Abstract
Background
To explore arterial stiffness during the administration of androgen deprivation therapy (ADT) in patients with prostate cancer (PCa), a new indicator, the cardio-ankle vascular index (CAVI), and serum lipid profile changes were monitored.
Methods
A prospective study assessed the changes in arterial stiffness using the CAVI and clinical laboratory variables among 58 men with prostate cancer treated with ADT for 6 months. Furthermore, patients who had a high risk of developing arterial stiffness after ADT were investigated.
Results
The whole cohort had no significant increase in arterial stiffness within 6 months after ADT, but 55.2 % of patients had an increased CAVI. Serum levels of total cholesterol, high-density-lipoprotein cholesterol (HDL-C), and low-density-lipoprotein cholesterol (LDL-C) increased significantly at 1 month after the start of ADT and maintained high values thereafter. At baseline, HDL-C was lower and LDL-C and LDL-C/HDL-C were higher in the group with than without an increased CAVI after 6 months of ADT administration.
Conclusions
Although the whole cohort did not show a significant change in arterial stiffness with ADT, some patients showed an increased arterial stiffness monitored with the CAVI. The balance between LDL-C and HDL-C, or LDL-C/HDL-C, might have an impact on the development of arterial stiffness after ADT administration. Thus, clinicians might be able to monitor PCa patients who have a high risk of development of arterial stiffness after ADT administration by referring to LDL-C/HDL-C levels.
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Conflict of interest
Hiroyoshi Suzuki has received honoraria and/or research grants from Astellas Pharma Inc., GlaxoSmithKline K., Takeda Pharmaceutical Company Ltd., Astra Zeneca, Novartis Pharma, Daiichi-Sankyo, Sanofi KK., and Janssen.
The following authors have no conflict of interest: Ryo Oka, Takanobu Utsumi, Takumi Endo, Masashi Yano, Shuichi Kamijima, Naoto Kamiya, and Kohji Shirai.
Funding statement
This work was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, Sports and Culture of Japan (No. 25462503) to Hiroyoshi Suzuki.
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Oka, R., Utsumi, T., Endo, T. et al. Effect of androgen deprivation therapy on arterial stiffness and serum lipid profile changes in patients with prostate cancer: a prospective study of initial 6-month follow-up. Int J Clin Oncol 21, 389–396 (2016). https://doi.org/10.1007/s10147-015-0891-7
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DOI: https://doi.org/10.1007/s10147-015-0891-7