Αbstract
R1 and R2 blink reflex latencies were investigated blind in 55 patients with chronic tension-type headache, 55 patients with migraine, and 55 headache-free controls. Standard electrical stimulation of the supraorbital nerve was applied and the response was recorded from the ipsilateral orbicularis oculi muscles. There were no R1 or R2 latency differences between the three groups. During migraine attacks we observed a statistically significant reduction of R2 amplitude and area. The main finding of our study was the elicitation of the late R2” response at different interstimulus intervals in migraine patients compared to the tension-type headache and control groups. This could be considered an indication of habituation mechanism hyperexcitability, although further investigation is needed to confirm these findings and establish the neurophysiologic basis. This study suggests that blink reflex studies can be used routinely as a non-evasive and inexpensive method for the evaluation of headache patients.
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References
Bartsch T, Goadsby MD (2005) Anatomy and physiology of pain referral patterns in primary and cervicogenic headache disorders. Headache Curr 2(2):42–48
Moskowitz MA (1993) Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology 43(6 Suppl 3):S16–S20
Bolay H, Reuter U, Dunn AK et al (2002) Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8(2):136–142
Aktekin B, Yaltkaya K, Ozkaynak S et al (2001) Recovery cycle of the blink reflex and exteroceptive suppression of temporalis muscle activity in migraine and tension-type headache. Headache 41(2):142–149
Weiller C, May A, Limmroth V et al (1995) Brain stem activation in spontaneous human migraine attacks. Nat Med 1(7):658–660
Sandrini G, Proietti Cecchini A, Milanov I et al (2002) Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine. Neurosci Lett 317(3):135–138
Shahani BT, Young RR (1972) Human orbicularis oculi reflexes. Neurology 22(2):149–154
Kimura J, Lyon LW (1972) Orbicularis oculi reflex in the Wallenberg syndrome: alteration of the late reflex by lesions of the spinal tract and nucleus of the trigeminal nerve. J Neurol Neurosurg Psychiatry 35(2):228–233
Kimura J (1973) Disorder of interneurons in Parkinsonism. The orbicularis oculi reflex to paired stimuli. Brain 96(1):87–96
Sand T, Zwart JA (1994) The blink reflex in chronic tension-type headache, migraine, and cervicogenic headache. Cephalalgia 14(6):447–450
Katsarava Z, Giffin N, Diener HC et al (2003) Abnormal habituation of ‘nociceptive’ blink reflex in migraine—evidence for increased excitability of trigeminal nociception. Cephalalgia 23(8):814–819
Headache Classification Committee of the International Headache Society (IHS) (2013) The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 33:629–808
Kropp P, Gerber WD (1995) Contingent negative variation during migraine attack and interval: evidence for normalization of slow cortical potentials during the attack. Cephalalgia 15(2):123–128
Wang W, Timsit-Berthier M, Schoenen J (1996) Intensity dependence of auditory evoked potentials is pronounced in migraine: an indication of cortical potentiation and low serotonergic neurotransmission? Neurology 46(5):1404–1409
Afra J, Cecchini AP, De Pasqua V et al (1998) Visual evoked potentials during long periods of pattern-reversal stimulation in migraine. Brain 121(Pt 2):233–241
Bohotin V, Fumal A, Vandenheede M et al (2002) Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine. Brain 125(Pt 4):912–922
Coppola G, Vandenheede M, Di Clemente L et al (2005) Somatosensory evoked high-frequency oscillations reflecting thalamo-cortical activity are decreased in migraine patients between attacks. Brain 128(Pt 1):98–103
Ferrari MD, Saxena RR (1993) On serotonin and migraine: a clinical and pharmacological review. Cephalagia 13(3):151–165
Di Clemente L, Coppola G, Magis D et al (2007) Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine? Brain 130(Pt 3):765–770
De Marinis M, Pujia A, Natale L et al (2003) Decreased habituation of the R2 component of the blink reflex in migraine patients. Clin Neurophysiol 114(5):889–893
Aaseth K, Grande RB, Lundqvist C et al (2014) Pericranial tenderness in chronic tension-type headache: the Akershus population based study of chronic headache. J Headache Pain 5(15):58
Schoenen J (1993) Exteroceptive suppression of temporalis muscle activity: methodological and physiological aspects. Cephalalgia 13:3–10
Avramidis TG, Podicoglou Anastasopoulos IE et al (1998) Blink reflex in migraine and tension-type headache. Headache 38(9):691–696
Bánk J, Bense E, Király C (1992) The blink reflex in migraine. Cephalalgia 12(5):289–292
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Avramidis, T., Bougea, A., Hadjigeorgiou, G. et al. Blink reflex habituation in migraine and chronic tension-type headache. Neurol Sci 38, 993–998 (2017). https://doi.org/10.1007/s10072-017-2885-x
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DOI: https://doi.org/10.1007/s10072-017-2885-x