Abstract
We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson’s disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1–5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4– 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese.
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References
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Acknowledgment
We thank the National Medical Research and Biomedical Research Council, Singhealth and Duke-NUS Graduate Medical School for their support. These funding agencies did not influence the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
Conflict of interest statement
The authors have no competing interests to declare.
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Tan, E.K., Tan, L.C., Lim, H.Q. et al. LRRK2 R1628P increases risk of Parkinson’s disease: replication evidence. Hum Genet 124, 287–288 (2008). https://doi.org/10.1007/s00439-008-0544-2
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DOI: https://doi.org/10.1007/s00439-008-0544-2