Skip to main content
SpringerLink
Log in

MISS questionnaire in French version: a good tool for children and parents to assess methotrexate intolerance

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

The aim of this study was to assess the relevance for children and parents to use the French-validated version of the methotrexate intolerance severity score (MISS), a measure of methotrexate intolerance for children suffering from juvenile idiopathic arthritis. The French-version MISS was developed following the “Guidelines for the process of cross-cultural adaptation of self-report measures.” The new version was tested in families of children with juvenile idiopathic arthritis who completed the questionnaire twice at a 2-week interval. Item correlations, Cronbach’s alpha, and kappa coefficients were computed to evaluate acceptability, internal consistency, and reproducibility. A culturally acceptable version to French was obtained. A total of 71 individuals were included from May 2015 to November 2015. The results show very good acceptability: good response rate (80%), few missing data (<1%) and good understanding of parents and children. The inter-item, dimension-item, and inter-dimension correlations were satisfactory (except for “vomiting” items–other items correlation). Cronbach’s alpha coefficient was well higher than the usually recommended value of 0.6. The results of validity of internal and external consistencies were satisfactory. We also found good agreement between the test-retest for every family. The empirical discriminative cut-off point of 3 showed a sensitivity of 86% and a specificity of 83%. The MISS questionnaire is quick to complete, easy to use. It can be completed by children or their parents with no significant difference. This validated French-version MISS can help study prevalence and risk factors of methotrexate intolerance, better detect this intolerance, and provide better support for patients on long-term treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Murray KJ, Lovell DJ (2002) Advanced therapy for juvenile arthritis. Best Pract Res Clin Rheumatol 16:361–378

    Article  CAS  PubMed  Google Scholar 

  2. Beukelman T, Ringold S, Davis TE et al (2012) Disease-modifying antirheumatic drug use in the treatment of juvenile idiopathic arthritis: a cross-sectional analysis of the CARRA Registry. J Rheumatol 39:1867–1874. doi:10.3899/jrheum.120110

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ortiz-Alvarez O, Morishita K, Avery G et al (2004) Guidelines for blood test monitoring of methotrexate toxicity in juvenile idiopathic arthritis. J Rheumatol 31:2501–2506

    CAS  PubMed  Google Scholar 

  4. Niehues T, Horneff G, Michels H et al (2005) Evidence-based use of methotrexate in children with rheumatic diseases: a consensus statement of the Working Groups Pediatric Rheumatology Germany (AGKJR) and Pediatric Rheumatology Austria. Rheumatol Int 25:169–178. doi:10.1007/s00296-004-0537-y

    Article  CAS  PubMed  Google Scholar 

  5. Brunner HIM, Johnson ALB, Barron AC et al (2005) Gastrointestinal symptoms and their association with health-related quality of life of children with juvenile rheumatoid arthritis: validation of a gastrointestinal symptom questionnaire. J Clin Rheumatol 11:194–204

    Article  PubMed  Google Scholar 

  6. van der Meer A, Wulffraat NM, Prakken BJ et al (2007) Psychological side effects of MTX treatment in juvenile idiopathic arthritis: a pilot study. Clin Exp Rheumatol 25:480–485

    PubMed  Google Scholar 

  7. Mulligan K, Kassoumeri L, Etheridge A et al (2013) Mothers’ reports of the difficulties that their children experience in taking methotrexate for juvenile idiopathic arthritis and how these impact on quality of life. Pediatr Rheumatol Online J 11:23. doi:10.1186/1546-0096-11-23

    Article  PubMed  PubMed Central  Google Scholar 

  8. Mulligan K, Wedderburn LR, Newman S (2015) The experience of taking methotrexate for juvenile idiopathic arthritis: results of a cross-sectional survey with children and young people. Pediatr Rheumatol Online J. doi:10.1186/s12969-015-0052-6

    PubMed  PubMed Central  Google Scholar 

  9. Silva ACD, Farias A, Sinicato N et al (2014) Reasons for stopping methotrexate treatment in patients with juvenile idiopathic arthritis. Pediatr Rheumatol 12:1–1. doi:10.1186/1546-0096-12-S1-P 199

    Article  Google Scholar 

  10. Ravelli A, Migliavacca D, Viola S et al (1999) Efficacy of folinic acid in reducing methotrexate toxicity in juvenile idiopathic arthritis. Clin Exp Rheumatol 17:625–627

    CAS  PubMed  Google Scholar 

  11. Shea B, Swinden MV, Ghogomu ET et al (2014) Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. J Rheumatol 41:1049–1060. doi:10.3899/jrheum.130738

    Article  CAS  PubMed  Google Scholar 

  12. Bulatović M, Heijstek MW, Verkaaik M et al (2011) High prevalence of methotrexate intolerance in juvenile idiopathic arthritis: development and validation of a methotrexate intolerance severity score. Arthritis Rheum 63:2007–2013. doi:10.1002/art.30367

    Article  PubMed  Google Scholar 

  13. Ćalasan MB, van den Bosch OF, Creemers MC et al (2013) Prevalence of methotrexate intolerance in rheumatoid arthritis and psoriatic arthritis. Arthritis Res Ther 15:R217. doi:10.1186/ar4413

    Article  PubMed  Google Scholar 

  14. van Dijkhuizen EHP, Wulffraat NM (2014) Early predictors of prognosis in juvenile idiopathic arthritis: a systematic literature review. Ann Rheum Dis. doi:10.1136/annrheumdis-2014-205265

    PubMed  Google Scholar 

  15. van Dijkhuizen EH, Ćalasan MB, Pluijm SM et al (2015) Prediction of methotrexate intolerance in juvenile idiopathic arthritis: a prospective, observational cohort study. Pediatr Rheumatol 13:5. doi:10.1186/s12969-015-0002-3

    Article  Google Scholar 

  16. Beaton DE, Bombardier C, Guillemin F, Ferraz MB (2000) Guidelines for the process of cross-cultural adaptation of self-report measures. Spine 25:3186–3191

    Article  CAS  PubMed  Google Scholar 

  17. Sousa VD, Rojjanasrirat W (2011) Translation, adaptation and validation of instruments or scales for use in cross-cultural health care research: a clear and user-friendly guideline. J Eval Clin Pract 17:268–274. doi:10.1111/j.1365-2753.2010.01434.x

    Article  PubMed  Google Scholar 

  18. Wild D, Grove A, Martin M et al (2005) Principles of good practice for the translation and cultural adaptation process for patient-reported outcomes (PRO) measures: report of the ISPOR Task Force for Translation and Cultural Adaptation. Value Health 8:94–104. doi:10.1111/j.1524-4733.2005.04054.x

    Article  PubMed  Google Scholar 

  19. Petty RE, Southwood TR, Manners P et al (2004) International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31:390–392

    PubMed  Google Scholar 

  20. Terwee CB, Bot SDM, de Boer MR et al (2007) Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol 60:34–42. doi:10.1016/j.jclinepi.2006.03.012

    Article  PubMed  Google Scholar 

  21. Fitzpatrick R, Davey C, Buxton MJ, Jones DR (1998) Evaluating patient-based outcome measures for use in clinical trials. Health Technol Assess Winch Engl 2(i–iv):1–74

    CAS  Google Scholar 

  22. Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174

    Article  CAS  PubMed  Google Scholar 

  23. Fatimah N, Salim B, Nasim A et al (2016) Frequency of methotrexate intolerance in rheumatoid arthritis patients using methotrexate intolerance severity score (MISS questionnaire). Clin Rheumatol 35:1341–1345. doi:10.1007/s10067-016-3243-8

    Article  PubMed  Google Scholar 

  24. Fráňová J, Fingerhutová Š, Kobrová K et al (2016) Methotrexate efficacy, but not its intolerance, is associated with the dose and route of administration. Pediatr Rheumatol Online J 14:36. doi:10.1186/s12969-016-0099-z

    Article  PubMed  PubMed Central  Google Scholar 

  25. Scheuern A, Fischer N, McDonald J et al (2016) Mutations in the MTHFR gene are not associated with methotrexate intolerance in patients with juvenile idiopathic arthritis. Pediatr Rheumatol Online J 14:11. doi:10.1186/s12969-016-0071-y

    Article  PubMed  PubMed Central  Google Scholar 

  26. Singh G, Athreya BH, Fries JF, Goldsmith DP (1994) Measurement of health status in children with juvenile rheumatoid arthritis. Arthritis Rheum 37:1761–1769. doi:10.1002/art.1780371209

    Article  CAS  PubMed  Google Scholar 

  27. Russell KMW, Hudson M, Long A, Phipps S (2006) Assessment of health-related quality of life in children with cancer: consistency and agreement between parent and child reports. Cancer 106:2267–2274. doi:10.1002/cncr.21871

    Article  PubMed  Google Scholar 

  28. Sawyer MG, Carbone JA, Whitham JN et al (2005) The relationship between health-related quality of life, pain, and coping strategies in juvenile arthritis—a one year prospective study. Qual Life Res 14:1585–1598. doi:10.1007/s11136-004-7710-3

    Article  PubMed  Google Scholar 

  29. Robien K (2005) Folate during antifolate chemotherapy: what we know... and do not know. Nutr Clin Pract 20:411–422. doi:10.1177/0115426505020004411

    Article  PubMed  Google Scholar 

  30. Dolgin MJ, Katz ER, McGinty K, Siegel SE (1985) Anticipatory nausea and vomiting in pediatric cancer patients. Pediatrics 75:547–552

    CAS  PubMed  Google Scholar 

  31. Myers MG, Cairns JA, Singer J (1987) The consent form as a possible cause of side effects. Clin Pharmacol Ther 42:250–253

    Article  CAS  PubMed  Google Scholar 

  32. Barsky AJ, Saintfort R, Rogers MP, Borus JF (2002) Nonspecific medication side effects and the nocebo phenomenon. JAMA 287:622–627. doi:10.1001/jama.287.5.622

    Article  PubMed  Google Scholar 

  33. Colloca L, Miller FG (2011) The nocebo effect and its relevance for clinical practice. Psychosom Med 73:598–603. doi:10.1097/PSY.0b013e3182294a50

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors thank all the parents and the patients who took part in this study.

Special thanks to Juliette Berthot, Virginie Ernoult, Jean-Emmanuel Guerlesquin, and John Hargreaves for their role in helping to obtain and validate the French version of the MISS questionnaire.

Author information

Author notes

  1. Aurélie Chausset and Tiphaine Fargeix both contributed equally to this work.

Authors and Affiliations

  1. CHU Clermont-Ferrand Pediatrics, Hôpital Estaing, Clermont-Ferrand, France

    Aurélie Chausset, Tiphaine Fargeix, Stéphane Echaubard & Etienne Merlin

  2. INSERM, CIC1405, Unité CRECHE, Clermont-Ferrand, France

    Aurélie Chausset & Etienne Merlin

  3. CHU Clermont-Ferrand, Biostatistics Unit (DRCI), Villa Annexe IFSI, Clermont-Ferrand, France

    Bruno Pereira

  4. Department of Pediatric Rheumatology, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Claude Bernard University Lyon 1, University of Lyon, Lyon, France

    Agnès Duquesne, Marine Desjonquères & Caroline Freychet

  5. Laboratoire HESPER (Health Service and Performance Research), Claude Bernard University Lyon 1, EA7425, Lyon, France

    Caroline Freychet

  6. Department of Pediatric Rheumatology, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Claude Bernard University Lyon 1, University of Lyon, INSERM U1111, Lyon, France

    Alexandre Belot

Authors
  1. Aurélie Chausset
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tiphaine Fargeix
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bruno Pereira
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Stéphane Echaubard
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Agnès Duquesne
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marine Desjonquères
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Caroline Freychet
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alexandre Belot
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Etienne Merlin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Aurélie Chausset.

Ethics declarations

Disclosures

None.

Sources of funding

None.

Electronic supplementary material

Appendix 1

(DOCX 13 kb)

Appendix 2

(DOCX 15 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chausset, A., Fargeix, T., Pereira, B. et al. MISS questionnaire in French version: a good tool for children and parents to assess methotrexate intolerance. Clin Rheumatol 36, 1281–1288 (2017). https://doi.org/10.1007/s10067-017-3638-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-017-3638-1

Keywords

Search

Navigation