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Beneficial effect of treatment with cyclosporin A in a case of refractory antisynthetase syndrome

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Abstract

We report a case of idiopathic inflammatory myopathy accompanied with the presence of anti-Jo1 antibodies and complicated by diffuse parenchymal lung disease (antisynthetase syndrome). Efficacy of different therapeutic agents, including corticosteroids, cyclophosphamide and cyclosporin A, is described. We present beneficial effect of cyclosporin A and corticosteroids regimen, and confirm no benefits of plasmapheresis. An interesting association of the disease onset with toxoplasmosis infection is discussed and difficulties regarding diagnosis of cardiac involvement are addressed. We also review other case reports of this rare disorder of poor prognosis.

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Authors and Affiliations

  1. Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Ul. Debinki 7, 80-294, Gdansk, Poland

    Magdalena Jankowska, Barbara Butto, Alicja Dębska-Ślizień & Bolesław Rutkowski

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  1. Magdalena Jankowska
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  2. Barbara Butto
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  3. Alicja Dębska-Ślizień
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  4. Bolesław Rutkowski
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Correspondence to Magdalena Jankowska.

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Jankowska, M., Butto, B., Dębska-Ślizień, A. et al. Beneficial effect of treatment with cyclosporin A in a case of refractory antisynthetase syndrome. Rheumatol Int 27, 775–780 (2007). https://doi.org/10.1007/s00296-006-0289-y

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  • DOI: https://doi.org/10.1007/s00296-006-0289-y

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