Abstract.
We examined the potential sex-related differences in levodopa pharmacokinetics and their relation with the presence of dyskinesias in a group of 115 patients (67 men, 49 women) with Parkinson’s disease. The patients were given a standard oral dose of levodopa plus benserazide (100/25 mg). The area under the levodopa plasma concentration time curve, corrected for the levodopa test dose (in mg/kg body weight), (AUCw) was significantly higher in women than in men, with a reduced oral clearance. No difference in the proportion of men and women experiencing dyskinesias was observed.
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Martinelli, P., Contin, M., Scaglione, C. et al. Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?. Neurol Sci 24, 192–193 (2003). https://doi.org/10.1007/s10072-003-0125-z
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DOI: https://doi.org/10.1007/s10072-003-0125-z