    PubMed  CAS  Google Scholar 

  171. Ito T, Ozawa K, Shimada K (2007) Current drug targets and future therapy of pulmonary arterial hypertension. Curr Med Chem 14:719

    PubMed  CAS  Google Scholar 

  172. Lichtenstein JR (2003) Use of sildenafil citrate in Raynaud’s phenomenon: comment on the article by Thompson et al. Arthritis Rheum 48:282–283; author reply 283

    PubMed  Google Scholar 

  173. Heymann WR (2006) Sildenafil for the treatment of Raynaud’s phenomenon. J Am Acad Dermatol 55:501–502

    PubMed  Google Scholar 

  174. Khan RN, Hamoud H, Warren A, Wong LF, Arulkumaran S (2004) Relaxant action of sildenafil citrate (Viagra) on human myometrium of pregnancy. Am J Obstet Gynecol 191:315–321

    PubMed  CAS  Google Scholar 

  175. Torrabadella L, Salgado G, Burns RW, Berman IR (2004) Manometric study of topical sildenafil (Viagra) in patients with chronic anal fissure: sildenafil reduces anal resting tone. Dis Colon Rectum 47:733–738

    PubMed  Google Scholar 

  176. Aygen E, Camci C, Durmus AS et al (2005) Inhibitory effects of sildenafil citrate on the tonus of isolated dog internal anal sphincter. Dis Colon Rectum 48:1615–1619

    PubMed  Google Scholar 

  177. Ballester C, Sarria B, Garcia-Granero E, Morcillo EJ, Lledo S, Cortijo J (2007) Relaxation of the isolated human internal anal sphincter by sildenafil. Br J Surg 94:894–902

    PubMed  CAS  Google Scholar 

  178. De Godoy MA, Dunn S, Rattan S (2004) Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone. Gastroenterology 127:127–138

    PubMed  Google Scholar 

  179. De Godoy MA, Rattan S (2005) Autocrine regulation of internal anal sphincter tone by renin-angiotensin system: comparison with phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol 289:G1164–G1175

    PubMed  Google Scholar 

  180. Khaikin (2007) Topical captopril cream: a new treatment for anal fissure? The first human study. Dis Colon Rectum 50:747 (abstract)

    Google Scholar 

  181. Madoff RD, Fleshman JW (2003) AGA technical review on the diagnosis and care of patients with anal fissure. Gastroenterology 124:235–245

    PubMed  Google Scholar 

  182. Orsay C, Rakinic J, Perry WB et al (2004) Practice parameters for the management of anal fissures (revised). Dis Colon Rectum 47:2003–2007

    PubMed  Google Scholar 

  183. CKS (2005) Anal Fissure (PRODIGY guidance). Clinical Knowledge Summaries Service. www.cks.library.nhs.uk/anal_fissure [Accessed: June 2007]

  184. Lund JN, Nystrom PO, Coremans G et al (2006) An evidence-based treatment algorithm for anal fissure. Tech Coloproctol 10:177–180

    PubMed  CAS  Google Scholar 

  185. Chronic anal fissure hospital episode statistics, Department of Health. (available at http://www.hesonline.nhs.uk/Ease/servlet/ContentServer?siteID=1937&categoryID=192)

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Collins, E.E., Lund, J.N. A review of chronic anal fissure management. Tech Coloproctol 11, 209–223 (2007). https://doi.org/10.1007/s10151-007-0355-9

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