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Association between tumor necrosis factor alpha and lymphotoxin alpha gene polymorphisms and migraine occurrence among Jordanians

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Abstract

Inflammatory reactions in the body have been shown to contribute to migraine development. Therefore, genes involved in the inflammatory pathways might play a role in the susceptibility and development of migraine. In this study, polymorphisms in tumor necrosis factor alpha (TNFα) and lymphotoxin alpha (LTA) genes were tested for association with migraine. A total of 398 participants (198 migraine patients and 200 controls) were recruited in the study. Serum TNF level was measured using a sandwich ELISA kit. Lymphocytes’ and monocytes’ counts were obtained from a differential complete blood count profile. Participants’ DNA was extracted and genotyped for rs1800629 and rs1799724 in TNFα, and rs909253 in LTA. Controls had a significantly higher mean lymphocyte count (P = 0.018), while the mean monocyte count and serum TNFα levels did not differ between the two groups (P > 0.05). With respect to gene polymorphisms, the rs1800629 and rs1799724 variants showed significant association with migraine in all subjects, and in males and females when analyzed separately (P < 0.001). The rs909253 did not show any statistical difference in frequencies among the two groups (P > 0.05). Having the A allele in rs1800629 was associated with a higher risk of migraine in both male (OR, 95%; CI, G/A = 3.79 [1.87-7.69]; A/A = 14.22 [1.67-121.14]; P < 0.01) and female (OR, 95%; G/A = 2.54 [1.47-4.38]; A/A = 2.52 [1.12-5.69]; P < 0.001) subjects. In conclusion, rs1800629 and rs1799724 in TNFα showed significant association with migraine among the Jordanian population.

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Data availability

The data that support the findings of this study are available from the corresponding author (K.A.) upon reasonable request.

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Funding

Deanship of Research at Jordan University of Science and Technology (Project 388/2016).

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Authors and Affiliations

  1. Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan

    Nour Hamad, Samer F. Swedan & Omar F. Khabour

  2. Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan

    Karem H. Alzoubi

  3. Department of Neurosciences, Jordan University of Science and Technology, Irbid, 22110, Jordan

    Khalid El-Salem

Authors
  1. Nour Hamad
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  2. Karem H. Alzoubi
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  3. Samer F. Swedan
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  4. Omar F. Khabour
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Correspondence to Karem H. Alzoubi.

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The authors declare that they have no conflicts of interest.

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The protocol of this study was approved by the Institutional Review Board (IRB) of Jordan University of Science and Technology, Irbid, Jordan.

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Written informed consent were obtained from all study participants.

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Hamad, N., Alzoubi, K.H., Swedan, S.F. et al. Association between tumor necrosis factor alpha and lymphotoxin alpha gene polymorphisms and migraine occurrence among Jordanians. Neurol Sci 42, 3625–3630 (2021). https://doi.org/10.1007/s10072-020-04967-5

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  • DOI: https://doi.org/10.1007/s10072-020-04967-5

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