Abstract
It is not a well-established finding in migraine that female sexual dysfunction (FSD) emerging as a natural course of disease, as a result of accompanying depression/anxiety, or an underlying endocrinological abnormality. Our aim is evaluating the relationship among frequency and severity of migraine, FSD, depression, anxiety, and related hormones in migrainous women. We examined 80 migrainous female and 62 controls cross sectionally. Beck Depression and Anxiety Inventories, Female Sexual Dysfunction Inventory, Migraine Disability Assessment Test, and hormonal analysis were done. Independent risk factors were identified by logistic regression analysis and cut-off values were measured with Receiver Operating Curve. FSD was not related to frequency or severity of migraine. Although depression and anxiety was related to arousal and lubrication, they had limited effect in FSD. There were correlations between prolactin (PRL), desire and lubrication, follicular-stimulating hormone FSH and orgasm, luteinizing hormone (LH), and pain. Also FSH-LH combination and PRL were found as independent factors for FSD. FSH-LH combination and PRL were found as independent factors which had effect on FSD in migraine. Our study is a precursor study about the effect of several hormones on FSD and migraine relationship. Hormonal effect on FSD in migraine will be clearer with future studies.
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References
Clayton AH, Groth J (2013) Etiology of female sexual dysfunction. Womens Health (Lond) 9(2):135–137
Song SH, Jeon H, Kim SW, Paick JS, Son H (2008) The prevalence and risk factors of female sexual dysfunction in young Korean women: an internet-based survey. J Sex Med 5(7):1694–1701
Nappi RE, Terreno E, Tassorelli C, Sances G, Allena M, Guaschino E, Antonaci F, Albani F, Polatti F (2012) Sexual function and distress in women treated for primary headaches in a tertiary university center. J Sex Med 9(3):761–769
Abdollahi M, Toghae M, Raisi F, Saffari E (2015) The prevalence of female sexual dysfunction among migraine patients. Iran J Neurol 14(1):8–11
Farmer M, Yoon H, Goldstein I (2016) Future targets for female sexual dysfunction. J Sex Med 13(8):1147–1165
Worsley R, Santoro N, Miller KK, Parish SJ, Davis SR (2016) Hormones and female sexual dysfunction: beyond estrogens and androgens—findings from the fourth International consultation on sexual medicine. J Sex Med 13(3):283–290
Casey PM, MacLaughlin KL, Faubion SS (2016) Impact of Contraception on Female Sexual Function. J Womens Health (Larchmt)
Alcántara Montero A, Sánchez Carnerero CI (2016) Female sexual dysfunction: drug treatment options. SEMERGEN 42(5):33–37
Kwan KS, Roberts LJ, Swalm DM (2005) Sexual dysfunction and chronic pain: the role of psychological variables and impact on quality of life. Eur J Pain 9(6):643–652
Ghajarzadeh M, Jalilian R, Togha M, Azimi A, Hosseini P, Babaei N (2014) Depression, poor sleep, and sexual dysfunction in migraineurs women. Int J Prev Med 5(9):1113–1118
Lipton RB, Scher AI, Kolodner K, Liberman J, Steiner TJ, Stewart WF (2002) Migraine in the United States: epidemiology and patterns of health care use. Neurology 58(6):885–894
Ifergane G, Ben-Zion IZ, Plakht Y, Regev K, Wirguin I (2008) Not only headache: higher degree of sexual pain symptoms among migraine sufferers. J Headache Pain. 9(2):113–117
Smith R (1998) Impact of migraine on the family. Headache 38(6):423–426
Kennedy SH, Rizvi S (2009) Sexual dysfunction, depression, and the impact of antidepressants. J Clin Psychopharmacol 29(2):157–164
Antonaci F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A (2011) Migraine and psychiatric comorbidity: a review of clinical findings. J Headache Pain 15:115–125
Stewart WF, Lipton RB, Dowson AJ, Sawyer J (2001) Development and testing of the Migraine Disability Assessment (MIDAS) Questionnaire to assess headache-related disability. Neurology 56(6 Suppl 1):S20–S28
Beck Aaron T (1998) Psychometric properties of the Beck depression Inventory: Twenty five years of evaluation. Clin Psychol Rev 8(1):77–100
Leyfer OT, Ruberg JL, Woodruff-Borden J (2006) Examination of the utility of the Beck Anxiety Inventory and its factors as a screener for anxiety disorders. J Anxiety Disord 20(4):444–458
Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D'Agostino R Jr (2000) The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment offemale sexual function. J Sex Marital Ther 26:191–208
Burri A, Spector T (2011) Recent and lifelong sexual dysfunction in a female UK population sample: prevalence and risk factors. J Sex Med 8(9):2420–2430
Eraslan D, Yalınay Dikmen P, Ilgaz Aydınlar E, Incesu C (2014) The relation of sexual function to migraine-related disability, depression and anxiety in patients with migraine. J Headache Pain. 15(1):32
Safarinejad MR (2006) Female sexual dysfunction in a population-based study in Iran: prevalence and associated risk factors. Int J Impot Res 18(4):382–395
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Dogan, V.B., Dagdeviren, H., Dirican, A. et al. Hormonal effect on the relationship between migraine and female sexual dysfunction. Neurol Sci 38, 1651–1655 (2017). https://doi.org/10.1007/s10072-017-3023-5
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DOI: https://doi.org/10.1007/s10072-017-3023-5