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Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study

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Abstract

The objective of the present longitudinal study was to clarify whether osteophytosis and joint space narrowing predict quality of life (QOL) decline using a longitudinal population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. The present study analyzed 1,525 participants who completed the radiographic examination at baseline and questionnaires regarding QOL at a 3-year follow-up (546 men and 979 women; mean age, 67.0 ± 11.0 years). This study examined the associations of osteophyte area (OPA) and minimum joint space width (mJSW) in the medial compartment of the knee at baseline with pain and physical functional disability measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). OPA and mJSW in the medial compartment of the knee were measured using a knee osteoarthritis (OA) computer-aided diagnosis system. Overall, OPA independently predicted physical functional disability after 3 years of follow-up. When analyzed in men and women separately, OPA, rather than mJSW, was an independent predictor for pain and physical functional disability after 3 years of follow-up in men. OPA, rather than mJSW, also predicted worsening of pain in men during the 3-year follow-up, whereas in women, mJSW, rather than OPA, predicted worsening of pain. In conclusion, the present longitudinal study using a large-scale population from the ROAD study found gender differences in the association of osteophytosis and joint space narrowing with pain and physical functional disability.

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Acknowledgments

The authors wish to thank Dr. Seizo Yamamoto, Hideaki Ishibashi, Yorito Anamizu, and the other members of the Department of Orthopedics at Tokyo Metropolitan Geriatric Medical Center; Mr. Kutsuma and the other members of the Department of Radiology at Tokyo Metropolitan Geriatric Medical Center; Mrs. Tomoko Takijiri and the other members of the Public Office in Hidakagawa Town; and Mrs. Tamako Tsutsumi, Mrs. Kanami Maeda, and the other members of the Public Office in Taiji Town, for their assistance in locating and scheduling participants for examinations.

Funding

This work was supported by Grants-in-Aid for Scientific Research (S19109007, B20390182, C20591737, C20591774), for Young Scientists (A18689031), and for Exploratory Research (19659305) from the Japanese Ministry of Education, Culture, Sports, Science and Technology; grants (H17-Men-eki-009, H18-Choujyu-037, H20-Choujyu-009, H21-Chouju-Wakate-011, and H22-Chouju-Wakate-007) from the Ministry of Health, Labor and Welfare, a Research Aid from the Japanese Orthopaedic Association (JOA-Subsidized Science Project Research 2006–1) and Grant No. 166 from the Japan Orthopaedics and Traumatology Foundation are also acknowledged.

Disclosures

All authors have no conflicts of interest to state.

Author information

Authors and Affiliations

  1. Department of Clinical Motor System Medicine, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan

    Shigeyuki Muraki & Toru Akune

  2. Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan

    Keiji Nagata, Yuyu Ishimoto & Munehito Yoshida

  3. Department of Orthopaedic Surgery, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan

    Fumiaki Tokimura

  4. Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

    Sakae Tanaka & Hiroshi Kawaguchi

  5. National Rehabilitation Center for Persons with Disabilities, Saitama, Japan

    Kozo Nakamura

  6. Department of Joint Disease Research, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

    Hiroyuki Oka & Noriko Yoshimura

Authors
  1. Shigeyuki Muraki
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  2. Toru Akune
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  3. Keiji Nagata
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  4. Yuyu Ishimoto
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Correspondence to Shigeyuki Muraki.

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Muraki, S., Akune, T., Nagata, K. et al. Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study. Clin Rheumatol 34, 1589–1597 (2015). https://doi.org/10.1007/s10067-014-2687-y

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  • DOI: https://doi.org/10.1007/s10067-014-2687-y

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