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Association between G2385R and R1628P polymorphism of LRRK2 gene and sporadic Parkinson’s disease in a Han-Chinese population in south-eastern China

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Abstract

The G2385R and R1628P polymorphisms of the leucine-rich repeat kinase 2 (LRRK2) gene have been reported to be associated with Parkinson’s disease (PD), but no data are available on Han-Chinese population of south-eastern China. This study aimed to investigate whether G2385R and R1628P variants are associated with sporadic PD in this population. Total 1,060 subjects were enrolled; including 550 unrelated healthy controls and 510 patients with sporadic PD. Genotyping of polymorphisms was performed by PCR–restriction fragment length polymorphism analysis. All variant samples were sequenced for further confirmation. The results showed that the A allele of the G2385R variant was significantly enriched in sporadic PD patient group (4.8 %) when compared with control group [1.1 %; odds ratio (OR) 4.58, 95 % confidence interval (CI) 2.42–8.65, P < 0.01]. However, no significant difference in the frequency of the C allele of R1628P polymorphism variant was observed between cases and controls (2.8 vs. 1.7 %, OR 1.67, 95 % CI 0.93–2.99, P = 0.08). In conclusion, this study provides the first evidence that G2385R polymorphism is a risk factor for sporadic PD in Han-Chinese population of south-eastern China.

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Acknowledgments

This work was supported by grants from the Key Program of Scientific Research of Fujian Medical University (No. 2009D064), the Program for Innovative Research Team in Science and Technology at the Fujian Province University (No. FMU-RT002), the Natural Science Foundation of Fujian Province of China (No. 2009J01325) and the Science and Technology Foundation of Quanzhou of Fujian, China (No. 2010Z11).

Conflict of interest

The authors had no conflicts of interest to declare in relation to this article.

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Authors and Affiliations

  1. Department of Neurology and Institute of Neurology, Center of Neuroscience, First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China

    Jiangping Cai, Yi Lin, Wanjin Chen, Qifang Lin, Bin Cai & Ning Wang

  2. Department of Neurology, First Affiliated Hospital of Quanzhou, Fujian Medical University, 248 East Street, Licheng, Quanzhou, 362000, Fujian, China

    Jiangping Cai

  3. Department of Neurology, Zhongshan Hospital, Xiamen University, 201 Hubin South Road, Xiamen, 361004, China

    Weihong Zheng

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  1. Jiangping Cai
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  2. Yi Lin
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  3. Wanjin Chen
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  4. Qifang Lin
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  5. Bin Cai
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  6. Ning Wang
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  7. Weihong Zheng
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Correspondence to Ning Wang.

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Cai, J., Lin, Y., Chen, W. et al. Association between G2385R and R1628P polymorphism of LRRK2 gene and sporadic Parkinson’s disease in a Han-Chinese population in south-eastern China. Neurol Sci 34, 2001–2006 (2013). https://doi.org/10.1007/s10072-013-1436-3

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  • DOI: https://doi.org/10.1007/s10072-013-1436-3

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