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Antisynthetase antibody syndrome: case report and review of the literature

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Abstract

Antisynthetase antibody syndrome is a rare autoimmune disease that may present with variable systemic manifestations, mainly polymyositis, interstitial lung disease, skin lesions, and Raynaud’s phenomenon. This diagnosis should always come to mind in patients that present with signs of myositis, dermatomyositis, or polymyositis associated with interstitial lung disease. On the following paper, we report the case of a 52-year-old man who presented with a 2-month history of asymmetric polyarthralgia, myalgia, weight loss of 8 kg, and progressive muscle weakness associated with dyspnea, orthopnea, and dysphonia. Further tests revealed myositis, interstitial pneumonia, and elevation of anti-Jo-1 antibodies. A diagnosis of antisynthetase antibody syndrome was made and the patient showed good response to treatment with corticoids and methotrexate. Finally, we present a short review of the literature.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia

    Laura Uribe

  2. Department of Internal Medicine, Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia

    Diana Maria Ronderos

  3. Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Pontificia Universidad Javeriana–Hospital Universitario San Ignacio–Grupo Javeriano de Investigación en Enfermedades Reumáticas, Bogotá, Colombia

    Maria Claudia Díaz, Juan Martín Gutierrez & Daniel Gerardo Fernandez-Avila

  4. Human Genetics Institute, Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia

    Christina Mallarino

Authors
  1. Laura Uribe
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  2. Diana Maria Ronderos
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  3. Maria Claudia Díaz
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  4. Juan Martín Gutierrez
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  5. Christina Mallarino
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  6. Daniel Gerardo Fernandez-Avila
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Correspondence to Daniel Gerardo Fernandez-Avila.

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Uribe, L., Ronderos, D.M., Díaz, M.C. et al. Antisynthetase antibody syndrome: case report and review of the literature. Clin Rheumatol 32, 715–719 (2013). https://doi.org/10.1007/s10067-013-2207-5

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  • DOI: https://doi.org/10.1007/s10067-013-2207-5

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