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Diabetic distal symmetric polyneuropathy: Effect of low-intensity laser therapy

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Abstract

Low-intensity laser therapy (LILT) has been considered as a treatment modality in diabetic distal symmetric polyneuropathy (DSP). The aim of this study is to determine the effectiveness of LILT on DSP. We examined 107 subjects with type 2 diabetes for detection of DSP using the Michigan Neuropathy Screening Instrument (MNSI). Seventeen subjects were eligible to be enrolled in the study. Nerve conduction studies (NCS) were performed in all eligible subjects as an objective method to confirm neuropathy. The participants received LILT three times a week for ten sessions. NCSs were reevaluated after completion of the treatment. The absolute changes in NCS parameters were considered to establish the effectiveness of the treatment. Baseline demographics were similar in all participants. The mean differences of NCV parameters were considered for comparison. At the end of the study, the subjects showed a significant increase in neural potential amplitudes (p < 0.05). This study clearly demonstrated a significant positive effect of LILT on improvement of nerve conduction velocity on diabetic distal symmetric polyneuropathy (DSP). This finding supports the therapeutic potential of LILT in DSP.

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References

  1. Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, Wilson DM, O’Brien PC, Melton LJr, Service FJ (1993) The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology 43(4):817–824

    PubMed  CAS  Google Scholar 

  2. Llewelyn JG, Tomlinson DR, Thomas PK (2005) Diabetic neuropathies. In: Dyck PJ, Thomas PK (eds) Peripheral neuropathy, 4th edn. Elsevier, Philadelphia, pp 1951–1992

    Google Scholar 

  3. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D (2005) Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 28(4):956–962

    Article  PubMed  Google Scholar 

  4. Davies M, Brophy S, Williams R, Taylor A (2006) The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 29(7):1518–1522. doi:10.2337/dc05-2228

    Article  PubMed  Google Scholar 

  5. Pfeifer MA, Ross DR, Schrage JP, Gelber DA, Schumer MP, Crain GM, Markwell SJ, Jung S (1993) A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy. Diabetes Care 16(8):1103–1115

    Article  PubMed  CAS  Google Scholar 

  6. Carrington A, Shaw JE, Van Schie CH, Abbott CA, Vileikyte L, Boulton AJ (2002) Can motor nerve conduction velocity predict foot problems in diabetic subjects over a 6-year outcome period? Diabetes Care 25(11):2010–2015

    Article  PubMed  Google Scholar 

  7. American Diabetes Association (1995) Standardized measures in diabetic neuropathy (Consensus Statement). Diabetes care 18(suppl 1):59–81

    Google Scholar 

  8. Diabetic polyneuropathy in controlled clinical trials: Consensus Report of the Peripheral Nerve Society (1995). Ann Neurol 38 (3):478–482. doi:10.1002/ana.410380323

  9. The Capsaicin Study Group (1991) Treatment of painful diabetic neuropathy with topical capsaicin: a multicenter, double-blind, vehicle-controlled study. Arch Intern Med 151:2225–2229

    Article  Google Scholar 

  10. Zinman LH, Ngo M, Ng ET, Nwe KT, Gogov S, Bril V (2004) Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes Care 27(4):921–924

    Article  PubMed  Google Scholar 

  11. Michigan Diabetes Research and Training Center (2011) Survey Instrument. http://www.med.umich.edu/mdrtc/profs/survey.html Accessed 29 April 2011

  12. Asad A, Hameed MA, Khan UA, Butt MU, Ahmed N, Nadeem A (2009) Comparison of nerve conduction studies with diabetic neuropathy symptom score and diabetic neuropathy examination score in type-2 diabetics for detection of sensorimotor polyneuropathy. J Pak Med Assoc 59(9):594–598

    PubMed  Google Scholar 

  13. Vinik AI, Mitchell BD, Leichter SB, Wagner AL, O’Brian JT, Georges LP (1995) Epidemiology of the Complications of Diabetes. In: Leslie RDGRD (ed) Diabetes: Clinical Science in Practice. Cambridge University Press, Cambridge, pp 221–287

    Google Scholar 

  14. Holzer SECA, Martens L, Cuerdon T, Crystal P, Zagari M (1998) Costs and duration of care for lower extremity ulcers in patients with diabetes. Clin Ther 20:169–181

    Article  PubMed  CAS  Google Scholar 

  15. Slyke M (2000) Painful peripheral diabetic neuropathy: therapeutic approaches. Consult Pharm 15:544–555

    Google Scholar 

  16. Kannan V (2000) review Molecular mechanisms of diabetic neuropathy. Int J Diab Dev Countries 20:101–103

    Google Scholar 

  17. Schroder S, Liepert J, Remppis A, Greten JH (2007) Acupuncture treatment improves nerve conduction in peripheral neuropathy. Eur J Neurol 14(3):276–281. doi:10.1111/j.1468-1331.2006.01632.x

    PubMed  CAS  Google Scholar 

  18. Wang G. Low Level Laser Therapy (LLLT): Technology Assessment (2004) Office of the Medical Director, Department of Labor and Industries. http://www.lni.wa.gov/claimsins/files/omd/lllttechassessmay032004.pdf. Accessed 29 April 2011

  19. Hopkins JT, McLoda TA, Seegmiller JG, David Baxter G (2004) Low-level laser therapy facilitates superficial wound healing in humans: a triple-blind, sham-controlled study. J Athl Train 39(3):223–229

    PubMed  Google Scholar 

  20. Oron A, Oron U, Streeter J, de Taboada L, Alexandrovich A, Trembovler V, Shohami E (2007) Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. J Neurotrauma 24(4):651–656. doi:10.1089/neu.2006.0198

    Article  PubMed  Google Scholar 

  21. Huang YY, Chen AC, Carroll JD, Hamblin MR (2009) Biphasic dose response in low-level light therapy. Dose-Response 7(4):358–383. doi:10.2203/dose-response.09-027.Hamblin

    Article  PubMed  Google Scholar 

  22. Perić Z, Cvetković B (2006) Electrophysiological evaluation of low-intensity laser therapy in patients with diabetic polyneuropathy. FACTA UNIVERSITATIS Series: Medicine and Biology 13(1):11–14

    Google Scholar 

  23. Hawkins D, Houreld N, Abrahamse H (2005) Low-level laser therapy (LLLT) as an effective therapeutic modality for delayed wound healing. Ann N Y Acad Sci 1056:486–493. doi:10.1196/annals.1352.040

    Article  PubMed  CAS  Google Scholar 

  24. Kreisler MB, Haj HA, Noroozi N, Willershausen B (2004) Efficacy of low-level laser therapy in reducing postoperative pain after endodontic surgery—a randomized double blind clinical study. Int J Oral Maxillofac Surg 33(1):38–41

    Article  PubMed  CAS  Google Scholar 

  25. Gur A, Karakoc M, Cevik R, Nas K, Sarac AJ (2003) Efficacy of low-power laser therapy and exercise on pain and functions in chronic low back pain. Lasers Surg Med 32(3):233–238. doi:10.1002/lsm.10134

    Article  PubMed  Google Scholar 

  26. Enwemeka CSPJ, Dowdy DS, Harkness EE, Sanford LE, Woodruff LD (2004) The efficacy of low-power lasers in tissue repair and pain control: a meta-analysis study. Photomed Laser Surg 22(4):323–329

    Article  PubMed  Google Scholar 

  27. Simunovic Z (1996) Low-level laser therapy with trigger points technique: a clinical study on 243 patients. J Clin Laser Med Surg 14(4):163–167

    PubMed  CAS  Google Scholar 

  28. Morshedi H (2009) Low-level laser therapy (LLLT) for chronic low back pain (LBP). Eur J Sci Res 29(1):76–81

    Google Scholar 

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Authors and Affiliations

  1. Endocrine Research Center (Firouzgar), Institute of Endocrinology and Metabolism (Hemmat Campus), Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Ebrahim Khamseh, Nooshafarin Kazemikho, Rokhsareh Aghili & Mojtaba Malek

  2. Department of Medical Genetisc, Tehran University of Medical Sciences, Tehran, Iran

    Nooshafarin Kazemikho

  3. Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nooshafarin Kazemikho, Fataneh Hashem Dabaghian & Ashrafeddin Goushegir

  4. Physical and Rehabilitation Medicine Department, Research Center for Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran

    Bijan Forough

  5. Department of Laser, Milad Hospital, Tehran, Iran

    Marjan Lajevardi

Authors
  1. Mohammad Ebrahim Khamseh
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  2. Nooshafarin Kazemikho
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  3. Rokhsareh Aghili
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  4. Bijan Forough
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  5. Marjan Lajevardi
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  6. Fataneh Hashem Dabaghian
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  7. Ashrafeddin Goushegir
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  8. Mojtaba Malek
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Correspondence to Nooshafarin Kazemikho.

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Khamseh, M.E., Kazemikho, N., Aghili, R. et al. Diabetic distal symmetric polyneuropathy: Effect of low-intensity laser therapy. Lasers Med Sci 26, 831–835 (2011). https://doi.org/10.1007/s10103-011-0977-z

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  • DOI: https://doi.org/10.1007/s10103-011-0977-z

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