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Etiopathogenesis of Behçet's disease with emphasison the role of immunological aberrations

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Abstract

Behçet's disease (BD) is a chronic multisystemic inflammatory disorder of unknown origin consisting of oral aphthous ulcers, ocular symptoms, skin lesions, and genital ulcerations. It has many features in common with systemic vasculitides and is more prevalent in countries along the ancient Silk route. Immune-mediated mechanisms play a major role in the pathogenesis of the disease, and inflammatory mediators are also involved. BD is not considered to be an autoimmune disorder, and the character of the disease needs to be clarified. Immunological aberrations in BD have been extensively studied by many investigators; genetic factors have been related to disease susceptibility, but their exact role in the development of disease is uncertain. Environmental factors such as infectious agents have also been implicated in the etiology of BD. However, the etiopathogenesis of the disease remains to be elucidated. Factors involved in the immunopathogenesis of BD with emphasis on the role of immunological aberrations are analyzed in this review.

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Authors and Affiliations

  1. Department of Microbiology, Medical School, University of Athens, 17, Agiou Thoma Street, 11527, Athens, Greece

    Violetta D. Kapsimali

  2. First Department of Internal Medicine, University of Athens, Laikon Hospital, Athens, Greece

    Meletios A. Kanakis & George A. Vaiopoulos

  3. Athens Medical Center, Athens, Greece

    Phaedon G. Kaklamanis

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  1. Violetta D. Kapsimali
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  2. Meletios A. Kanakis
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  3. George A. Vaiopoulos
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  4. Phaedon G. Kaklamanis
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Correspondence to Violetta D. Kapsimali.

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Kapsimali, V.D., Kanakis, M.A., Vaiopoulos, G.A. et al. Etiopathogenesis of Behçet's disease with emphasison the role of immunological aberrations. Clin Rheumatol 29, 1211–1216 (2010). https://doi.org/10.1007/s10067-010-1491-6

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  • DOI: https://doi.org/10.1007/s10067-010-1491-6

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