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Freezing of gait: overview on etiology, treatment, and future directions

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Abstract

Background

Freezing of gait (FOG) is a disabling motor symptom occurring mainly in the advanced stage of Parkinson’s disease (PD).

Methods

This review outlines the clinical manifestation of FOG and its relationship with levodopa treatment, the differential diagnosis with respect to other neurodegenerative and secondary forms and the available treatment.

Results

We report the proposed models explaining the FOG phenomenon and summarize the available knowledge on FOG etiology’s potential genetic contribution. A complete understanding of the mechanisms underlying FOG in PD is essential to find the best therapy. Different treatment options exist but are still not entirely successful, and often a combination of approaches is needed.

Conclusions

Further studies focusing on the potential genetic role in FOG may increase the knowledge on the FOG etiology and pathophysiology, allowing further individualized treatment strategies for this very disabling phenomenon.

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Authors and Affiliations

  1. Center for Mind/Brain Sciences, University of Trento, Corso Bettini, 31, 38068, Rovereto, TN, Italy

    Marika Falla

  2. Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy

    Marika Falla

  3. Department of Neuroscience, Brotzu Hospital, Cagliari, Italy

    Giovanni Cossu

  4. Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Di Milano, Milano, Italy

    Alessio Di Fonzo

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  3. Alessio Di Fonzo
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MF and ADF contributed to the conception of the review. MF, GC, and ADF wrote the first draft of the manuscript, contributed to manuscript revision, read, and approved the submitted version.

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Falla, M., Cossu, G. & Di Fonzo, A. Freezing of gait: overview on etiology, treatment, and future directions. Neurol Sci 43, 1627–1639 (2022). https://doi.org/10.1007/s10072-021-05796-w

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