Abstract
This study was conducted to evaluate the epidemiology and clinical features of bloodstream infections caused by extended-spectrum β-lactamase-producing E. coli (ESBL-EC) in community-onset bacteremia. Of 929 episodes of community-onset E. coli bacteremia, 4.1% (38/929) had bacteremia with ESBL producers. Of these, 63.2% (24/38) were further classified as healthcare-associated infections. Although most patients had risk factors for infection due to ESBL producers, three patients with urinary tract infection, four patients with cholangitis, and one patient with a liver abscess had no identified predisposing risk factors. The 30-day mortality was 21.1% (8/38). ESBL-EC is a significant cause of bloodstream infection, even in patients with community-onset infection.
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References
Bush K (2001) New β-lactamases in gram-negative bacteria: diversity and impact on the selection of antimicrobial therapy. Clin Infect Dis 32:1085–1089
Paterson DL, Bonomo RA (2005) Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev 18:657–686
Rodriguez-Bano J, Navarro MD, Romero L et al (2006) Bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge. Clin Infect Dis 43:1407–1414
Rodriguez-Bano J, Navarro MD, Romero L et al (2004) Epidemiology and clinical features of infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in nonhospitalized patients. J Clin Microbiol 42:1089–1094
Colodner R, Rock W, Chazan B et al (2004) Risk factors for the development of extended-spectrum beta-lactamase-producing bacteria in nonhospitalized patients. Eur J Clin Microbiol Infect Dis 23:163–167
Kang CI, Kim SH, Park WB et al (2004) Bloodstream infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for mortality and treatment outcome, with special emphasis on antimicrobial therapy. Antimicrob Agents Chemother 48:4574–4581
Friedman ND, Kaye KS, Stout JE et al (2002) Health care-associated bloodstream infections in adults: a reason to change the accepted definitions of community-acquired bacteremia. Ann Intern Med 137:791–797
Mirelis B, Navarro F, Miro E, Mesa RJ, Coll P, Prats G (2003) Community transmission of extended-spectrum β-lactamase. Emerg Infect Dis 9:1024–1025
Chambers HF (2001) The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis 8:178–182
Tomasz A (1999) New faces of an old pathogen: emergence and spread of multidrug-resistant Streptococcus pneumoniae. Am J Med 107:55S–62S
Pedersen G, Schonheyder HC, Steffensen FH, Sorensen HT (1999) Risk of resistance related to antibiotic use before admission in patients with community-acquired bacteraemia. J Antimicrob Chemother 43:119–126
Paterson DL, Ko WC, Von Gottberg A et al (2001) Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory. J Clin Microbiol 39:2206–2212
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C.I. Kang and H.S. Cheong contributed equally to the study.
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Kang, CI., Cheong, H.S., Chung, D.R. et al. Clinical features and outcome of community-onset bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli . Eur J Clin Microbiol Infect Dis 27, 85–88 (2008). https://doi.org/10.1007/s10096-007-0401-6
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DOI: https://doi.org/10.1007/s10096-007-0401-6