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Association of Major Histocompatibility Complex Class I Chain-Related Gene A and HLA-B Alleles with Behçet's Disease in Turkey

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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

Behçet's disease (BD) is known to be associated with HLA-B*51 in many different ethnic groups. Recently, the major histocompatibility complex class I chain-related gene A (MICA), located near the HLA-B gene, has been proposed as a candidate gene for BD susceptibility in several ethnic groups. To compare the relative contribution of MICA polymorphisms and HLA-B*51 to BD in different ethnic groups, we studied MICA polymorphisms in Turkish BD patients.

Methods

Thirty-three Turkish BD patients and 65 healthy controls were enrolled for analysis of polymorphisms in the extracellular domains of MICA.

Results

The phenotype frequencies of MICA*009 were significantly higher in BD patients (75.8%) than in controls (29.2%) (P = 0.000015). HLA-B*51 was also significantly more frequent in BD patients (81.8%) than in controls (29.2%) (P = 0.0000007). A strong association existed between MICA*009 and HLA-B*51. To assess the confounding effect of MICA*009 on HLA-B*51, we performed a stratification analysis that showed that BD was distinctly associated only with HLA-B*51.

Conclusion

Our results indicate that the major susceptibility gene for BD is HLA-B*51 and that the association between MICA*009 and BD arises from a strong linkage disequilibrium with HLA-B*51. However, we suggest that MICA*009 likely elicits an immune effect secondary to BD. Jpn J Ophthalmol 2007;51:431–436 © Japanese Ophthalmological Society 2007

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Nobuko Mizuki & Iwai Tohnai

  2. Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Akira Meguro & Nobuhisa Mizuki

  3. Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Ahmet Gül

  4. Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Shigeaki Ohno

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  1. Nobuko Mizuki
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  2. Akira Meguro
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  3. Iwai Tohnai
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  4. Ahmet Gül
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  5. Shigeaki Ohno
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  6. Nobuhisa Mizuki
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Correspondence to Nobuhisa Mizuki.

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Mizuki, N., Meguro, A., Tohnai, I. et al. Association of Major Histocompatibility Complex Class I Chain-Related Gene A and HLA-B Alleles with Behçet's Disease in Turkey. Jpn J Ophthalmol 51, 431–436 (2007). https://doi.org/10.1007/s10384-007-0473-y

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  • DOI: https://doi.org/10.1007/s10384-007-0473-y

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