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A review of applications of metabolomics in osteoarthritis

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Abstract

Osteoarthritis (OA) represents the most prevalent and disabling arthritis worldwide due to its heterogeneous and progressive articular degradation. However, effective and timely diagnosis and fundamental treatment for this disorder are lacking. Metabolomics, a growing field in life science research in recent years, has the potential to detect many metabolites and thus explains the underlying pathophysiological processes. Hence, new specific metabolic markers and related metabolic pathways can be identified for OA. In this review, we aimed to provide an overview of studies related to the metabolomics of OA in animal models and humans to describe the metabolic changes and related pathways for OA. The present metabolomics studies reveal that the pathogenesis of OA may be significantly related to perturbations of amino acid metabolism. These altered amino acids (e.g., branched-chain amino acids, arginine, and alanine), as well as phospholipids, were identified as potential biomarkers to distinguish patients with OA from healthy individuals.

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Abbreviations

ACLT:

anterior cruciate ligament transaction

ARG:

arginase

ATP:

adenosine triphosphate

BCAA:

branched-chain amino acids

GC–MS:

gas chromatography–mass spectrometry

LC–MS:

liquid chromatography–mass spectrometry

LysoPC:

lysophosphatidylcholine

LPA:

lysophosphatidic acid

MD:

meniscal destabilization

mTOR:

mammalian target of rapamycin

NMR:

nuclear magnetic resonance

NO:

nitric oxide

NOS:

NO synthase

OA:

osteoarthritis

OAT:

ornithine aminotransferase

PC:

phosphatidylcholine

PLA2:

phospholipase A2

SF:

synovial fluid

TCA:

tricarboxylic acid

UPLC-MS:

ultra-performance liquid chromatography-tandem mass spectrometry

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Funding

This work was supported by the National Natural Science Foundation of China (81871848).

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Authors and Affiliations

  1. Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People’s Republic of China

    Jie-Ting Li, Ni Zeng, Zhi-Peng Yan & Tao Liao

  2. School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing, 100084, People’s Republic of China

    Guo-Xin Ni

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  1. Jie-Ting Li
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  2. Ni Zeng
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  3. Zhi-Peng Yan
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  4. Tao Liao
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  5. Guo-Xin Ni
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Contributions

All authors discuss the concept of the manuscript. JTL wrote the manuscript. GXN conceived the study; ZN, ZPY, and TL prepared some materials. All authors approved the final version of the manuscript.

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Correspondence to Guo-Xin Ni.

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Li, JT., Zeng, N., Yan, ZP. et al. A review of applications of metabolomics in osteoarthritis. Clin Rheumatol 40, 2569–2579 (2021). https://doi.org/10.1007/s10067-020-05511-8

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