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Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in NMOSD

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Abstract

Neutrophil to lymphocyte ratio (NLR) was introduced to assess the activity in autoimmune diseases. Neuromyelitis optica spectrum disorder (NMOSD) has been defined as a chronic inflammatory disease with a course of relapse-remission. Therefore, the relationship between NLR and NMOSD was assessed in this article. Data of NMOSD patients was extracted. NLR is calculated as the absolute count of neutrophil divided by the absolute count of lymphocytes. Correlations between NLR and characteristics of NMOSD patients were evaluated. Effect of treatments on NLR was also analyzed. Increased level of NLR was observed in patients with NMOSD compared healthy individuals (p < 0.001); moreover, patients who were experiencing acute attack had a higher level of NLR compared with those who in remission (p < 0.001). NLR was correlated with RDW (r = 0.288, p = 0.021), ΔEDSS (r = 0.301, p = 0.016). NLR may be a helpful marker to assess the disease activity of NMOSD. Meanwhile, NLR may reflect the aggravated degree of neurological disability.

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Ouhai, China

    Jie Lin, Jia Li, Xiang Li & Junhui Xia

  2. Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Binbin Xue

  3. Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Huaqing Xu

  4. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Xiaming Huang

  5. Department of General surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Zhichao Yao

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  1. Jie Lin
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  3. Jia Li
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  4. Huaqing Xu
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  7. Xiang Li
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  8. Junhui Xia
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Correspondence to Xiang Li or Junhui Xia.

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Jie Lin and Binbin Xue have same contributions.

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Lin, J., Xue, B., Li, J. et al. Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in NMOSD. Neurol Sci 38, 1859–1863 (2017). https://doi.org/10.1007/s10072-017-3068-5

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  • DOI: https://doi.org/10.1007/s10072-017-3068-5

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