Gastric enterochromaffin-like-cell tumor with liver and splenic metastases

Abstract:

We report a patient with gastric enterochromaffin-like-cell tumor with liver and splenic metastases. He was 68 years old and presented with major complaints of epigastric pain and weight loss. Under the diagnosis of gastric carcinoma with liver metastasis, total gastrectomy with splenectomy and lateral seg-mentectomy of the liver was performed. Intraoperative findings resulted in a diagnosis of adenocarcinoma T₃N₂P₀H₁, in stage IVa. Histological examination of the resected specimens showed a well differentiated neuroendocrine carcinoma (enterochromaffin-like-cell tumor) with liver and splenic metastasis which demonstrated high-grade lymphatic and vascular invasion. There was no lymph node metastasis. The tumor cells in the stomach, liver and spleen were immunoreactive for chromogranin A and Grimelius—positive. We review the literature, as well as presenting this case report.