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The 100 most-cited articles on vestibular schwannoma: historical perspectives, current limitations, and future research directions

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Abstract

There has been a steady increase of vestibular schwannoma (VS) research in the body of literature. To delineate the most impactful works on VS, a bibliometric analysis is warranted. The Thomson Reuters Web of Sciences database was queried to identify all articles on VS published to June 2020. The articles were sorted in descending order of the number of citations. Titles and abstracts of the top 100 most-cited articles were screened to identify the research area, publication year, author, and country of publication. Our query yielded 6477 research publications. The 100 most-cited articles were cited 15804 times. The most productive decade was the 1990s (40% of the top 100 articles). Twenty-five journals contributed to all included articles. Journal of Neurosurgery contributed most of the articles (20%). Most common contributing country was the USA (60%). “Operative treatment” was the most common research topic (68%), followed by other aspects such as medical management (13%), epidemiology (12%), diagnosis (5%), or translational medicine (2%). The current analysis highlights the importance of the multimodal approach in the study and treatment of VS. While emphasizing the relevance of including highly cited articles in the current education of VS, our results point out the deficiency in certain research areas with high impact in other fields of neuro-oncology, such as translational medicine and molecular epigenetics.

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Authors and Affiliations

  1. Departments of Neurosurgery, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA

    Rafael Martinez-Perez, Timothy H. Ung & A. Samy Youssef

  2. Department of Neurosurgery, University of Colorado School of Medicine, 1635 Aurora Ct, 4th floor, Aurora, CO, 80045, USA

    Rafael Martinez-Perez & A. Samy Youssef

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  3. A. Samy Youssef
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Contributions

Conception and design of study: Rafael Martinez-Perez. Acquisition of data: Rafael Martinez-Perez, Timothy Ung. Analysis and/or interpretation of data: Rafael Martinez-Perez, Timothy Ung. Drafting the manuscript: Rafael Martinez-Perez. Revising the manuscript critically for important intellectual content: Timothy Ung, Samy Youssef. Approval of the version of the manuscript to be published: all authors.

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Correspondence to Rafael Martinez-Perez or A. Samy Youssef.

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Informed consent and ethical approval were not deemed necessary by the local ethics in view of the design of the study (review).

Conflict of interest

A. Samy Youssef is a consultant for Stryker Corp and has received royalties from Mizuho America.

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In brief

We performed a bibliographic analysis of the existent literature on vestibular schwannoma. We sought to provide clinicians and researchers with an updated understanding of the evolving landscape in the clinical and research practices of VS. Our results should not only serve an updated reference for researchers but it should also elicit the current limitations in VS research. Unlike other neurooncological diseases, basic research is still marginal among the most relevant studies on VS and the majority of studies are focused on assessing the role of different treatment modalities. This review emphasizes the need to promote new research projects that encompass the study of molecular mechanisms and other basic sciences. This strategy would lead to the elucidation of novel tumor biomolecular mechanisms and the development of new epigenetic-based targeted therapeutic tools.

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Martinez-Perez, R., Ung, T.H. & Youssef, A.S. The 100 most-cited articles on vestibular schwannoma: historical perspectives, current limitations, and future research directions. Neurosurg Rev 44, 2965–2975 (2021). https://doi.org/10.1007/s10143-021-01487-4

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