Skip to main content
SpringerLink
Log in

Controlled release of doxorubicin from electrospun MWCNTs/PLGA hybrid nanofibers

  • Papers
  • Published:
Chinese Journal of Polymer Science Aims and scope Submit manuscript

Abstract

In this study, multiwalled carbon nanotubes (MWCNTs) were used to encapsulate a model anticancer drug, doxorubicin (Dox). Then, the drug-loaded MWCNTs (Dox/MWCNTs) with an optimized drug encapsulation percentage were mixed with poly(lactide-co-glycolide) (PLGA) polymer solution for subsequent electrospinning to form drug-loaded composite nanofibrous mats. The structure, morphology, and mechanical properties of the formed electrospun Dox/PLGA, MWCNTs/PLGA, and Dox/MWCNTs/PLGA composite nanofibrous mats were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and tensile testing. In vitro viability assay and SEM morphology observation of mouse fibroblast cells cultured onto the MWCNTs/PLGA fibrous scaffolds demonstrate that the developed MWCNTs/PLGA composite nanofibers are cytocompatible. The incorporation of Dox-loaded MWCNTs within the PLGA nanofibers is able to improve the mechanical durability and maintain the three-dimensional structure of the nanofibrous mats. More importantly, our results indicate that this double-container drug delivery system (both PLGA polymer and MWCNTs are drug carriers) is beneficial to avoid the burst release of the drug and able to release the antitumor drug Dox in a sustained manner for 42 days. The developed composite electrospun nanofibrous drug delivery system may be used as therapeutic scaffold materials for post-operative local chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Liu, W., Wen, S., Shen, M. and Shi, X., New J. Chem., 2014, 38: 3917

    Article  CAS  Google Scholar 

  2. Wang, S., Wu, Y., Guo, R., Huang, Y., Wen, S., Shen, M., Wang, J. and Shi, X., Langmuir, 2013, 29(16): 5030

    Article  CAS  Google Scholar 

  3. Peer, D., Karp, J.M., Hong, S., FaroKhzad, O.C., Margalit, R. and Langer, R., Nat. Nanotechnol., 2007, 2(12): 751

    Article  CAS  Google Scholar 

  4. Goldberg, M., Langer, R. and Jia, X.Q., J. Biomater. Sci. Polym. Ed., 2007, 18(3): 241

    Article  CAS  Google Scholar 

  5. Wen, S., Liu, H., Cai, H., Shen, M. and Shi, X., Adv. Healthcare Mater., 2013, 2: 1267

    Article  CAS  Google Scholar 

  6. Fu, F., Wu, Y., Zhu, J., Wen, S., Shen, M. and Shi, X., ACS Appl. Mater. Interfaces, 2014, 6: 16416

    Article  CAS  Google Scholar 

  7. Wang, Y., Cao, X., Guo, R., Shen, M., Zhang, M., Zhu, M. and Shi, X., Polym. Chem., 2011, 2(8): 1754

    Article  CAS  Google Scholar 

  8. Maciel, D., Figueira, P., Xiao, S., Hu, D., Shi, X., Rodrigues, J., Tomás, H. and Li, Y., Biomacromolecules, 2013, 14(9): 3140

    Article  CAS  Google Scholar 

  9. Abbasi, A., Nasef, M.M., Takeshi, M. and Faridi-Majidi, R., Chinese J. Polym. Sci., 2014, 32(6): 793

    Article  CAS  Google Scholar 

  10. Sill, T.J. and von Recum, H.A., Biomaterials, 2008, 29(13): 1989

    Article  CAS  Google Scholar 

  11. Williams, G.R., Chatterton, N.P., Nazir, T., Yu, D.G., Zhu, L.M. and Branford-White, C.J., Ther. Delivery, 2012, 3(4): 515

    Article  CAS  Google Scholar 

  12. Song, Z.M., Shi, B., Ding, J.X., Zhuang, X.L., Zhang, X.N., Fu, C.F. and Chen, X.S., Chinese J. Polym. Sci., 2015, 33(4): 587

    Article  CAS  Google Scholar 

  13. Yun, J., Im, J.S., Lee, Y.S. and Kim, H.I., Eur. Polym. J., 2011, 47(10): 1893

    Article  CAS  Google Scholar 

  14. Jannesari, M., Varshosaz, J., Morshed, M. and Zamani, M., Int. J. Nanomed., 2011, 6: 993

    CAS  Google Scholar 

  15. Zong, X., Li, S., Chen, E., Garlick, B., Kim, K.S., Fang, D., Chiu, J., Zimmerman, T., Brathwaite, C., Hsiao, B.S. and Chu, B., Ann. Surg., 2004, 240(5): 910

    Article  Google Scholar 

  16. Li, W.J., Laurencin, C.T., Caterson, E.J., Tuan, R.S. and Ko, F.K., J. Biomed. Mater. Res. Part A, 2002, 60(4): 613

    Article  CAS  Google Scholar 

  17. Greiner, A. and Wendorff, J.H., Angew. Chem. Int. Ed., 2007, 46(30): 5670

    Article  CAS  Google Scholar 

  18. Guo, G., Fu, S.Z., Zhou, L.X., Liang, H., Fan, M., Luo, F., Qian, Z.Y. and Wei, Y.Q., Nanoscale, 2011, 3(9): 3825

    Article  CAS  Google Scholar 

  19. Zheng, F.Y., Wang, S.G., Shen, M.W., Zhu, M.F. and Shi, X.Y., Polym. Chem., 2013, 4(4): 933

    Article  CAS  Google Scholar 

  20. Ma, G.P., Liu, Y., Peng, C., Fang, D.W., He, B.J. and Nie, J., Carbohydr. Polym., 2011, 86(2): 505

    Article  CAS  Google Scholar 

  21. Xu, X.L., Chen, X.S., Wang, Z.F. and Jing, X.B., Eur. J. Pharm. Biopharm., 2009, 72(1): 18

    Article  CAS  Google Scholar 

  22. Xu, X.L., Chen, X.S., Ma, P.A., Wang, X.R. and Jing, X.B., Eur. J. Pharm. Biopharm., 2008, 70(1): 165

    Article  CAS  Google Scholar 

  23. Xie, J. and Wang, C.H., Pharm. Res., 2006, 23(8): 1817

    Article  CAS  Google Scholar 

  24. Chen, P., Wu, Q.S., Ding, Y.P. and Zhu, Z.C., Nano, 2011, 6(4): 325

    Article  CAS  Google Scholar 

  25. Ranganath, S.H., Fu, Y.L., Arifin, D.Y., Kee, I., Zheng, L., Lee, H.S., Chow, P.K.H. and Wang, C.H., Biomaterials, 2010, 31(19): 5199

    Article  CAS  Google Scholar 

  26. Liu, S., Zhou, G.Y., Liu, D.X., Xie, Z.G., Huang, Y.B., Wang, X., Wu, W.B. and Jing, X.B., J. Mater. Chem. B, 2013, 1(1): 101

    Article  CAS  Google Scholar 

  27. Qi, R., Guo, R., Shen, M., Cao, X., Zhang, L., Xu, J., Yu, J. and Shi, X., J. Mater. Chem., 2010, 20(47): 10622

    Article  CAS  Google Scholar 

  28. Wang, S., Zheng, F., Huang, Y., Fang, Y., Shen, M., Zhu, M. and Shi, X., ACS Appl. Mater. Interfaces, 2012, 4(11): 6393

    Article  CAS  Google Scholar 

  29. Zhao, Y.L., Wang, S.G., Guo, Q.S., Shen, M.W. and Shi, X.Y., J. Appl. Polym. Sci., 2013, 127(6): 4825

    Article  CAS  Google Scholar 

  30. Qi, R., Cao, X., Shen, M., Guo, R., Yu, J. and Shi, X., J. Biomater. Sci. Polym. Ed., 2012, 23: 299

    Article  CAS  Google Scholar 

  31. Mohan, P. and Rapoport, N., Mol. Pharmaceutics, 2010, 7(6): 1959

    Article  CAS  Google Scholar 

  32. Kibria, G., Hatakeyama, H., Ohga, N., Hida, K. and Harashima, H., Biomaterials, 2013, 34(22): 5617

    Article  CAS  Google Scholar 

  33. Zhang, Y., Xiao, C., Li, M., Chen, J., Ding, J., He, C., Zhuang, X. and Chen, X., Macromol. Biosci., 2013, 13(5): 584

    Article  CAS  Google Scholar 

  34. Awadallah-F, A. and Mostafa, T.B., Chinese J. Polym. Sci., 2015, 33(3): 376

    Article  CAS  Google Scholar 

  35. Lu, Y.J., Wei, K.C., Ma, C.C.M., Yang, S.Y. and Chen, J.P., Colloids Surf., B, 2012, 89: 1

    Article  CAS  Google Scholar 

  36. Ren, J., Shen, S., Wang, D., Xi, Z., Guo, L., Pang, Z., Qian, Y., Sun, X. and Jiang, X., Biomaterials, 2012, 33(11): 3324

    Article  CAS  Google Scholar 

  37. Meng, L., Zhang, X., Lu, Q., Fei, Z. and Dyson, P.J., Biomaterials, 2012, 33(6): 1689

    Article  CAS  Google Scholar 

  38. Rodriguez-Galvan, A., Nano, 2016, 11(4): 11

    Article  Google Scholar 

  39. Liao, H., Qi, R., Shen, M., Cao, X., Guo, R., Zhang, Y. and Shi, X., Colloids Surf., B, 2011, 84(2): 528

    Article  CAS  Google Scholar 

  40. Liu, F., Guo, R., Shen, M., Cao, X., Mo, X., Wang, S.H. and Shi, X., Soft Mater., 2010, 8(3): 239

    Article  CAS  Google Scholar 

  41. Liu, F., Guo, R., Shen, M., Wang, S.H. and Shi, X., Macromol. Mater. Eng., 2009, 294(10): 666

    Article  CAS  Google Scholar 

  42. Feng, T.S., Tian, H.Y., Xu, C.N., Lin, L., Lam, M.H.W., Liang, H.J. and Chen, X.S., Chinese J. Polym. Sci., 2015, 33(7): 947

    Article  CAS  Google Scholar 

  43. Xu, J.Z., Xie, Y., Zhang, H.B., Ye, Z.O.Y. and Zhang, W.J., Colloids Surf., B, 2014, 123: 907

    Article  CAS  Google Scholar 

  44. Wang, S.D. and Zhang, Y.Z., Fibers Polym., 2012, 13(6): 754

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China

    Rui-ling Qi, Jian-yong Yu & Xiang-yang Shi  (史向阳)

  2. Department of Textile Engineering, Henan Institute of Engineering, Zhengzhou, 450007, China

    Rui-ling Qi

  3. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China

    Xue-jiao Tian, Rui Guo  (郭睿), Yu Luo, Ming-wu Shen & Xiang-yang Shi  (史向阳)

Authors
  1. Rui-ling Qi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xue-jiao Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rui Guo  (郭睿)
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ming-wu Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jian-yong Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Xiang-yang Shi  (史向阳)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Rui Guo  (郭睿) or Xiang-yang Shi  (史向阳).

Additional information

This work was financially supported by the “111 Project” (No. B07024), the Fundamental Research Funds for the Central Universities (for R. Guo, M. Shen and X. Shi), and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning. R. Qi thanks the Program for Innovative Research Team (in Science and Technology) in University of Henan Province (No. 13IRTSTHN024).

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Qi, Rl., Tian, Xj., Guo, R. et al. Controlled release of doxorubicin from electrospun MWCNTs/PLGA hybrid nanofibers. Chin J Polym Sci 34, 1047–1059 (2016). https://doi.org/10.1007/s10118-016-1827-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10118-016-1827-z

Keywords

Search

Navigation