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Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy

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Abstract

We report a patient with gastric small cell carcinoma (SCC) who showed a marked response to neoadjuvant chemotherapy. The patient was a 72-year-old Japanese man who was admitted because of epigastralgia. Subsequent examination revealed the presence of advanced gastric carcinoma in the lesser curvature of the lower body of the stomach, with multiple abdominal lymph node metastases. Endoscopic biopsy specimens from the tumor revealed SCC with moderately differentiated adenocarcinoma. The patient received neoadjuvant chemotherapy consisting of carboplatin (400 mg/m2, for 1 day), epirubicin (27 mg/m2, for 1 day), etoposide (70 mg/m2, for 3 days), and 5-fluorouracil (330 mg/m2, for 11 days). Clinically, the primary tumor and lymph node metastases were markedly reduced. Subsequently the patient underwent curative surgery and was alive without recurrence for more than 3 years after the surgery.

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Authors and Affiliations

  1. Department of Pathology, Tohoku Graduate University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Yasuhiro Nakamura, Toshie Suzuki & Hironobu Sasano

  2. Division of Gastroenterology, Akita City Hospital, Akita, Japan

    Setsuya Otani & Masahumi Komatsu

  3. First Department of Internal Medicine, Akita University School of Medicine, Akita, Japan

    Michiro Otaka

  4. Department of Surgery, Hiraka General Hospital, Akita, Japan

    Tomoyuki Shimada

  5. Department of Pathology, Hiraka General Hospital, Akita, Japan

    Satsuki Takahashi & Masahiro Saito

  6. Second Department of Internal Medicine, Hiraka General Hospital, Akita, Japan

    Tohru Takahashi & Masato Hayashi

  7. First Department of Internal Medicine, Hiraka General Hospital, Akita, Japan

    Shunji Okubo

Authors
  1. Yasuhiro Nakamura
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  2. Setsuya Otani
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  3. Michiro Otaka
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  4. Tomoyuki Shimada
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  5. Satsuki Takahashi
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  9. Toshie Suzuki
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  12. Hironobu Sasano
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Corresponding author

Correspondence to Yasuhiro Nakamura.

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Nakamura, Y., Otani, S., Otaka, M. et al. Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy. Int J Clin Oncol 10, 348–352 (2005). https://doi.org/10.1007/s10147-005-0492-y

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  • DOI: https://doi.org/10.1007/s10147-005-0492-y

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