Abstract
This study was conducted to investigate whether albumin-adjusted ischemia-modified albumin index (IMA index) is more sensitive and accurate than ischemia-modified albumin (IMA) as early detection marker of ischemic stroke, and to compare IMA and IMA index in progression and non-progression of ischemic stroke. This case–control study was done at an emergency medical center of a university hospital. 52 patients with neurological symptoms were enrolled (28 Ischemic Stroke Group and 24 Non-Stroke Group). In the ROC analysis of IMA index to diagnose stroke, area under the curve (AUC) was 0.990 (cutoff value 91.4; 95% CI: 0.970–1.000; sensitivity: 95.8%; specificity: 96.4%). The AUC for IMA value was 0.928 (cutoff value 98 U/ml; 95% CI: 0.857–0.999; sensitivity: 87.5%; specificity: 89.3%). The difference between progression (n = 12) and non-progression group (n = 16) in IMA and IMA index were statistically insignificant (p > 0.01). IMA index was more sensitive than conventional IMA value as diagnostic biomarker of stroke, however, arguable as a predictive biomarker for progression of ischemic stroke.
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The authors thank Prof. Woon Ki Paik for his critical review of the manuscript.
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An erratum to this article can be found at http://dx.doi.org/10.1007/s10072-011-0495-6
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Ahn, J.H., Choi, S.C., Lee, W.G. et al. The usefulness of albumin-adjusted ischemia-modified albumin index as early detecting marker for ischemic stroke. Neurol Sci 32, 133–138 (2011). https://doi.org/10.1007/s10072-010-0457-4
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DOI: https://doi.org/10.1007/s10072-010-0457-4