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Postoperative adjuvant therapy for completely resected early-stage non-small cell lung cancer

  • FROM THE ASCO-JSCO JOINT SYMPOSIUM
  • Published:
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Abstract

Consensus on adjuvant therapy for completely resected non-small cell lung cancer until 2002 was as follows. (1) There was no significant impact of postoperative adjuvant chemotherapy based on meta-analysis and previous clinical trials. (2) Confirmatory studies are necessary in large-scale prospective clinical trials. However, recent mega trials have introduced epoch-making changes for postoperative adjuvant chemotherapy in clinical practice since ASCO 2003. The effectiveness of UFT in N0 patients was confirmed. Patients with completely resected stage I non-small cell lung cancer, especially T2N0 adenocarcinoma, will benefit from adjuvant chemotherapy with UFT. The results of the International Adjuvant Lung Trial (IALT) have confirmed the meta-analysis in 1995. Also, both the JBR10 and Cancer and Leukemia Group B (CALGB) 9633 studies have also confirmed positive IALT results of the benefit for postoperative platinum-based chemotherapy in completely resected non-small cell lung cancer. Adjuvant chemotherapy for pathological stage IB to II, completely resected non-small cell lung cancer is standard care based on clinical trials. UFT showed the strongest evidence for IB in Japan. Platinum doublet chemotherapy with third-generation anticancer agents is also recommended. Adjuvant chemotherapy should be offered as standard care to patients after completely resected early stage non-small cell lung cancer. However, there is no evidence of the feasibility and efficacy for adjuvant chemotherapy with the platinum-based regimen in Japan. Careful management should be necessary in such treatment.

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Authors and Affiliations

  1. Department of Surgery, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Harubumi Kato, Masahiro Tsuboi & Yasufumi Kato

  2. Department of Thoracic Surgery, International University of Health and Welfare, Tokyo, Japan

    Norihiko Ikeda & Tetsuya Okunaka

  3. Faculty of Engineering, Tokyo University of Science, Tokyo, Japan

    Chikuma Hamada

Authors
  1. Harubumi Kato
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  2. Masahiro Tsuboi
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  3. Yasufumi Kato
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  4. Norihiko Ikeda
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  5. Tetsuya Okunaka
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  6. Chikuma Hamada
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Corresponding author

Correspondence to Masahiro Tsuboi.

Additional information

The ASCO-JSCO Joint Symposium was held in Kyoto, Japan, on October 29, 2004.

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Kato, H., Tsuboi, M., Kato, Y. et al. Postoperative adjuvant therapy for completely resected early-stage non-small cell lung cancer. Int J Clin Oncol 10, 157–164 (2005). https://doi.org/10.1007/s10147-005-0493-x

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  • DOI: https://doi.org/10.1007/s10147-005-0493-x

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